Biostatistics, Epidemiology, and Research Design Core

生物统计学、流行病学和研究设计核心

• 批准号: 10438751
• 负责人: Julie A Stoner
• 金额: $ 65.99万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438751
• 关键词: Address; Adoption; American Indians; Applications Grants; Area; Basic Science; Biometry; Biostatistical Methods; Clinical; Clinical Research; Clinical Sciences; Communities; Community Health; Computerized Medical Record; Consult; Consultations; Data; Data Collection; Data Reporting; Data Set; Data Sources; Databases; Degree program; Development; Diagnostic Procedure; Discipline; Disease; Dissemination and Implementation; Educational workshop; Effectiveness; Ensure; Epidemiologic Methods; Epidemiologic Research Design; Epidemiology; Extramural Activities; Faculty; Funding; Grant; Health; Health Professional; Health system; Infrastructure; Institution; Laboratory Research; Master of Science; Measurement; Medical; Methodology; Methods; Mission; Oklahoma; Patients; Peer Review; Personal Satisfaction; Population; Population Surveillance; Prevention strategy; Process; Productivity; Publications; Qualitative Research; Quality Control; Randomized Controlled Clinical Trials; Recommendation; Registries; Reporting; Reproducibility; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk Factors; Sample Size; Science; Secure; Source; Statistical Methods; Students; Surveys; System; Therapeutic Intervention; Training; Translational Research; Tribes; Work; analytical method; base; clinical care; clinical data warehouse; cohort; community based research; data quality; data repository; data warehouse; design; epidemiology study; health assessment; health organization; implementation design; implementation study; improved; innovation; instrument; intervention program; lectures; member; novel; novel strategies; population health; preclinical study; programs; repository infrastructure; research study; secondary analysis; skills; success; surveillance data; translational study; treatment strategy

Effective clinical and translational research requires rigorous study designs, appropriate application of analytic methods, and careful reporting. The Biostatistics, Epidemiology, and Research Design (BERD) has been instrumental in expanding clinical and translational research of new investigators, community partners, and programs of the OSCTR, supporting over 470 research projects, resulting in 72 peer-reviewed publications and 112 grant applications (78 extramural and 34 intramural applications). The BERD has enhanced research methods training (130 seminars/lectures, supporting 25 MS in Clinical and Translational Science thesis projects), expanded the use of novel analytic methods and research designs (31 publications, 48 seminars, five workshops, and two grant-funded projects), and expanded research infrastructure through the deployment of a survey calling center and enhanced REDCap infrastructure, growing use from 6 projects/year to 207 projects in 2016. The revised mission of the BERD Core is to enable OSCTR investigators and partner institutions to design, perform, and report rigorous, reproducible, and innovative studies that can be applied to improve clinical care and patient well-being in Oklahoma and other IDeA states. To do this, the BERD Core provides consultative expertise in biostatistics, epidemiology, and qualitative research methods (Aim 1); coordinates a new, unique and robust data repository infrastructure and analytic skill set for clinical epidemiologic studies (Aim 2); and develops and applies novel research designs and analytic methods focused on the needs of OSCTR research (Aim 3). BERD Core members collaborate with investigators to address sources of bias, identify sufficient sample sizes, select measurement instruments, perform data quality control, manage and analyze data, and report study results. The BERD Core works with the Professional Development Core to develop workshops on research methods, and with the Administrative Core to produce training videos, templates, and fact sheets for the portal. A new BERD initiative with this renewal, the Clinical Data Warehouse, leverages a unique resource developed at OUHSC to make de-identified electronic medical records available for research to enhance the capacity for clinical epidemiologic and population health research in Oklahoma. The BERD Core helps investigators identify appropriate data sources and variables to address their research questions, then uses the Clinical Data Warehouse validated process to generate a project dataset. Finally, to advance biostatistics and epidemiologic methods, the BERD Core holds monthly seminars to disseminate novel research designs, analysis methods, and research findings. The BERD Core performs methodological research to adapt existing methods or develop new approaches to address research questions, for example, developing new statistical methods to reduce bias and increase estimation efficiency in small populations, such as American Indian tribes. Together, these activities of the BERD Core enable OSCTR investigators to perform rigorous, reproducible, and innovative research to better understand and address health needs in Oklahoma.

有效的临床和转化性研究需要严格的研究设计，适当的分析应用 方法，以及仔细的报道。生物统计学、流行病学和研究设计(BERD) 有助于扩大新研究人员、社区合作伙伴和 支持470多个研究项目，产生了72份同行评议的出版物和 112项赠款申请(78项校外申请和34项内部申请)。BERD加强了研究 方法培训(130个研讨会/讲座，支持25个临床和翻译科学论文 项目)，扩大使用新的分析方法和研究设计(31份出版物，48个研讨会， 五个讲习班和两个赠款资助项目)，并通过部署扩大研究基础设施 调查呼叫中心和增强型RedCap基础设施，使用量从每年6个项目增加到207个 2016年的项目。BERD核心的修订使命是使OSCTR调查人员和合作伙伴能够 设计、执行和报告可应用于以下领域的严谨、可重复性和创新性研究的机构 改善俄克拉荷马州和其他州的临床护理和患者福祉。要做到这一点，BERD核心 提供生物统计学、流行病学和定性研究方法方面的咨询专业知识(目标1)； 为临床协调新的、独特的、强大的数据存储库基础架构和分析技能集 流行病学研究(目标2)；开发和应用新的研究设计和分析方法 关于大规模毁灭性武器研究的需要(目标3)。BERD核心成员与调查人员合作解决 偏差来源，确定足够的样本量，选择测量仪器，执行数据质量控制， 管理和分析数据，并报告研究结果。BERD核心致力于专业发展 核心开发研究方法讲习班，并与行政核心一起制作培训视频， 模板和门户的情况说明书。这次更新带来了一个新的BERD计划，即临床数据仓库， 利用OUHSC开发的独特资源，使未识别的电子病历可用 用于增强俄克拉荷马州临床流行病学和人口健康研究能力的研究。 BERD核心帮助调查人员确定适当的数据源和变量来解决他们的研究 问题，然后使用临床数据仓库验证流程来生成项目数据集。最后，为了 先进的生物统计学和流行病学方法，BERD核心每月举办研讨会，传播 新颖的研究设计、分析方法和研究成果。BERD核心执行方法论 调整现有方法或开发新的方法来解决研究问题的研究，例如， 开发新的统计方法，以减少偏差并提高小群体的估计效率，例如 作为美洲印第安人部落。综合起来，BERD核心的这些活动使OSCTR调查人员能够执行 严谨、可重复和创新的研究，以更好地了解和解决俄克拉荷马州的卫生需求。