Mating behavior in Drosophila as a model for understanding and controlling aberrant dopaminergic responses
果蝇的交配行为作为理解和控制异常多巴胺能反应的模型
基本信息
- 批准号:9982280
- 负责人:
- 金额:$ 53.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:AllelesBehavior ControlBehavioralBiological ModelsCopulationCourtshipDiagnosisDiagnosticDopamineDrosophila genusDrosophila melanogasterDrug AddictionDrug TargetingDrug ToleranceGenesGenetic HeterogeneityGenetic Predisposition to DiseaseGoalsHeritabilityIndividualInterventionMammalsMendelian disorderModelingMolecularMotivationMutationNarcoticsNeuronsPatientsPharmaceutical PreparationsPlant RootsPopulationPredispositionRecording of previous eventsRegulationSignal TransductionSusceptibility GeneSystemWorkaddictionbehavioral studycausal variantcombatdopaminergic neurondrug of abusehedonichigh riskinnovationmalemating behaviormotivated behaviorneural networknew therapeutic targetnovelpreventresponsesexual dimorphismtargeted treatmenttherapy designtrait
项目摘要
Summary:
It is well known that individuals differ in drug tolerance and propensity for addiction, and that both of
these traits are highly heritable, resulting from interactions of many alleles. This multi-genic heritability makes
diagnosing susceptibility and targeted treatment more difficult than for monogenic disorders. Despite the vast
genetic heterogeneity, there are core principles of abuse and addiction that provide possibilities for new
treatments: all drugs of abuse derive their hedonic qualities by upregulating dopamine signaling, and
alterations in dopaminergic circuitry following repeated exposure are the root cause of addiction. It is therefore
likely that many of the relevant genetic susceptibility loci are involved in the regulation of dopamine responses
to drugs and triggering situations. If we refine our ability to precisely manipulate dopaminergic circuitry, we will
be able to design treatments to counter the causes of abuse and addiction that are tailored to the individual,
without necessarily needing to correct the causal alleles. The importance and potential of studying
dopaminergic control systems to combat addiction have long been recognized; I propose a new and promising
approach to rapidly identify the circuit and molecular principles of dopaminergic regulation.
My lab has recently established two new systems for studying dopaminergic control of motivated
behavior. In these systems, two separate populations of dopaminergic neurons provide dynamic motivational
input into two distinct aspects of male mating behavior in Drosophila melanogaster: courtship and copulation.
The small populations of dopaminergic neurons that control these behaviors are embedded within neural
networks that precisely tune the amount of dopamine released so that the level of motivation matches the
relevance of the behavioral goals. We study these behaviors because i) they show clear hallmarks of
dopaminergic regulation of motivation; ii) they are robust, unambiguous, and easily quantified; iii) the
underlying neurons are identifiable and genetically accessible through their expression of sexually dimorphic
genes; and iv) the history of work in Drosophila suggests that the principles we uncover will apply to mammals.
The main goal of this work is to generate new hypotheses and drug targets for interventions that will prevent
the onset and persistence of drug addiction. The characterization of novel regulators of motivational
dopaminergic circuitry will also be of use in identifying people at high-risk for abuse and addiction through their
possession of altered alleles at these loci.
This project is innovative because it combines circuit and molecular approaches in a simple model
system to rapidly identify behaviorally-relevant regulators of dopaminergic activity. I do not believe that any
such approach has been taken before and it therefore promises new discoveries and potential for treatments
and diagnostics.
简介:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael A Crickmore其他文献
Michael A Crickmore的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael A Crickmore', 18)}}的其他基金
Circuit principles of demotivation in the decision to switch behaviors
决定改变行为时动机丧失的电路原理
- 批准号:
10396538 - 财政年份:2019
- 资助金额:
$ 53.1万 - 项目类别:
Circuit principles of demotivation in the decision to switch behaviors
决定改变行为时动机丧失的电路原理
- 批准号:
10612399 - 财政年份:2019
- 资助金额:
$ 53.1万 - 项目类别:
Mating behavior in Drosophila as a model for understanding and controlling aberrant dopaminergic responses
果蝇的交配行为作为理解和控制异常多巴胺能反应的模型
- 批准号:
10221658 - 财政年份:2017
- 资助金额:
$ 53.1万 - 项目类别:
Mating behavior in Drosophila as a model for understanding and controlling aberrant dopaminergic responses
果蝇的交配行为作为理解和控制异常多巴胺能反应的模型
- 批准号:
9376434 - 财政年份:2017
- 资助金额:
$ 53.1万 - 项目类别:
相似海外基金
Development of physical activity promotion and sedentary behavior control strategies in young children
幼儿体力活动促进和久坐行为控制策略的制定
- 批准号:
19K11620 - 财政年份:2019
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Research on Dispersion Behavior Control and Its Application of Nanoparticles Using High Electric Field Technique
高电场技术纳米颗粒分散行为控制及其应用研究
- 批准号:
15K05996 - 财政年份:2015
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of High Efficiency Chemical Mechanical Polishing Method of Hard-to-Process Materials Using Slurry Behavior Control
利用浆料行为控制开发难加工材料的高效化学机械抛光方法
- 批准号:
25420070 - 财政年份:2013
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on the Relationship Between the Formation of Close Friendships and Changes in Behavior :Focusing on Children with Difficulty in Behavior Control
亲密友谊的形成与行为改变的关系研究——以行为控制困难儿童为中心
- 批准号:
25590229 - 财政年份:2013
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Resonant behavior control through ferroelectric polarization and its applications to vibratory MEMS devices with improved functionality
通过铁电极化控制谐振行为及其在具有改进功能的振动 MEMS 器件中的应用
- 批准号:
23360136 - 财政年份:2011
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Prediction-based Behavior Control Mechanism of Agent Organization
基于预测的Agent组织行为控制机制
- 批准号:
22500116 - 财政年份:2010
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Behavior control by resonance ofperiodic behavior and an internal state
通过周期性行为和内部状态的共振来控制行为
- 批准号:
22686040 - 财政年份:2010
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
linguistic structure and behavior control on theory of mind: Does the impulse of young children disturb their reading of other's mind?
心理理论的语言结构和行为控制:幼儿的冲动是否会干扰他们对他人思想的解读?
- 批准号:
18500208 - 财政年份:2006
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Behavior Control of Apelike Robot Based on Multi-Sensor Integration
基于多传感器集成的类猿机器人行为控制
- 批准号:
07455108 - 财政年份:1995
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Researchs for Behavior Control of Insect Pests based on Host-selection of Insects.
基于昆虫寄主选择的害虫行为控制研究。
- 批准号:
61560051 - 财政年份:1986
- 资助金额:
$ 53.1万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)