Influence of prenatal air pollutant and stress exposures on sleep outcomes in urban preschool-aged children

产前空气污染物和压力暴露对城市学龄前儿童睡眠结局的影响

基本信息

批准号：
9982423
负责人：
Sonali Bose
金额：
$ 84.51万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-24 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982423
关键词：
5 year old Accelerometer Accounting Affect African American Age Air Pollutants Air Pollution Behavioral Biological Chemicals Child Childhood Chronic Cognitive Complex Development Dose Environmental Risk Factor Ethnic Origin Etiology Event Exposure to Fetus Foundations Growth and Development function Hair Health High Prevalence Home environment Hydrocortisone Intervention Joints Latino Lead Life Link Longitudinal prospective study Low income Measures Mediating Modeling Modification Mothers Neuraxis Neuronal Plasticity Neurotoxins Nursery Schools Outcome Parents Particulate Matter Phenotype Physical environment Pollution Polysomnography Predisposition Pregnancy Problem behavior Process Prospective Studies Psychological Stress Psychosocial Stress Questionnaires Race Reporting Risk Role Sleep Sleep Architecture Sleep Disorders Sleep disturbances Social Environment Socioeconomic Status Standardization Statistical Methods Stress Temperament Toxicant exposure Trauma adequate sleep aged antepartum depression base biological adaptation to stress cohort critical period depressive symptoms diaries early childhood ethnic difference ethnic minority population fetal fine particles health disparity in utero indexing infancy infant temperament insight intergenerational low socioeconomic status maternal stress negative affect neurodevelopment neurodevelopmental effect physical conditioning pollutant post-traumatic symptoms postnatal prenatal prenatal exposure prenatal influence prenatal stress prevent psychobiologic psychologic racial and ethnic relating to nervous system sex sleep behavior sleep onset sleep regulation social stressor trait urban dwelling

项目摘要

Project Summary/Abstract Sleep problems are one of the most common health concerns among parents of young children. Adequate sleep is important to normal growth and development and persistent early childhood sleep problems impact a host of behavioral, cognitive, and physical health outcomes, with potential lifelong consequences. Studies demonstrate a higher prevalence of sleep disturbances in racial/ethnic minorities, particularly African Americans and Latinos when compared to whites, independent of socioeconomic status. The etiology of sleep difficulties emerging in early life, as well as observed disparities, remain largely unknown. Sleep can be conceptualized as “a complex phenotype of developmental neural plasticity”. Development of the neural architecture of sleep begins in utero, through a sequence of carefully orchestrated stages. When the fetus is exposed to environmental neurotoxins, central nervous system programming, including the neural connectivity framework involved in sleep regulation, can be disrupted resulting in altered sleep architecture and efficiency in early childhood. Associations between prenatal neurotoxins and postnatal sleep disorders may depend on timing of exposure as well as dose. Candidate neurotoxins include prenatal exposure to ambient fine particulate matter (PM2.5) and maternal stress. Moreover, effects of prenatal pollution can be enhanced by concomitant exposure to stress. Neurodevelopmental effects of in utero exposure to ambient air pollutants can be further modified by race/ethnicity or fetal sex. Early life temperament traits are also important determinants of emerging behavior problems including disordered sleep, with studies showing both mediating and moderating effects on associations between environmental risk factors and sleep behaviors. We leverage a longitudinal urban multi-ethnic pregnancy cohort (n=450 mother-child pairs), with detailed characterization of prenatal exposure to ambient PM2.5, maternal psychological stress (lifetime and current adverse life events, maternal psychological functioning, and biological stress response indexed by maternal hair cortisol), and infant temperament, to begin to examine associations among these factors and childhood sleep outcomes. This initiative will support sleep phenotyping at age 4-5 years, ascertained through standardized parent- reported sleep questionnaires/diaries, wearable accelerometers, and in-home polysomnography (PSG) in order to: (1) examine associations between prenatal PM2.5 exposure and adverse child sleep outcomes, accounting for timing of exposure; (2) examine whether maternal stress and psychobiological correlates, assessed in pregnancy, considered independently and as mixtures, predict adverse child sleep outcomes; (3) examine whether PM2.5 effects are modified by prenatal stress; (4) explore whether these associations are further modified by i) race/ethnicity or ii) fetal sex; and (5) examine whether prenatal air pollution and/or stress effects are mediated and/or modified by difficult temperament in infancy. Findings may begin to elucidate how interactions among social and physical environments contribute to early childhood sleep disparities.

项目摘要/摘要睡眠问题是幼儿父母中最常见的健康问题之一。足够的睡眠对正常的生长和发展至关重要，持续的儿童睡眠问题会影响行为，认知和身体健康成果的主持人可能会带来潜在的终生后果。研究在种族/族裔少数群体，尤其是非洲人中表现出较高的睡眠障碍患病率与白人相比，美国人和拉丁美洲人与社会经济地位无关。睡眠的病因早期生活的困难以及观察到的差异仍然在很大程度上未知。睡眠可以概念化为“发育神经元可塑性的复杂表型”。神经元的发展睡眠结构始于子宫，通过一系列精心策划的阶段开始。当胎儿是暴露于环境神经毒素，中枢神经系统编程，包括神经连接性涉及睡眠调节的框架，可能会破坏，从而改变睡眠结构和效率的改变幼儿。产前神经毒素和产后睡眠障碍之间的关联可能取决于暴露时间和剂量。候选神经毒素包括产前暴露于环境细胞颗粒物（PM2.5）和母子应力。此外，可以通过伴随着压力。子宫内暴露于环境空气污染物的神经发育影响可以通过种族/种族或胎儿性别进一步修改。早期寿命的特征也是重要的决定者新兴行为问题在内，包括睡眠无序，研究表明介导和调节对环境风险因素与睡眠行为之间关联的影响。我们利用a 纵向城市多种族怀孕队列（n = 450个母子对），详细表征产前暴露于环境PM2.5，孕产妇心理压力（生命周期和当前的不良生活事件，母体心理功能以及由母体头发皮质醇索引的生物压力反应）和婴儿温度，开始检查这些因素和儿童睡眠结果之间的关联。该倡议将通过标准化的父母来确定4-5岁的睡眠表型报告的睡眠问卷/日记，可穿戴加速度计和内部多聚会学（PSG）命令：（1）检查产前PM2.5暴露与不良儿童睡眠结局之间的关联，考虑暴露时间；（2）检查物质压力和心理生物学是否相关，在怀孕中评估，被视为独立的混合物，可以预测儿童睡眠不良的结果；（3）检查PM2.5是否通过产前应力来改变效果；（4）探索这些关联是否是 i）种族/民族或ii）胎儿性别进一步修改；（5）检查产前空气污染和/或压力是否效应是通过婴儿期难度的困难介导和/或修饰的。调查结果可能开始阐明如何社会和身体环境之间的相互作用导致幼儿睡眠差异。