RNA Science and Technology in Health and Disease

RNA科学与技术在健康和疾病中的应用

• 批准号: 10189657
• 负责人: MARLENE BELFORT
• 金额: $ 25.76万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10189657
• 关键词: Disease; Health; RNA; Science; Technology

1. PROJECT SUMMARY The overall goal of the RNA Fellows program is to rigorously train graduate students for careers in science and technology companies, science communication organizations, public service or academia. Our RNA Fellows will plan and execute RNA centric research projects and actively participate in year-long business plan competitions or writing events, so that they can be qualified as science entrepreneurs or science communicators. These unique experiences will help our students bring their science based training to the pharmaceutical, biotechnology, business start-up, finance, public policy, journalism and other non-traditional fields. Our distinctive T32 training grant is designed to train students for careers outside academia, but it will allow them to excel in traditional post-doctoral environments if they so choose. We will prepare students to harness the potential of RNA science and technology by cross-training in chemical, molecular, nanoscale science, and public health disciplines, as we exploit the intellectual capital and the resources of the RNA Institute with members from University at Albany, SUNY (State University of New York) and SUNY Polytechnic Institute. The RNA Fellows program will give students in four departmental degree programs, Biological Sciences, Biomedical Sciences, Chemistry and Nanobiosciences, unique research and educational experiences that will provide the professional and personal skills to meet the challenges needed for a cutting edge science and technology workforce. Doctoral research projects will extend from the fundamental biology of RNA in gene-expression, health and disease to technology innovation at the interfaces of biology, chemistry, biophysics, computation, nanoscale science, nanoscale engineering and informatics. There are six RNA research themes representing mentor faculty interests (i) Computational Analysis of RNA Structure; (ii) Experimental Analysis of RNA Sequence and Structure; (iii) Technology Development; and three biomedical themes of (i) Basic Cellular Processes; (ii) Infectious Disease; and (iii) Development and Cancer. A two- semester flagship RNA course based on these themes and a course in mathematical or biomedical fluency will be combined with options to train in entrepreneurship or writing, via the Blackstone Entrepreneurship Launchpad at our School of Business or at the renowned NY State Writers Institute, respectively. As evidence of Institutional support, we have implemented a SUNY sponsored RNA Fellows program that has 18 total students from three yearly cohorts. The 33 training faculty have on average over $372K a year in direct grant support and focus on our RNA core themes. UAlbany has a strong commitment to student diversity with 29.9% of its students being under-represented minorities. Together with an existing aggressive recruitment plan, our current demographics and our participation in the New York Louis Stokes Alliance for Minority Participation (LSAMP) positons us to grow our recruitment of individuals from underrepresented backgrounds. Our T32 training grant application requests funding for 20 student slots, which is matched with over $1 million from SUNY in institutional support. !

1. 项目概要 RNA 研究员计划的总体目标是严格培训研究生，使其能够从事以下领域的职业： 科技公司、科学传播组织、公共服务或学术界。我们的 RNA 研究员将规划和执行以 RNA 为中心的研究项目，并积极参与为期一年的业务 策划竞赛或写作活动，使他们有资格成为科学企业家或科学 沟通者。这些独特的经历将帮助我们的学生将他们的科学培训带入 制药、生物技术、创业、金融、公共政策、新闻和其他非传统 字段。我们独特的 T32 培训补助金旨在培训学生从事学术界以外的职业，但它会 如果他们愿意的话，让他们在传统的博士后环境中表现出色。我们将帮助学生做好准备 通过化学、分子、纳米尺度的交叉训练来利用RNA科学和技术的潜力 当我们利用 RNA 的智力资本和资源时，科学和公共卫生学科 研究所成员来自奥尔巴尼大学、纽约州立大学（纽约州立大学）和纽约州立大学理工学院 研究所。 RNA 研究员计划将为学生提供四个院系学位课程：生物学 科学、生物医学、化学和纳米生物科学、独特的研究和教育 经验将提供专业和个人技能来应对切割所需的挑战 尖端科技劳动力。博士研究项目将从基础生物学延伸 RNA在基因表达、健康和疾病中的作用以及生物学、化学、 生物物理学、计算、纳米科学、纳米工程和信息学。有 6 个 RNA 代表导师教师兴趣的研究主题 (i) RNA 结构的计算分析； (二) RNA序列和结构的实验分析； (iii) 技术开发；以及三个生物医学 (i) 基本细胞过程的主题； (二) 传染病； (iii) 发育与癌症。一个二- 基于这些主题的学期旗舰 RNA 课程以及数学或生物医学流利课程将 通过 Blackstone Entrepreneurship 与创业或写作培训选项相结合 分别在我们的商学院或著名的纽约州立作家学院启动。作为证据 为了获得机构支持，我们实施了纽约州立大学赞助的 RNA 研究员计划，共有 18 名 来自三个年度队列的学生。 33 名培训教师每年平均获得超过 372,000 美元的直接拨款 支持并专注于我们的 RNA 核心主题。阿尔巴尼大学坚定地致力于学生多元化 29.9% 的学生是少数族裔。加上现有的积极招聘 计划、我们当前的人口统计数据以及我们对纽约路易斯斯托克斯少数族裔联盟的参与 参与 (LSAMP) 使我们能够增加对来自代表性不足背景的个人的招募。 我们的 T32 培训补助金申请要求为 20 个学生名额提供资金，配套金额超过 100 万美元 来自纽约州立大学的机构支持。 ！