RNA Science and Technology in Health and Disease

RNA科学与技术在健康和疾病中的应用

• 批准号: 10670064
• 负责人: MARLENE BELFORT
• 金额: $ 21.52万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670064
• 关键词: Disease; Health; RNA; Science; Technology

1. PROJECT SUMMARY The overall goal of the RNA Fellows program is to rigorously train graduate students for careers in science and technology companies, science communication organizations, public service or academia. Our RNA Fellows will plan and execute RNA centric research projects and actively participate in year-long business plan competitions or writing events, so that they can be qualified as science entrepreneurs or science communicators. These unique experiences will help our students bring their science based training to the pharmaceutical, biotechnology, business start-up, finance, public policy, journalism and other non-traditional fields. Our distinctive T32 training grant is designed to train students for careers outside academia, but it will allow them to excel in traditional post-doctoral environments if they so choose. We will prepare students to harness the potential of RNA science and technology by cross-training in chemical, molecular, nanoscale science, and public health disciplines, as we exploit the intellectual capital and the resources of the RNA Institute with members from University at Albany, SUNY (State University of New York) and SUNY Polytechnic Institute. The RNA Fellows program will give students in four departmental degree programs, Biological Sciences, Biomedical Sciences, Chemistry and Nanobiosciences, unique research and educational experiences that will provide the professional and personal skills to meet the challenges needed for a cutting edge science and technology workforce. Doctoral research projects will extend from the fundamental biology of RNA in gene-expression, health and disease to technology innovation at the interfaces of biology, chemistry, biophysics, computation, nanoscale science, nanoscale engineering and informatics. There are six RNA research themes representing mentor faculty interests (i) Computational Analysis of RNA Structure; (ii) Experimental Analysis of RNA Sequence and Structure; (iii) Technology Development; and three biomedical themes of (i) Basic Cellular Processes; (ii) Infectious Disease; and (iii) Development and Cancer. A two- semester flagship RNA course based on these themes and a course in mathematical or biomedical fluency will be combined with options to train in entrepreneurship or writing, via the Blackstone Entrepreneurship Launchpad at our School of Business or at the renowned NY State Writers Institute, respectively. As evidence of Institutional support, we have implemented a SUNY sponsored RNA Fellows program that has 18 total students from three yearly cohorts. The 33 training faculty have on average over $372K a year in direct grant support and focus on our RNA core themes. UAlbany has a strong commitment to student diversity with 29.9% of its students being under-represented minorities. Together with an existing aggressive recruitment plan, our current demographics and our participation in the New York Louis Stokes Alliance for Minority Participation (LSAMP) positons us to grow our recruitment of individuals from underrepresented backgrounds. Our T32 training grant application requests funding for 20 student slots, which is matched with over $1 million from SUNY in institutional support. !

1。项目摘要 RNA研究员​​计划的总体目标是严格培训研究生的职业 科学技术公司，科学传播组织，公共服务或学术界。我们的 RNA研究员​​将计划和执行以RNA为中心的研究项目，并积极参加为期一年的业务 计划比赛或写作活动，以便他们可以成为科学企业家或科学的资格 沟通者。这些独特的经历将帮助我们的学生将基于科学的培训带到 药物，生物技术，业务初创企业，金融，公共政策，新闻和其他非传统 字段。我们独特的T32培训补助金旨在培训学生在学术界以外的职业，但它将 如果他们选择的话，让他们可以在传统的博士后环境中表现出色。我们将为学生做好准备 利用化学，分子，纳米级的交叉训练来利用RNA科学和技术的潜力 当我们利用RNA的智力资本和资源时，科学和公共卫生学科 学院与奥尔巴尼，纽约州立大学奥尔巴尼大学的成员和纽约州立大学理工学院的成员 研究所。 RNA研究员​​计划将为学生提供四个部门学位课程，生物学 科学，生物医学科学，化学和纳米型，独特的研究和教育 将提供专业和个人技能的经验，以应对切割所需的挑战 边缘科学和技术劳动力。博士研究项目将从 基因表达，健康和疾病的RNA在生物学，化学，化学界面的技术创新中 生物物理学，计算，纳米级科学，纳米级工程和信息学。有六个RNA 代表导师教师利益的研究主题（i）RNA结构的计算分析； （ii） RNA序列和结构的实验分析； （iii）技术开发；和三个生物医学 （i）基本蜂窝过程的主题； （ii）传染病； （iii）发展和癌症。两个 基于这些主题的学期旗舰RNA课程以及数学或生物医学流利的课程将 通过黑石企业家精神与企业家或写作训练的选择结合在一起 分别在我们的商学院或著名的纽约州作家学院的发射台。作为证据 在机构支持中，我们实施了一个纽约州立大学赞助的RNA研究员​​计划，该计划总共有18个 来自三年一年的学生。 33位培训教师平均每年的直接赠款超过37.2万美元 支持并专注于我们的RNA核心主题。 Ualbany对学生多样性有着坚定的承诺 29.9％的学生人数不足。以及现有的积极招聘 计划，我们目前的人口统计以及我们参加纽约路易斯·斯托克斯少数民族联盟 参与（LSAMP）认为我们从代表性不足的背景中增加个人的招聘。 我们的T32培训赠款申请要求为20个学生老虎机提供资金，与超过100万美元相匹配 来自纽约州立大学的机构支持。 呢