RNA Science and Technology in Health and Disease

RNA科学与技术在健康和疾病中的应用

• 批准号: 10670064
• 负责人: MARLENE BELFORT
• 金额: $ 21.52万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670064
• 关键词: Disease; Health; RNA; Science; Technology

1. PROJECT SUMMARY The overall goal of the RNA Fellows program is to rigorously train graduate students for careers in science and technology companies, science communication organizations, public service or academia. Our RNA Fellows will plan and execute RNA centric research projects and actively participate in year-long business plan competitions or writing events, so that they can be qualified as science entrepreneurs or science communicators. These unique experiences will help our students bring their science based training to the pharmaceutical, biotechnology, business start-up, finance, public policy, journalism and other non-traditional fields. Our distinctive T32 training grant is designed to train students for careers outside academia, but it will allow them to excel in traditional post-doctoral environments if they so choose. We will prepare students to harness the potential of RNA science and technology by cross-training in chemical, molecular, nanoscale science, and public health disciplines, as we exploit the intellectual capital and the resources of the RNA Institute with members from University at Albany, SUNY (State University of New York) and SUNY Polytechnic Institute. The RNA Fellows program will give students in four departmental degree programs, Biological Sciences, Biomedical Sciences, Chemistry and Nanobiosciences, unique research and educational experiences that will provide the professional and personal skills to meet the challenges needed for a cutting edge science and technology workforce. Doctoral research projects will extend from the fundamental biology of RNA in gene-expression, health and disease to technology innovation at the interfaces of biology, chemistry, biophysics, computation, nanoscale science, nanoscale engineering and informatics. There are six RNA research themes representing mentor faculty interests (i) Computational Analysis of RNA Structure; (ii) Experimental Analysis of RNA Sequence and Structure; (iii) Technology Development; and three biomedical themes of (i) Basic Cellular Processes; (ii) Infectious Disease; and (iii) Development and Cancer. A two- semester flagship RNA course based on these themes and a course in mathematical or biomedical fluency will be combined with options to train in entrepreneurship or writing, via the Blackstone Entrepreneurship Launchpad at our School of Business or at the renowned NY State Writers Institute, respectively. As evidence of Institutional support, we have implemented a SUNY sponsored RNA Fellows program that has 18 total students from three yearly cohorts. The 33 training faculty have on average over $372K a year in direct grant support and focus on our RNA core themes. UAlbany has a strong commitment to student diversity with 29.9% of its students being under-represented minorities. Together with an existing aggressive recruitment plan, our current demographics and our participation in the New York Louis Stokes Alliance for Minority Participation (LSAMP) positons us to grow our recruitment of individuals from underrepresented backgrounds. Our T32 training grant application requests funding for 20 student slots, which is matched with over $1 million from SUNY in institutional support. !

1.项目总结 RNA研究员计划的总体目标是严格培训研究生，使其在 科技公司、科学传播组织、公共服务或学术界。我们的 RNA研究员将计划和执行以RNA为中心的研究项目，并积极参与为期一年的业务 策划竞赛或写作活动，这样他们才有资格成为科学企业家或科学工作者 传播者。这些独特的体验将帮助我们的学生将他们的科学培训带到 制药、生物技术、创业、金融、公共政策、新闻等非传统行业 菲尔兹。我们独特的T32培训补助金旨在为学生在学术界以外的职业生涯培训学生，但它将 允许他们在传统的博士后环境中出类拔萃，如果他们愿意的话。我们将让学生们做好准备 通过在化学、分子、纳米尺度上的交叉培训来利用RNA科学和技术的潜力 科学和公共卫生学科，因为我们开发智力资本和RNA的资源 协会成员来自奥尔巴尼大学、纽约州立大学和纽约州立大学理工学院 研究所。RNA研究员项目将为四个系学位项目的学生提供生物学 科学、生物医学、化学和纳米生物科学、独特的研究和教育 将提供专业和个人技能以应对切割所需挑战的经验 尖端科技人才队伍。博士研究项目将从基础生物学延伸到 从基因表达、健康和疾病的RNA到生物、化学、 生物物理学、计算、纳米科学、纳米工程和信息学。有六种核糖核酸 代表导师兴趣的研究主题(I)RNA结构的计算分析；(Ii) RNA序列和结构的实验分析；(Iii)技术发展；以及三个生物医学 主题：(I)基本细胞过程；(Ii)传染病；(Iii)发育与癌症。两个人- 基于这些主题的学期旗舰RNA课程和数学或生物医学流利性课程将 通过Blackstone Entretreurship与创业或写作方面的培训选项相结合 LaunchPad分别在我们的商学院或著名的纽约州立作家学院。作为证据 在机构支持方面，我们实施了纽约州立大学赞助的RNA研究员计划，共有18个 来自三个年度队列的学生。33名培训教师平均每年有超过372,000美元的直接补助金 支持并专注于我们的RNA核心主题。UAlbany大学坚定地致力于学生多样性， 29.9%的学生是代表不足的少数族裔。再加上现有的积极招聘 计划、我们目前的人口结构以及我们对纽约路易斯·斯托克斯少数民族联盟的参与 参与(LSAMP)有助于我们更多地招募来自代表性不足背景的个人。 我们的T32培训补助金申请申请了20个学生名额，与之相匹配的是100多万美元 来自纽约州立大学的机构支持。 好了！