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RNA Modifications in Health and Disease

健康和疾病中的 RNA 修饰

基本信息

批准号：
10754076
负责人：
TERRY L. SHEPPARD
金额：
$ 0.75万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10754076
关键词：
Acceleration Antisense Oligonucleotides Area Automobile Driving Biological Biological Process Biology COVID-19 vaccine Canada Chemicals Clinic Collaborations Data Development Disease Disease model Educational workshop Environment Enzymes Epigenetic Process Fostering Friends Future Genetic Transcription Health Human Immunity Industrialization Infection Joints Knowledge Learning Literature Medicine Messenger RNA Methodology Modification Motivation Natural Immunity Nucleotides Outcome Participant Pathway interactions Pharmaceutical Preparations Postdoctoral Fellow Proteins RNA RNA Sequences Reader Regulation Research Research Personnel Role Scientist Site Structure Technology Therapeutic Intervention Translating Translational Research Viral Cancer Virus Diseases Work benefit sharing clinical practice data standards doctoral student epitranscriptome epitranscriptomics improved interest meetings method development model organism multidisciplinary new technology patient engagement posters symposium targeted treatment technology development transcriptome translational potential

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled RNA Modifications in Health and Disease, organized by Drs. Eric Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo. The conference will be held in Banff, Canada from December 12-15, 2023. Chemical modifications of RNA nucleotides, collectively referred to as the epitranscriptome, represent an additional layer of information encoded in transcribed RNA sequences. By analogy to epigenetic mechanisms, RNA modifications are reversibly added by ‘writer’ and ‘eraser’ enzymes and these ‘marks’ are interpreted by ‘reader’ proteins. Characterization of the structural diversity of RNA modifications and elucidation of their roles in biological pathways represent central motivations of this emerging field, which has been supported by new technology development and mechanistic analysis by scientists interested in RNA biology. Basic discoveries in epitranscriptomics are being translated toward the clinic at an accelerating rate. Our understanding of the function and regulation of RNA modifications, as well as their roles in human infection, immunity and disease is deepening in parallel with the advancement of RNA-based medicines, such as mRNA-based COVID-19 vaccines or antisense oligonucleotides (ASOs). This conference will bring together leading experts focused on RNA modifications, technology development and medicine to discuss cutting edge research, evaluate data standards in the field and identify opportunities for the translational potential of targeting RNA modification pathways. We anticipate that participants of this conference will benefit by sharing results on this rapidly advancing topic, but also in defining the future direction of the field and creating new collaborations to accelerate progress.

摘要