RNA Modifications in Health and Disease

健康和疾病中的 RNA 修饰

• 批准号: 10754076
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.75万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10754076
• 关键词: Acceleration; Antisense Oligonucleotides; Area; Automobile Driving; Biological; Biological Process; Biology; COVID-19 vaccine; Canada; Chemicals; Clinic; Collaborations; Data; Development; Disease; Disease model; Educational workshop; Environment; Enzymes; Epigenetic Process; Fostering; Friends; Future; Genetic Transcription; Health; Human; Immunity; Industrialization; Infection; Joints; Knowledge; Learning; Literature; Medicine; Messenger RNA; Methodology; Modification; Motivation; Natural Immunity; Nucleotides; Outcome; Participant; Pathway interactions; Pharmaceutical Preparations; Postdoctoral Fellow; Proteins; RNA; RNA Sequences; Reader; Regulation; Research; Research Personnel; Role; Scientist; Site; Structure; Technology; Therapeutic Intervention; Translating; Translational Research; Viral Cancer; Virus Diseases; Work; benefit sharing; clinical practice; data standards; doctoral student; epitranscriptome; epitranscriptomics; improved; interest; meetings; method development; model organism; multidisciplinary; new technology; patient engagement; posters; symposium; targeted treatment; technology development; transcriptome; translational potential

ABSTRACT Support is requested for a Keystone Symposia conference entitled RNA Modifications in Health and Disease, organized by Drs. Eric Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo. The conference will be held in Banff, Canada from December 12-15, 2023. Chemical modifications of RNA nucleotides, collectively referred to as the epitranscriptome, represent an additional layer of information encoded in transcribed RNA sequences. By analogy to epigenetic mechanisms, RNA modifications are reversibly added by ‘writer’ and ‘eraser’ enzymes and these ‘marks’ are interpreted by ‘reader’ proteins. Characterization of the structural diversity of RNA modifications and elucidation of their roles in biological pathways represent central motivations of this emerging field, which has been supported by new technology development and mechanistic analysis by scientists interested in RNA biology. Basic discoveries in epitranscriptomics are being translated toward the clinic at an accelerating rate. Our understanding of the function and regulation of RNA modifications, as well as their roles in human infection, immunity and disease is deepening in parallel with the advancement of RNA-based medicines, such as mRNA-based COVID-19 vaccines or antisense oligonucleotides (ASOs). This conference will bring together leading experts focused on RNA modifications, technology development and medicine to discuss cutting edge research, evaluate data standards in the field and identify opportunities for the translational potential of targeting RNA modification pathways. We anticipate that participants of this conference will benefit by sharing results on this rapidly advancing topic, but also in defining the future direction of the field and creating new collaborations to accelerate progress.

摘要 要求支持一个题为“健康和疾病中的RNA修饰”的基石专题讨论会， 由Eric Miska博士、Ramesh S. Pillai和伊娃Maria Novoa Pardo。会议将于 班夫，加拿大，2023年12月12日至15日。 RNA核苷酸的化学修饰，统称为表转录组，代表了一种新的修饰方式。 在转录的RNA序列中编码的附加信息层。通过类比表观遗传机制， RNA修饰是由“写入”和“擦除”酶可逆地添加的，这些“标记”由 “阅读器”蛋白。RNA修饰结构多样性的表征及其作用的阐明 在生物学途径中的作用代表了这一新兴领域的中心动机，这一新兴领域得到了新的 对RNA生物学感兴趣的科学家的技术开发和机制分析。基本发现 表观转录组学正以加速的速度向临床转化。我们理解 RNA修饰的功能和调节，以及它们在人类感染、免疫和疾病中的作用， 与基于RNA的药物（如基于mRNA的COVID-19疫苗）的进步同步深化 或反义寡核苷酸（ASO）。本次会议将汇集专注于RNA的领先专家 修改，技术开发和医学讨论前沿研究，评估数据标准 并确定靶向RNA修饰途径的翻译潜力的机会。我们 我预计，本次会议的与会者将受益于分享这一迅速发展的主题的成果，但 此外，在确定该领域的未来方向和建立新的合作，以加快进展。