Exposure Biology Informatics Facility Core

暴露生物学信息学核心（EBIC）：摘要 暴露生物学信息学核心（EBIC）致力于为CEET提供信息学支持 化学信息学资源管理和分析，生物信息学应用领域的研究人员 开发、多组学数据管理和整合、下一代测序（NGS）数据分析， 从电子健康记录（EHR）中提取数据的生物医学信息学，计算机编程， 人工智能和机器学习以及数据可视化。为此目的，我们已组织了一个 拥有计算机科学、数据科学和基因组学互补技能的多元化专家团队， 强大的信息学基础设施，为生物医学和环境大数据做好准备。的愿景 EBIC将为创新计算方法的日常使用提供无缝支持， 暴露生物学和环境健康的复杂性，并将大数据转化为知识 精准公共卫生（PPH）EBIC的一个中心目标是与CEET调查人员密切合作 在这两个合作和支持的作用，以了解不良后果的途径（AOP）或结构， 从暴露于分子起始事件到生物体和人群健康的下游关键事件 结果。EBIC的主要目标围绕八个具体目标组织。目标1：我们将提供 为研究小组提供最先进的信息学服务，否则这些研究小组将无法访问这些计算 接近。目标2：我们将支持CEET在空气污染和肺部健康、环境保护、 暴露与癌症，易感性窗口和环境神经科学与信息学服务。在 目标3：我们将通过优先级优化EBIC服务。目标4：我们将支持CEET试点项目 信息服务。目标5：我们将提供最先进的计算设备， 软件目标6：我们将确保EBIC支持综合健康科学设施的活动 核心和翻译生物标志物核心，为人类受试者/人群研究提供信息学支持。在 目标7：我们将提供信息学方面的教育机会和培训， 早期调查员。目标8：我们将向更大的国家传播信息学、数据软件和新工具， 环境卫生科学社区。

EXPOSURE BIOLOGY INFORMATICS CORE (EBIC): ABSTRACT The Exposure Biology Informatics Core (EBIC) is dedicated to providing informatics support to CEET investigators in the areas of chemoinformatics resource management and analysis, bioinformatics application development, multi-omics data management and integration, next-generation sequencing (NGS) data analysis, biomedical informatics to extract data from the Electronic Health Record (EHR), computer programming, artificial intelligence and machine learning, and data visualization. For this purpose, we have assembled a diverse team of experts with complementary skills in computer science, data science, and genomics to build a powerful informatics infrastructure that is prepared for biomedical and environmental big-data. The vision for EBIC is to provide seamless support for routine use of innovative computational methods that embrace the complexity of exposure biology and environmental health and enable the conversion of big-data into knowledge to advance Precision Public Health (PPH). A central goal of the EBIC is to work closely with CEET investigators in both a collaborative and support role to understand adverse outcome pathways (AOP) or constructs that go from the exposure to molecular initiating events to downstream key events to organism and population health outcomes. The primary objectives of the EBIC are organized around eight specific aims. In Aim 1: we will provide state-of-art informatics services to research groups that otherwise would not have access to these computational approaches. In Aim 2: We will support the CEET thematic areas in Air Pollution & Lung Health, Environmental Exposures & Cancer, Windows-of-Susceptibility, and Environmental Neuroscience with informatics services. In Aim 3: We will optimize EBIC services through prioritization. In Aim 4: We will support the CEET pilot projects with informatics services. In Aim 5: We will provide access to state-of-the-art computational equipment and software. In Aim 6: We will ensure that EBIC supports the activities of the Integrative Health Sciences Facility Core and the Translational Biomarker Core with informatics support for human subject/population research. In Aim 7: We will provide educational opportunities and training in informatics which is an optional experience for Early Stage Investigators. In Aim 8: We will disseminate informatics, data software and new tools to the larger environmental health sciences community .