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Evidence-based Approaches to Chronic Pain Management in Youth with Sickle Cell Disease

镰状细胞病青少年慢性疼痛管理的循证方法

基本信息

批准号：
10200878
负责人：
Soumitri Sil
金额：
$ 14.88万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10200878
关键词：
Address Adolescent Affect African American Aftercare Age Automobile Driving Behavior Therapy Behavioral Caregiver Burden Caregivers Caring Caucasians Child Child health care Childhood Chronic Clinical Clinical Investigator Clinical Research Clinical Trials Cognitive Cognitive Therapy Communities Complex Data Development Development Plans Effectiveness Emergency Care Emergency department visit Enrollment Ensure Evaluation Evidence based intervention Evidence based treatment Family Feedback Focus Groups Frequencies Future Goals Health Health Care Costs Health Personnel Healthcare Hospitalization Individual Infrastructure Inpatients Instruction International Intervention Interview Knowledge Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Mind-Body Intervention Modeling Outcome Pain Pain interference Pain management Parents Pattern Pharmacology Physiology Prevention Psychosocial Factor Qualitative Methods Quality of life Reach, Effectiveness, Adoption, Implementation, and Maintenance Research Research Project Grants Research Training Risk Factors Sickle Cell Sickle Cell Anemia Stress Testing Time Training Universities Youth acceptability and feasibility adaptive intervention aged anxiety symptoms base biobehavior biopsychosocial factor career career development chronic pain chronic pain management chronic painful condition clinically significant cohort comorbidity coping depressive symptoms disability effective therapy evidence base experience flexibility follow-up health disparity health related quality of life implementation science improved individualized medicine informant innovation intervention program iterative design novel opioid use pain reduction patient oriented pediatric patients prevent programs psychologic psychosocial racial disparity racism risk stratification satisfaction secondary outcome social culture socioeconomic disparity success therapeutically effective therapy development

项目摘要

PROJECT SUMMARY Chronic pain is a complex and challenging problem associated with significant disability and suffering among children and adolescents with sickle cell disease (SCD). There is a gap in scientific knowledge in understanding the progression of chronic SCD pain that hinders the development of effective therapeutic options. Psychological treatments are key components of comprehensive chronic pain management, but currently have limited efficacy for managing SCD pain in youth. Thus, the long-term career goal of this candidate is to become an independent clinical investigator with expertise in SCD pain to establish a novel stepped care model of delivering behavioral interventions for SCD pain management that are easily implemented in real-world clinical settings. She will begin to achieve these goals by obtaining clinical and research training in SCD pain physiology and pharmacology and training in implementation science, health disparities research, and advanced quantitative and qualitative methods to support a patient-centered approach to pain intervention development, optimization, and evaluation. Her career development plan is uniquely tailored to fulfill gaps in her training in pediatric pain under the mentorship of national and international leaders at Emory University and Children’s Healthcare of Atlanta. The training plan leverages the well- supported infrastructure of the largest pediatric sickle cell program in the US as well as national and institutional opportunities to ensure didactic, experiential, and specialized individual instruction. The research objectives of this application are to first rigorously characterize trajectories of chronic pain over a 24-month period in a cohort of youth with SCD (ages 10-18 years). Data will help identify modifiable psychosocial and family risk factors (e.g., elevated anxiety or depressive symptoms, caregiver stress) that predict different chronic pain trajectories to inform relevant behavioral treatment targets in a family-focused cognitive-behavioral intervention. Standard qualitative and mixed-method approaches and iterative design using focus groups, key informant interviews, and community stakeholders will be used to develop and refine intervention content and format and solicit feedback to enhance the success of future implementation in clinical settings. The result will be a family-focused, culturally informed, evidence-based intervention termed Back2Living (“Building Adaptive Coping and Knowledge To improve daily Living”) that is amenable for implementation in real-world clinical settings. A pilot proof-of-concept trial will evaluate the feasibility, acceptability, and preliminary efficacy of Back2Living with youth with chronic SCD pain and their parents. An adaptive treatment approach with 4-8 treatment sessions selected on the basis of baseline assessment will target comorbid psychosocial risk factors and allow flexibility in tailoring treatment components to meet individual family needs to reduce pain interference, pain, and healthcare use. Results of this proposal may ultimately contribute to novel comprehensive treatment approaches to treat chronic pain in pediatric SCD and improve quality of life.

项目总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Enhancing Pain Assessment in Pediatric Sickle Cell Disease by Applying Quality Improvement Science.

应用质量改进科学加强小儿镰状细胞病的疼痛评估。

DOI：
10.1037/cpp0000277
发表时间：
2019
期刊：
Clinical practice in pediatric psychology
影响因子：
1.1
作者：
Sil,Soumitri;Goldstein-Leever,Alana;Travers,Curtis;Gilleland-Marchak,Jordan;Alexander,Ashley;Thompson,Beth;Griffin,Anya;McCracken,Courtney;New,Tamara
通讯作者：
New,Tamara

The distinct longitudinal impact of pain catastrophizing on pain interference among youth living with sickle cell disease and chronic pain.

DOI：
10.1007/s10865-021-00280-4
发表时间：
2022-08
期刊：
JOURNAL OF BEHAVIORAL MEDICINE
影响因子：
3.1
作者：
Schneider, Mallory B;Manikowski, Alison;Cohen, Lindsey;Dampier, Carlton;Sil, Soumitri
通讯作者：
Sil, Soumitri

The comfort ability program for adolescents with sickle cell pain: Evaluating feasibility and acceptability of an inpatient group-based clinical implementation.