MECHANISMS OF ABNORMAL EXPRESSION OF THE IGF2 GENE IN DISORDERS AFFECTING FOETAL GROWTH

影响胎儿生长的疾病中 IGF2 基因异常表达的机制

• 批准号: nhmrc : 472637
• 负责人: Dr Christine Gicquel
• 金额: $ 37.37万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-abnormal-expression-foetal-growth/101441
• 关键词: MECHANISMS; ABNORMAL; EXPRESSION; IGF2; GENE

The IGF2 gene is crucial for foetal growth. Only the copy inherited from the father is active, a phenomenon named parental imprinting. In some children with foetal overgrowth or growth retardation, the deregulation of imprinting of the IGF2 gene during the first days of foetal development will influence subsequent growth and will also have major implications in post-natal and adult life. We will investigate the mechanisms resulting in abnormal imprinting of the IGF2 early in development.

IGF2基因对胎儿生长至关重要。只有从父亲那里继承的拷贝是活跃的，这种现象被称为父母印记。在一些胎儿过度生长或生长迟缓的儿童中，在胎儿发育的第一天IGF2基因印记的失调将影响随后的生长，并且也将对出生后和成年生活产生重大影响。我们将调查的机制，导致异常印迹的IGF2在发展的早期。