Synergistic degradation of the bonded interface: A new approach to evaluate the bond strength of dental restoration

项目总结 经过近70年的研究，牙科复合材料修复体的临床应用仍然有限。 超过50%的粘结修复体在不到十年的时间内失败。病原菌 而人类唾液酶会产生有害的产品，降解牙科树脂和粘合剂。作为一名 结果，粘结强度减弱，增加了继发性龋齿的进展，过早失效 修复和牙齿脱落。目前评估生物降解源对键的影响的方法 力量无法在实验室环境中复制临床条件。我们的目标是开发一种 使用真实环境准确预测复合修复体寿命的实验方法。 我们的创新方法通过挑战不同的绑定接口显著改进了现有方法 可降解性来源同时存在。在本研究中，我们提出了寻找主要的具体贡献 降解来源(唾液酶、细菌酶和酸，以及循环机械负荷) 在降低粘合强度方面协同工作(目标1)。我们还将评估粘结强度和耐久性 牙本质/树脂复合材料在临床相关微生物群环境中的界面。这个项目将 评估在典型口腔条件下牙齿修复界面的退化情况，这将有助于 阐明主要降解源对粘结强度耐久性的单独和协同影响。 这种新方法的应用将有助于提高对复合材料耐久性的预测。 修复，从而使恢复性治疗更可预测

PROJECT SUMMARY After nearly seven decades of research, dental composites restorations continue to show limited clinical service, with more than 50% of placed bonded restorations failing in less than ten years. Pathogenic bacteria and human salivary enzymes produce detrimental products that degrade dental resins and adhesives. As a result, the bond strength is debilitated, which increases the progression of secondary caries, premature failure of restoration, and tooth loss. Current approaches to evaluate the effects of biodegradation sources on bond strength are failing to replicate clinical conditions in a laboratory setting. Our goal is to develop an experimental approach for accurately predicting composite restorations' lifetime using realistic environments. Our innovative approach significantly improves existing methods by challenging bonded interfaces to different degradative sources simultaneously. In this study, we proposed to find the specific contribution of the main degradative sources (salivary enzymes, bacteria enzymes and acids, and cyclic mechanical loading) after working in synergy on bond strength reduction (aim 1). We will also evaluate the bond strength durability of dentin/resin composites interfaces within a clinically relevant microbiome environment. This project will assess the degradation of the tooth-restoration interface under representative oral conditions and will help elucidate the individual and synergistic effects of the primary degradative sources on bond strength durability. The application of this novel approach will help improve the prediction of the durability of composite restorations, thereby rendering the restorative treatment more predictable