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Synergistic degradation of the bonded interface: A new approach to evaluate the bond strength of dental restoration

粘合界面的协同降解：评估牙科修复体粘合强度的新方法

基本信息

批准号：
10589775
负责人：
Mary Anne Sampaio de Melo
金额：
$ 15.78万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-11 至 2024-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10589775
关键词：
16S ribosomal RNA sequencing Acids Adhesives Anti-Bacterial Agents Bacteria Biocompatible Materials Biodegradation Biological Biological Models Chemicals Clinical Clinical Data Clinical Services Composite Resins Dental Dental General Practice Dental Materials Dental caries Dentin Development Economic Burden Environment Enzymes Exposure to Failure Fatigue Formulation Future Goals Human In Vitro Individual Infiltration Laboratories Mastication Mechanics Methods Microbial Biofilms Microscopy Mouth Diseases Oral health Outcome Performance Periodicity Plant Resins Policies Prevention Procedures Publishing Reproducibility Research Saliva Salivary Sampling Source Streptococcus mutans Sucrose Techniques Testing Tissues Tooth Loss Tooth structure Visual Work clinical predictors clinical translation clinically relevant combinatorial composite restoration cost dental adhesive dental resin dysbiosis healing improved in vivo innovation mechanical load microCT microbial microbiome novel strategies oral condition oral microbial community pathogenic bacteria pre-clinical predictive modeling premature remineralization restoration restorative dentistry restorative treatment synergism trigger point

项目摘要

PROJECT SUMMARY After nearly seven decades of research, dental composites restorations continue to show limited clinical service, with more than 50% of placed bonded restorations failing in less than ten years. Pathogenic bacteria and human salivary enzymes produce detrimental products that degrade dental resins and adhesives. As a result, the bond strength is debilitated, which increases the progression of secondary caries, premature failure of restoration, and tooth loss. Current approaches to evaluate the effects of biodegradation sources on bond strength are failing to replicate clinical conditions in a laboratory setting. Our goal is to develop an experimental approach for accurately predicting composite restorations' lifetime using realistic environments. Our innovative approach significantly improves existing methods by challenging bonded interfaces to different degradative sources simultaneously. In this study, we proposed to find the specific contribution of the main degradative sources (salivary enzymes, bacteria enzymes and acids, and cyclic mechanical loading) after working in synergy on bond strength reduction (aim 1). We will also evaluate the bond strength durability of dentin/resin composites interfaces within a clinically relevant microbiome environment. This project will assess the degradation of the tooth-restoration interface under representative oral conditions and will help elucidate the individual and synergistic effects of the primary degradative sources on bond strength durability. The application of this novel approach will help improve the prediction of the durability of composite restorations, thereby rendering the restorative treatment more predictable

项目总结