Finance, Cognition, and Default Network in Aging (FCDNA)

老龄化中的金融、认知和默认网络 (FDNA)

• 批准号: 10208259
• 负责人: DUKE HAN
• 金额: $ 220.45万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208259
• 关键词: Address; Adult; Age; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease risk; Anterior; Attention; Brain; Brain imaging; Brain region; Characteristics; Clinical; Coercion; Cognition; Cognitive; Decision Making; Deterioration; Disease; Early Diagnosis; Early Intervention; Economics; Elder Abuse; Elderly; Episodic memory; Genetic Risk; Goals; Health; Heterogeneity; Image; Impaired cognition; Impairment; Measurement; Measures; Medial; Methods; Neurocognitive; Neurofibrillary Tangles; Neuropsychology; Parietal; Parietal Lobe; Participant; Personal Satisfaction; Persons; Phenotype; Qualitative Research; Research; Resources; Risk; Risk Factors; Senile Plaques; Sensory; Structure; Temporal Lobe; Time; Trust; abeta accumulation; apolipoprotein E-4; base; behavioral economics; cohort; contextual factors; discounting; experience; financial decision making; financial exploitation; human old age (65+); intervention program; mild cognitive impairment; neglect; neuropathology; pre-clinical; preference; recruit; social; tool

PROJECT SUMMARY/ABSTRACT Cognitive decline is considered the greatest risk factor for financial exploitation in old age; yet, the financial defrauding of cognitively-intact older adults is well-documented, and the reasons for this are poorly understood. We believe that financial exploitation due to poor decision making in old age may be an early functional harbinger of cognitive decline, mild cognitive impairment, and Alzheimer’s Disease. Alzheimer’s Disease is defined neuropathologically by accumulation of beta amyloid plaques and neurofibrillary tangles, and a network of medial frontal, temporal, and parietal brain regions identified as the Default Network is particularly susceptible to this age-associated neuropathology. Cortical deterioration in the posterior Default Network (parietal and temporal lobes) occurs early in Alzheimer’s Disease, and since these regions subserve episodic memory functions, these also decline early in the disease. However, it is also known that neuropathological accumulation occurs early in medial frontal brain regions, the anterior portion of the Default Network. Although medial frontal brain regions do not deteriorate structurally until later in the course of the disease, neuropathological accumulation has been shown to impact functional connectivity of brain regions, and correspondingly brain function, ahead of brain structure. Thus, early neuropathological accumulation in the medial frontal brain networks may impact associated functions, and importantly, these medial frontal networks are integral for financial decision making. In practice, clinical neuropsychological assessment batteries have traditionally neglected consideration of medial frontal brain network functions, despite the fact that in preclinical Alzheimer’s Disease changes in these medial frontal network functions may coincide or even precede noticeable episodic memory changes. Behavioral economic preference measures in relation to time, risk, and trust are tools that appear particularly sensitive to medial frontal brain network functions, and the use of these in combination with common neurocognitive measurement approaches may offer a more sensitive and comprehensive approach to assessing early brain changes leading to Alzheimer’s Disease. The overall goal of this study is to examine the association of financial exploitation in old age with markers of Alzheimer’s Disease. We hypothesize the experience of financial exploitation due to poor decision making is associated with greater cognitive decline, greater change in behavioral economic preferences, greater deterioration in anterior Default Network (medial frontal network) functional brain imaging measures, and greater Alzheimer’s Disease genetic risk. Given significant heterogeneity in the causes, contextual factors, and consequences of financial exploitation in old age to consider, qualitative research approaches to phenotype exploitation episodes will be integrated with quantitative methods to more accurately identify exploitation experiences attributable to poor financial decision making as opposed to other reasons. Findings will inform early detection and intervention programs focused on cognitive health and wellbeing in old age.

项目总结/摘要 认知能力下降被认为是老年人经济剥削的最大风险因素;然而， 对认知完整的老年人进行欺诈的情况有充分的记录，但人们对其原因知之甚少。 我们认为，由于老年决策能力差而造成的经济剥削可能是一种早期功能性疾病， 认知能力下降、轻度认知障碍和阿尔茨海默病的先兆。阿尔茨海默病是 在神经病理学上定义为β淀粉样蛋白斑块和神经纤维缠结的积累， 内侧额叶、颞叶和顶叶大脑区域被确定为默认网络， 易受这种年龄相关的神经病理学影响。后默认网络中的皮质退化 （顶叶和颞叶）发生在阿尔茨海默病的早期，由于这些区域有助于偶发性 记忆功能，这些也在疾病早期下降。然而，也知道神经病理学 累积发生在内侧额叶脑区的早期，默认网络的前部。虽然 内侧额叶脑区域直到疾病过程的后期才在结构上恶化， 神经病理学积累已被证明会影响大脑区域的功能连接， 相应地，大脑功能先于大脑结构。因此，早期的神经病理学积累， 内侧额叶脑网络可能会影响相关功能，重要的是，这些内侧额叶网络 是财务决策不可或缺的一部分。在实践中，临床神经心理学评估电池有 传统上忽视了内侧额叶脑网络功能的考虑，尽管在临床前 阿尔茨海默氏病的这些内侧额叶网络功能的变化可能与阿尔茨海默氏病的发生同时发生，甚至先于阿尔茨海默氏病的发生。 明显的情景记忆变化行为经济学偏好测量与时间、风险和 信任是对内侧额叶脑网络功能特别敏感的工具， 结合常见的神经认知测量方法可以提供更灵敏， 评估导致阿尔茨海默病的早期大脑变化的综合方法。的总目标 本研究旨在探讨老年人的经济剥削与阿尔茨海默氏症标志物之间的关系。 我们假设，由于决策失误而导致的金融剥削的经历与更大的 认知能力下降，行为经济偏好的变化更大，前违约的恶化更大 网络（内侧额叶网络）脑功能成像测量，与阿尔茨海默病遗传有关 风险鉴于金融危机的原因、背景因素和后果具有显著的异质性， 剥削在老年考虑，定性研究方法，表型剥削事件将是 与定量方法相结合，更准确地确定可归因于穷人的剥削经历， 财务决策与其他原因相反。调查结果将为早期发现和干预提供信息 专注于老年认知健康和福祉的项目。

项目成果

Quantification of race/ethnicity representation in Alzheimer's disease neuroimaging research in the USA: a systematic review.

• DOI: 10.1038/s43856-023-00333-6
• 发表时间: 2023-07-25
• 期刊: COMMUNICATIONS MEDICINE
• 作者: Lim, Aaron C;Barnes, Lisa L;Weissberger, Gali H;Lamar, Melissa;Nguyen, Annie L;Fenton, Laura;Herrera, Jennifer;Han, S Duke
• 通讯作者: Han, S Duke

Interpersonal dysfunction predicts subsequent financial exploitation vulnerability in a sample of adults over 50: a prospective observational study.

人际功能障碍可预测 50 岁以上成年人样本随后的经济剥削脆弱性：一项前瞻性观察研究。

• DOI: 10.1080/13607863.2022.2076210
• 发表时间: 2023
• 期刊: Aging & mental health
• 影响因子: 3.4
• 作者: Lim,AaronC;Mosqueda,Laura;Nguyen,AnnieL;Mason,TylerB;Weissberger,GaliH;Fenton,Laura;Lichtenberg,Peter;Han,SDuke
• 通讯作者: Han,SDuke

Cognitive and neuroimaging correlates of financial exploitation vulnerability in older adults without dementia: Implications for early detection of Alzheimer's disease.

• DOI: 10.1016/j.neubiorev.2022.104773
• 发表时间: 2022-09
• 期刊: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
• 影响因子: 8.2
• 作者: Fenton, Laura;Weissberger, Gali H.;Boyle, Patricia A.;Mosqueda, Laura;Yassine, Hussein N.;Nguyen, Annie L.;Lim, Aaron C.;Han, S. Duke
• 通讯作者: Han, S. Duke

The Cognitive Correlates of Financial Literacy in Older Adults.

老年人金融素养的认知相关性。

• DOI: 10.1080/07317115.2023.2217190
• 发表时间: 2023
• 期刊: Clinical gerontologist
• 影响因子: 2.8
• 作者: Weissberger,GaliH;Nguyen,AnnieL;Lim,AaronC;Fenton,Laura;Mosqueda,Laura;Han,SDuke
• 通讯作者: Han,SDuke

Increased Financial Altruism is Associated with Alzheimer's Disease Neurocognitive Profile in Older Adults.

• DOI: 10.3233/jad-220187
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Weissberger, Gali H.;Samek, Anya;Mosqueda, Laura;Nguyen, Annie L.;Lim, Aaron C.;Fenton, Laura;Han, S. Duke
• 通讯作者: Han, S. Duke