Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's Disease

项目摘要/摘要 了解老年人的金融剥削是一个重要的公共卫生问题；然而， 为什么一些老年人可能更容易受到欺诈的影响，人们对此知之甚少。为了解决这个问题，我 制定了一项研究计划，专注于了解不同的行为、背景和 影响老年人金融决策和金融剥削脆弱性的神经生物学因素 年龄。这一研究计划利用了南加州大学外部资助的资源和合作 与拉什阿尔茨海默病中心(RADC)合作，共同为学员提供机会 与不同的数据集和研究导师一起工作。影响认知能力的年龄相关性下降 金融决策被认为是老年人欺诈的核心风险因素。阿尔茨海默氏症患者 疾病及相关痴呆症(ADRD)和轻度认知障碍(MCI)被认为风险最大 为了金融剥削。然而，这项研究的大部分都是基于间接证据或轶事证据。 与此相关的是，那些经历过诈骗和欺诈的ADRD患者的认知症状特征是未知的。 神经成像研究已经将特定大脑区域的结构和连通性作为神经生物学 机制；然而，这些机制尚未涉及ADRD患者的具体情况。重要的是，由于各种因素 众所周知，与阿尔茨海默氏症相关的疾病因种族而异，金融诈骗率似乎也不同 根据RACE的说法，理解这些差异在科学上是至关重要的。为了解决这些问题， 本次K24职业发展奖的研究项目建议扩大现有的计划 财务舞弊与健康与退休ADRD关系的研究 研究(HRS)和拉什阿尔茨海默病中心(RADC)队列。HRS被认为是最大的 也是美国最具全国代表性的老龄化研究。2016年，HRS启动了模块2， 它在调查中引入了财务欺诈项目。自2013年以来，RADC一直在收集财务决策 制作和神经成像数据作为其大型、基于社区的神经流行病学的一个组成部分 关于衰老的研究，我一直是其中许多研究的积极合作者。一个拟议的指导团队 由南加州大学和RADC教职员工组成，将为我和我的导师提供指导，专业 HRS和RADC队列中的发展和当前研究方法。最后，因为金融 最近，非痴呆症老年人的脆弱性与阿尔茨海默氏症的风险更高有关 在纵向模型中，我们的次要目标是探索临床前阿尔茨海默氏病的相关性 在一组没有经济剥削风险的当地老年人中，基于血液的疾病生物标记物 认知障碍。这项职业生涯中期奖励将解决ADRD的财务脆弱性问题。

PROJECT SUMMARY/ABSTRACT Understanding financial exploitation among older adults is an important public health issue; however, the reasons why some older adults may be more susceptible to fraud are poorly understood. To address this, I have developed a program of research focused on understanding the diverse behavioral, contextual, and neurobiological factors that impact financial decision making and financial exploitation vulnerability in older age. This program of research leverages extramurally-funded USC-based resources and collaborative endeavors with the Rush Alzheimer’s Disease Center (RADC), which together provide trainees the opportunity to work with diverse datasets and research mentors. Age-related decline in cognitive abilities impacting financial decision making is believed to be a central risk factor for fraud in older age. Those with Alzheimer’s Disease and Related Dementias (ADRD) and Mild Cognitive Impairment (MCI) are believed to be most at risk for financial exploitation. However, most of this research is based either on indirect or anecdotal evidence. Relatedly, cognitive symptom profiles of those with ADRD who experience scam and fraud are unknown. Neuroimaging work has implicated the structure and connectivity of specific brain regions as neurobiological mechanisms; however, these have yet to be implicated in ADRD patients specifically. Importantly, since factors associated with Alzheimer’s Disease are known to differ by race, and rates of financial fraud appear to differ according to race, an understanding of these differences is a scientifically crucial. To address these questions, the research project for this K24 Career Development Award proposes to expand the current program of research by investigating the associations between financial fraud and ADRD in the Health and Retirement Study (HRS) and the Rush Alzheimer’s Disease Center (RADC) cohorts. The HRS is considered the largest and most nationally-representative study of aging in the United States. In 2016, the HRS initiated Module 2, which introduced financial fraud items into the survey. Since 2013, the RADC has collected financial decision making and neuroimaging data as an integrated part of their large, community-based, neuroepidemiologic studies of aging, and I have been an active collaborator on many of these studies. A proposed mentoring team consisting of USC and RADC faculty will provide me and my mentees guidance in mentorship, professional development, and current research approaches in the HRS and RADC cohorts. Finally, because financial vulnerability in non-demented older adults has recently been associated with greater risk for Alzheimer’s Disease in longitudinal models, we secondarily aim to explore the association of preclinical Alzheimer’s Disease blood-based biomarkers with financial exploitation risk in a subset of local older adults without cognitive impairment. This mid-career award will address financial vulnerability considerations in ADRD.