Maternal Stress Resilience During Pregnancy and Offspring Emotion Regulation

怀孕期间母亲的压力恢复能力和后代的情绪调节

• 批准号: 10212561
• 负责人: Irene Tung
• 金额: $ 17.04万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2022-01-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212561
• 关键词: Address; Affect; Affective; Aleurites; Award; Behavior; Biosensing Techniques; Birth; Buffers; Cardiac; Cellular Phone; Childhood; Chronic stress; Data; Data Analytics; Data Collection; Development; Devices; Discrimination; Emotions; Environment; Exposure to; Family; Fetal Development; Foxes; Generations; Goals; Health; In Situ; Individual; Individual Differences; Infant; Institution; Intervention; Life; Link; Literature; Longitudinal Studies; Longitudinal cohort; Low income; Measures; Mental disorders; Mentors; Methodology; Methods; Minority; Modeling; Mothers; Outcome; Parents; Participant; Pathway interactions; Physiological; Physiology; Postpartum Period; Pregnancy; Pregnant Women; Prenatal care; Prevention; Process; Protocols documentation; Psychiatry; Psychopathology; Race; Recording of previous events; Recovery; Regulation; Research; Research Domain Criteria; Resources; Risk; Risk Factors; Role; Sampling; Self Efficacy; Shapes; Social support; Stress; Stressful Event; Testing; Training; United States National Institutes of Health; Universities; Visit; Well in self; Woman; Work; aged; base; career development; emerging adult; emotion regulation; experience; girls; heart rate variability; improved; indexing; infancy; infant outcome; maternal caregiving; maternal stress; middle childhood; offspring; perceived stress; postnatal; pregnant; prenatal; prenatal risk factor; prenatal stress; preventive intervention; programs; prospective; protective factors; psychologic; psychosocial; public health priorities; recruit; resilience; stress resilience; stressor; theories; transmission process; wearable sensor technology

PROJECT SUMMARY/ABSTRACT Evidence shows that maternal stress exposure during pregnancy can have enduring effects on offspring emotion regulation (ER), a transdiagnostic factor underlying the development of psychopathology. Although low-income and minority race women are more likely to experience daily recurring stressors, significant variability exists in the way individuals respond to stressors during pregnancy. Few studies have focused on identifying modifiable, protective factors during pregnancy that explain these individual differences, a critical step to informing preventative interventions. Guided by resilience theories, this study takes a daily-life approach to investigate the prospective association between maternal stress regulation during pregnancy and infant ER. The central hypothesis is that day-to-day fluctuations in prenatal psychosocial resources (social support, self-efficacy) will have a protective influence on daily maternal stress regulation during pregnancy (Aim 1) that, in turn, shapes infant ER outcomes (Aim 2). The study will recruit pregnant participants (N=90) with a history of chronic stress from the Pittsburgh Girls Study (ECHO-PGS; UH3OD023244), a longitudinal cohort of women currently aged 24-27 (71% Black; 79% low-income) who have been assessed annually since childhood. Participants will complete a prenatal lab visit, 10 days of ambulatory data collection, and a postnatal lab visit when their infant is 6-months old. This study will leverage available prenatal and infant data from the ECHO-PGS while adding state-of-the-art ambulatory measures (smartphone, wearable biosensing devices) to measure real-world changes in daily stressful events, stress regulation, and psychosocial resources during pregnancy, in addition to adding new physiological measures of ER in infancy. Dr. Tung, the award candidate, is a developmental psychopathologist with significant experience conducting longitudinal research in the lab- setting from middle childhood through early adulthood. In this K01, the candidate will gain targeted conceptual and methodological training in: (1) ER during infancy, when regulatory processes are emerging and sensitive to stress transmission, (2) ambulatory measures of daily prenatal stress regulation outside the lab setting, and (3) advanced statistical approaches for intensive longitudinal data. Dr. Tung’s mentors (Drs. Hipwell, Low, and Smyth) and consultants (Drs. Fox and Krafty) are ideally suited to guide the candidate’s training given their combined expertise in the fields of prenatal stress, infant affective and physiological regulation, ambulatory assessment, and intensive longitudinal data analytics. As a leading research institution, the University of Pittsburgh Department of Psychiatry is an optimal scientific training environment to meet these career development goals. The proposed K01 is the first step in a larger program of independent research that will focus on prenatal stress and resilience factors underlying transdiagnostic vulnerability to psychopathology. This line of work has the potential to advance the field by elucidating resilience processes during sensitive windows of development to inform early preventative interventions.

项目摘要/摘要 有证据表明，怀孕期间的物质压力暴露会对后代产生持久的影响 情绪调节（ER），这是心理病理发展的基础的转诊因素。虽然 低收入和少数民族种族女性更有可能每天经常出现重复压力，重大压力 在怀孕期间，个人对压力源反应的方式存在变异性。很少有研究重点 在怀孕期间识别可修改的，受保护的因素来解释这些个体差异，这是一个关键的 告知预防干预措施的步骤。在弹性理论的指导下，这项研究需要日常生活 调查怀孕期间物物压力调节与前瞻性关联的方法 婴儿ER。中心假设是产前心理资源的日常波动（社会 支持，自我有效）将对怀孕期间的日常伴生压力受到保护 （目标1）反过来塑造婴儿的结果（AIM 2）。该研究将招募怀孕参与者（n = 90） 匹兹堡女孩研究（Echo-PGS; UH3OD023244）的慢性压力病史，纵向 从那以后每年接受评估的妇女队列目前为24-27岁（71％黑色； 79％低收入） 童年。参与者将完成产前实验室访问，10天的卧床数据收集和产后 当婴儿六个月大时，实验室访问。这项研究将利用可用的产前和婴儿数据 在添加最先进的门诊措施（智能手机，可穿戴生物传感设备）的同时，Echo-PG 测量每日压力事件，压力调节和心理社会资源的现实世界变化 怀孕，除了增加婴儿期ER的新物理措施外。 Tung博士，颁奖者， 是一名发育心理病理学家，在实验室中进行纵向研究具有丰富的经验 从童年到成年初期。在此K01中，候选人将获得针对性的概念 和方法学培训：（1）在开始时期的急诊期，调节过程正在出现和敏感 为了压力传播，（2）实验室设置以外的日常产前应力调节的门诊措施， （3）密集纵向数据的高级统计方法。 Tung博士的导师（Hipwell博士，Low和 SMYTH）和顾问（Fox和Krafty博士）非常适合指导候选人的培训 在产前压力，婴儿情感和身体调节，卧床领域的联合专业知识 作为领先的研究机构，大学 匹兹堡精神病学系是满足这些职业的最佳科学培训环境 发展目标。拟议的K01是较大的独立研究计划的第一步，该计划将 专注于转诊的产前压力和弹性因素，对精神病理学的脆弱性。 这项工作有可能通过在敏感的过程中阐明弹性过程来推进该领域 开发窗口，以告知早期预防性干预措施。