Maternal Stress Resilience During Pregnancy and Offspring Emotion Regulation

怀孕期间母亲的压力恢复能力和后代的情绪调节

• 批准号: 10598135
• 负责人: Irene Tung
• 金额: $ 16.63万
• 依托单位: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598135
• 关键词: Address; Affect; Affective; Aleurites; Award; Behavior; Biosensing Techniques; Birth; Black race; Buffers; Cardiac; Cellular Phone; Childhood; Chronic stress; Data; Data Analytics; Data Collection; Development; Devices; Diagnostic; Diagnostic Factor; Discrimination; Emotions; Environment; Exposure to; Family; Fetal Development; Generations; Goals; Health; In Situ; Individual; Individual Differences; Infant; Institution; Intervention; Life; Link; Literature; Longitudinal Studies; Longitudinal cohort; Low income; Measures; Mental disorders; Mentors; Methodology; Methods; Modeling; Mothers; Outcome; Parents; Participant; Pathway interactions; Physiological; Physiology; Postpartum Period; Pregnancy; Pregnant Women; Prenatal care; Prevention; Process; Protocols documentation; Psychiatry; Psychopathology; Recording of previous events; Recovery; Recurrence; Regulation; Research; Research Domain Criteria; Resources; Risk; Risk Factors; Role; Sampling; Self Efficacy; Shapes; Social support; Stress; Stressful Event; Testing; Training; United States National Institutes of Health; Universities; Visit; Well in self; Woman; Work; aged; career development; emerging adult; emotion regulation; experience; girls; heart rate variability; improved; indexing; infancy; infant outcome; maternal caregiving; maternal stress; middle childhood; offspring; perceived stress; postnatal; pregnant; prenatal; prenatal risk factor; prenatal stress; preventive intervention; programs; prospective; protective factors; psychologic; psychosocial resources; public health priorities; racial minority; recruit; resilience; resilience factor; stress resilience; stressor; theories; transmission process; wearable sensor technology

PROJECT SUMMARY/ABSTRACT Evidence shows that maternal stress exposure during pregnancy can have enduring effects on offspring emotion regulation (ER), a transdiagnostic factor underlying the development of psychopathology. Although low-income and minority race women are more likely to experience daily recurring stressors, significant variability exists in the way individuals respond to stressors during pregnancy. Few studies have focused on identifying modifiable, protective factors during pregnancy that explain these individual differences, a critical step to informing preventative interventions. Guided by resilience theories, this study takes a daily-life approach to investigate the prospective association between maternal stress regulation during pregnancy and infant ER. The central hypothesis is that day-to-day fluctuations in prenatal psychosocial resources (social support, self-efficacy) will have a protective influence on daily maternal stress regulation during pregnancy (Aim 1) that, in turn, shapes infant ER outcomes (Aim 2). The study will recruit pregnant participants (N=90) with a history of chronic stress from the Pittsburgh Girls Study (ECHO-PGS; UH3OD023244), a longitudinal cohort of women currently aged 24-27 (71% Black; 79% low-income) who have been assessed annually since childhood. Participants will complete a prenatal lab visit, 10 days of ambulatory data collection, and a postnatal lab visit when their infant is 6-months old. This study will leverage available prenatal and infant data from the ECHO-PGS while adding state-of-the-art ambulatory measures (smartphone, wearable biosensing devices) to measure real-world changes in daily stressful events, stress regulation, and psychosocial resources during pregnancy, in addition to adding new physiological measures of ER in infancy. Dr. Tung, the award candidate, is a developmental psychopathologist with significant experience conducting longitudinal research in the lab- setting from middle childhood through early adulthood. In this K01, the candidate will gain targeted conceptual and methodological training in: (1) ER during infancy, when regulatory processes are emerging and sensitive to stress transmission, (2) ambulatory measures of daily prenatal stress regulation outside the lab setting, and (3) advanced statistical approaches for intensive longitudinal data. Dr. Tung’s mentors (Drs. Hipwell, Low, and Smyth) and consultants (Drs. Fox and Krafty) are ideally suited to guide the candidate’s training given their combined expertise in the fields of prenatal stress, infant affective and physiological regulation, ambulatory assessment, and intensive longitudinal data analytics. As a leading research institution, the University of Pittsburgh Department of Psychiatry is an optimal scientific training environment to meet these career development goals. The proposed K01 is the first step in a larger program of independent research that will focus on prenatal stress and resilience factors underlying transdiagnostic vulnerability to psychopathology. This line of work has the potential to advance the field by elucidating resilience processes during sensitive windows of development to inform early preventative interventions.

项目概要/摘要 有证据表明，母亲在怀孕期间承受的压力会对后代产生持久影响 情绪调节（ER），是精神病理学发展的跨诊断因素。虽然 低收入和少数族裔女性更有可能经历日常反复出现的压力源，显着 怀孕期间个体对压力源的反应方式存在差异。很少有研究关注 确定怀孕期间可改变的保护性因素来解释这些个体差异，这是一个关键 告知预防性干预措施的步骤。这项研究以复原力理论为指导，以日常生活为背景 方法研究妊娠期间母亲压力调节与 婴儿急诊室。中心假设是产前心理社会资源（社会心理资源）的日常波动 支持、自我效能）将对孕期日常母亲压力调节产生保护性影响 （目标 1），进而影响婴儿 ER 结局（目标 2）。该研究将招募怀孕参与者（N=90） 来自匹兹堡女孩研究（ECHO-PGS；UH3OD023244）的慢性压力史，一项纵向研究 目前年龄为 24-27 岁的女性群体（71% 是黑人；79% 是低收入），自此以来每年接受一次评估 童年。参与者将完成产前实验室访问、10 天的动态数据收集以及产后检查 当他们的婴儿 6 个月大时参观实验室。这项研究将利用现有的产前和婴儿数据 ECHO-PGS 同时添加最先进的动态测量（智能手机、可穿戴生物传感设备） 衡量日常压力事件、压力调节和社会心理资源的现实变化 怀孕期间，除了在婴儿期添加新的 ER 生理测量之外。获奖候选人董博士， 是一位发展精神病理学家，拥有在实验室进行纵向研究的丰富经验- 设定从童年中期到成年早期。在这个K01中，考生将获得有针对性的概念 和方法培训：（1）婴儿期的急诊室，此时监管过程正在兴起且敏感 压力传递，(2) 在实验室环境之外进行日常产前压力调节的动态测量，以及 (3)密集纵向数据的先进统计方法。董博士的导师（Hipwell 博士、Low 博士和 Smyth）和顾问（Fox 博士和 Krafty 博士）非常适合指导候选人的培训，因为他们的能力 结合产前应激、婴儿情感和生理调节、动态等领域的专业知识 评估和密集的纵向数据分析。作为领先的研究机构，英国大学 匹兹堡精神病学系是满足这些职业需求的最佳科学培训环境 发展目标。拟议的 K01 是更大的独立研究计划的第一步，该计划将 重点关注跨诊断易受精神病理学影响的产前压力和复原力因素。 这一系列工作有可能通过阐明敏感时期的恢复过程来推动该领域的发展。 发展窗口期为早期预防性干预措施提供信息。