CSHL 2020 Systems Biology Conference: Global Regulation of Gene Expression

冷泉港会议 系统生物学：基因表达的全球调控 2020-2024 摘要 细胞如何控制其基因组的表达是生物学中的一个基本问题。怎么了？ 基因表达的协调调节受到细胞和组织变化的影响 环境是另一个基本问题。自从发现基因被编码以来 在组成双链DNA螺旋的核苷酸序列中，有 对这些问题的持续调查。制作成绩单的核机器 以及用于控制基因表达的多种类型的DNA序列 被发现了。尽管作出了这些努力，但与全球经济一体化有关的许多根本问题 基因表达的调控仍未解决。例如，转录调控 人类基因组中大多数基因的序列和调控蛋白仍然很差。 已定义。我们还不能高精度地预测人类基因的表达模式 其周围调控DNA的序列或附近表观遗传标记的模式，或如何 这些都受到环境变化的影响。在大多数情况下，我们也不能使理性 DNA的改变，导致特定的、预先定义的表达变化。很明显， 实验生物学家和计算生物学家之间的有效合作将需要 来处理基因调控的复杂问题。因此，我们提议主办会议 促进现有思想和专业知识的跨学科自由交流。人们希望， 这些会议将为建立新的合作提供机制，并 讨论新的实验和计算方法的论坛。 这项提案寻求国家卫生研究院(NHGRI)的资金，主要是为了支持积极的 青年科学家(研究生、博士后研究员和新教师)参与 继续举行一系列关于系统生物学的科学会议，这些会议以前曾在 冷泉港实验室(CSHL)和波多黎各。2020-2024年的会议将是 由CSHL在CSHL校园内管理。这些会议旨在促进交叉- 实验者和计算学家之间的思想和专业知识的学科交流 生物学家对复杂转录网络的组织和控制感兴趣 真核生物。拟议的会议将集中讨论几个关键主题：转录监管 网络；顺式调控逻辑；染色质与表观遗传学；转录后调控； 变异与进化；新兴技术；发育网络与细胞反应。 演讲将由一群杰出的特邀演讲者以及 演讲者从提交的摘要中选出。选定的演讲者将包括研究生， 博士后研究员和初级教员，旨在最大限度地纳入年轻研究人员。的 特别重要的是两个海报会议，在那里许多参与者可以展示他们的作品 在有利于非正式讨论的气氛中。这次会议将是中等规模和 我们预计将有250-300人参加，其中绝大多数人将展示海报 也不会说话。这项提案寻求资金，以支持早期职业调查人员参与 这个重要的会议。

Cold Spring Harbor Conference Systems Biology: Global Regulation of Gene Expression 2020 - 2024 ABSTRACT How cells control the expression of their genomes is a fundamental problem in biology. How the coordinate regulation of gene expression is affected by changes in the cellular and organismal environment is another fundamental question. Ever since the discovery that genes are encoded in the sequence of nucleotides that comprise the double strand DNA helix, there have been continuous investigations into these problems. The nuclear machineries that make transcripts as well as the many types of DNA sequences that serve to control gene expression have been discovered. Despite these efforts, many fundamental issues associated with the global regulation of gene expression remain unresolved. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined. We cannot yet predict a human gene's expression pattern with high accuracy from the sequence of its surrounding regulatory DNA or the pattern of nearby epigenetic marks, or how these are affected by environmental change. Nor, in the majority of cases, can we make rational alterations to the DNA that result in specific, predefined changes in expression. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problems of gene regulation. Thus we propose to host meetings that foster the free cross-disciplinary exchange of existing ideas and expertise. It is hoped that these meetings will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. This proposal seeks National Institutes of Health (NHGRI) funding primarily to support the active participation of young scientists (graduate students, postdoctoral fellows and new faculty) in a continuing series of scientific meetings on systems biology, which have previously been held at Cold Spring Harbor Laboratory (CSHL) and in Puerto Rico. The 2020-2024 conferences will be managed by CSHL on the CSHL campus. These meetings are intended to foster cross- disciplinary exchange of ideas and expertise between experimentalists and computational biologists interested in the organization and control of complex transcription networks in eukaryotes. The proposed meeting will focus on several key themes: Transcriptional Regulatory Networks; Cis-Regulatory Logic; Chromatin & Epigenetics; Post-transcriptional Regulation; Variation & Evolution; Emerging Technologies; Developmental Networks & Cellular Responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250-300 people to attend, the vast majority of whom will be presenting a poster or talk. This proposal seeks funding to support the participation of early career investigators in this important meeting.