CSHL 2020 Systems Biology Conference: Global Regulation of Gene Expression

冷泉港会议 系统生物学：基因表达的全局调控 2020 - 2024年 摘要 细胞如何控制其基因组的表达是生物学中的一个基本问题。如何 基因表达的协调调节受到细胞和生物体中的变化的影响， 环境是另一个基本问题。自从发现基因编码 在构成双链DNA螺旋的核苷酸序列中， 对这些问题的持续调查。制作转录本的核机器 以及用于控制基因表达的许多类型的DNA序列， 发现了尽管作出了这些努力，但与全球经济有关的许多基本问题仍然存在。 基因表达的调控仍然没有得到解决。例如，转录调节因子 人类基因组中大多数基因的序列和调节蛋白仍然很差， 定义了我们还不能从基因组中高精度地预测人类基因的表达模式。 它周围的调控DNA序列或附近的表观遗传标记的模式，或者如何 这些都受到环境变化的影响。在大多数情况下，我们也不能使 DNA的改变，导致特定的，预定义的表达变化。很明显 需要实验生物学家和计算生物学家之间的有效合作， 来处理基因调控的复杂问题。因此，我们提议主办会议， 促进现有思想和专业知识的跨学科自由交流。人们希望 这些会议将为建立新的合作提供一个机制， 讨论新的实验和计算方法的论坛。 该提案寻求国立卫生研究院（NHGRI）的资助，主要用于支持活跃的 青年科学家（研究生、博士后研究员和新教员）参加 继续举行一系列关于系统生物学的科学会议， 冷泉港实验室（CSHL）和波多黎各。2020 - 2024年会议将在 由CSHL在CSHL校园内管理。这些会议旨在促进跨- 实验学家和计算科学家之间的思想和专业知识的学科交流 生物学家对复杂转录网络的组织和控制感兴趣， 真核生物拟议的会议将集中讨论几个关键主题：转录调控 网络;顺式调控逻辑;染色质与表观遗传学;转录后调控; 变异与进化;新兴技术;发育网络与细胞反应。 一组杰出的特邀演讲者将作口头介绍， 从提交的摘要中选出发言者。选定的演讲者将包括研究生， 博士后研究员和初级教师，旨在最大限度地纳入年轻的研究人员。的 特别重要的是两个海报会议，许多与会者可以介绍他们的工作 在有利于非正式讨论气氛中进行。会议规模适中， 我们预计大约有250 - 300人参加，其中绝大多数人将展示海报 也不说话该提案寻求资金，以支持早期职业调查员参与 这一重要会议。

Cold Spring Harbor Conference Systems Biology: Global Regulation of Gene Expression 2020 - 2024 ABSTRACT How cells control the expression of their genomes is a fundamental problem in biology. How the coordinate regulation of gene expression is affected by changes in the cellular and organismal environment is another fundamental question. Ever since the discovery that genes are encoded in the sequence of nucleotides that comprise the double strand DNA helix, there have been continuous investigations into these problems. The nuclear machineries that make transcripts as well as the many types of DNA sequences that serve to control gene expression have been discovered. Despite these efforts, many fundamental issues associated with the global regulation of gene expression remain unresolved. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined. We cannot yet predict a human gene's expression pattern with high accuracy from the sequence of its surrounding regulatory DNA or the pattern of nearby epigenetic marks, or how these are affected by environmental change. Nor, in the majority of cases, can we make rational alterations to the DNA that result in specific, predefined changes in expression. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problems of gene regulation. Thus we propose to host meetings that foster the free cross-disciplinary exchange of existing ideas and expertise. It is hoped that these meetings will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. This proposal seeks National Institutes of Health (NHGRI) funding primarily to support the active participation of young scientists (graduate students, postdoctoral fellows and new faculty) in a continuing series of scientific meetings on systems biology, which have previously been held at Cold Spring Harbor Laboratory (CSHL) and in Puerto Rico. The 2020-2024 conferences will be managed by CSHL on the CSHL campus. These meetings are intended to foster cross- disciplinary exchange of ideas and expertise between experimentalists and computational biologists interested in the organization and control of complex transcription networks in eukaryotes. The proposed meeting will focus on several key themes: Transcriptional Regulatory Networks; Cis-Regulatory Logic; Chromatin & Epigenetics; Post-transcriptional Regulation; Variation & Evolution; Emerging Technologies; Developmental Networks & Cellular Responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250-300 people to attend, the vast majority of whom will be presenting a poster or talk. This proposal seeks funding to support the participation of early career investigators in this important meeting.