Training Interdisciplinary Pharmacology Scientists (TIPS)

培训跨学科药理学科学家（TIPS）

• 批准号: 10398794
• 负责人: Carmen W. Dessauer
• 金额: $ 23.56万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398794
• 关键词: Pharmacology; Scientist; Training

PROJECT SUMMARY / ABSTRACT Training Interdisciplinary Pharmacology Scientists (TIPS) will train predoctoral students to address critical issues in drug development, by providing them the tools and knowledge to navigate the ever- changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This integrated T32 program is designed to create leaders in the broadly defined field of Pharmacological Sciences. TIPS will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, and an understanding of regulatory issues involved in advancing candidate therapeutics to clinical application. Through the participation of 3 premier and neighboring biomedical research institutions and their graduate schools (University of Texas Health Science Center at Houston, Baylor College of Medicine, and Rice University), TIPS will provide interdisciplinary training, career development activities and industry shadowships that will prepare students to advance biomedical research through successful careers in academia, government and regulatory agencies, and industry. Program leadership includes the program director and co-director and a steering committee of representatives from the participating graduate programs, along with an external advisory committee of diverse experts. TIPS program requirements and benefits will include co-mentoring from two faculty in a collaborative research project; specific didactic and elective courses (available to TIPS trainees at all participating schools); monthly trainee meetings to build a unified cohort; a wide variety of career development activities, and required training in the responsible conduct of research and rigor and reproducibility. Mentors will include 31 faculty members at 3 institutions, working in 14 graduate programs, who have training and research expertise in drug/compound screening, pharmacology, computation, medicinal chemistry, structural biology, systems biology, biochemistry, genetics, and molecular and cellular biology. All participating departments recruit nationwide, especially for students of diverse backgrounds who are under-represented in the biomedical sciences, including individuals with disabilities, from disadvantaged backgrounds, and from under-represented racial and ethnic groups. This provides a large, diverse pool of predoctoral students from a variety of backgrounds for our 5 requested slots. Students will apply to TIPS after joining a lab near the end of their first year or during their second year of graduate school, and if selected through a holistic application process, will receive two years of support. Reappointment to a second year will be contingent on a thorough oral and written review of trainee research progress and completion of program requirements. TIPS will complement the degree requirements of a trainee’s home institution, causing no delay in degree completion. The interdisciplinary skills emphasized by this program will produce pharmacology scientists well positioned to advance biomedical research and to address the complexity of drug development.

项目摘要/摘要 培训跨学科药理学科学家(TIPS)将培训博士后学生解决 药物开发中的关键问题，通过为他们提供工具和知识来驾驭 不断变化的、跨学科的格局，构成了当今的基础、转化性和临床研究。这 综合T32计划旨在培养广泛定义的药理科学领域的领导者。 TIPS将提供药物开发方面的跨学科培训，包括筛选、计算、医学 与目标发现和验证相关的化学和结构生物学，以及对 将候选疗法推向临床所涉及的监管问题。通过参与 3所主要和邻近的生物医学研究机构及其研究生院(德克萨斯大学 休斯顿健康科学中心、贝勒医学院和莱斯大学)，TIPS将提供 跨学科培训、职业发展活动和行业影子，将使学生做好准备 通过在学术界、政府和监管机构的成功职业生涯推动生物医学研究， 和工业。计划领导包括计划主任和联合主任以及一个指导委员会 来自参与研究生项目的代表，以及不同的外部咨询委员会 专家。TIPS计划要求和福利将包括来自两个教职员工的共同指导 研究项目；具体的授课和选修课程(向所有参与学校的TIP学员提供)； 每月召开实习生会议，以建立统一的队列；开展各种各样的职业发展活动，并要求 负责任地进行研究以及严谨和可重复性方面的培训。导师将包括31名教职员工 3个机构的成员，在14个研究生项目中工作，他们在以下方面具有培训和研究专长 药物/化合物筛选、药理学、计算、药物化学、结构生物学、系统学 生物学、生物化学、遗传学、分子和细胞生物学。所有参与部门均会招募 全国范围内，特别是对于不同背景的学生，他们在生物医学领域的代表性不足 科学，包括残疾人、弱势背景和代表性不足的人 种族和民族群体。这为来自不同领域的博士前学生提供了一个庞大的、多样化的人才库 我们的5个要求插槽的背景。学生将在第一次实验结束时加入实验室后申请TIPS 一年或研究生二年级期间，如果通过整体申请程序被选中，将 获得两年的支持。第二年的重新任命将取决于彻底的口头和书面 审核受训人员的研究进展和完成项目要求。提示将是对 学员所在院校的学位要求，不会导致学位完成延迟。这个 该项目强调的跨学科技能将使药理学科学家处于有利地位 推进生物医学研究，解决药物开发的复杂性。