Training Interdisciplinary Pharmacology Scientists (TIPS)

培训跨学科药理学科学家（TIPS）

• 批准号: 10398794
• 负责人: Carmen W. Dessauer
• 金额: $ 23.56万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398794
• 关键词: Pharmacology; Scientist; Training

PROJECT SUMMARY / ABSTRACT Training Interdisciplinary Pharmacology Scientists (TIPS) will train predoctoral students to address critical issues in drug development, by providing them the tools and knowledge to navigate the ever- changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This integrated T32 program is designed to create leaders in the broadly defined field of Pharmacological Sciences. TIPS will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, and an understanding of regulatory issues involved in advancing candidate therapeutics to clinical application. Through the participation of 3 premier and neighboring biomedical research institutions and their graduate schools (University of Texas Health Science Center at Houston, Baylor College of Medicine, and Rice University), TIPS will provide interdisciplinary training, career development activities and industry shadowships that will prepare students to advance biomedical research through successful careers in academia, government and regulatory agencies, and industry. Program leadership includes the program director and co-director and a steering committee of representatives from the participating graduate programs, along with an external advisory committee of diverse experts. TIPS program requirements and benefits will include co-mentoring from two faculty in a collaborative research project; specific didactic and elective courses (available to TIPS trainees at all participating schools); monthly trainee meetings to build a unified cohort; a wide variety of career development activities, and required training in the responsible conduct of research and rigor and reproducibility. Mentors will include 31 faculty members at 3 institutions, working in 14 graduate programs, who have training and research expertise in drug/compound screening, pharmacology, computation, medicinal chemistry, structural biology, systems biology, biochemistry, genetics, and molecular and cellular biology. All participating departments recruit nationwide, especially for students of diverse backgrounds who are under-represented in the biomedical sciences, including individuals with disabilities, from disadvantaged backgrounds, and from under-represented racial and ethnic groups. This provides a large, diverse pool of predoctoral students from a variety of backgrounds for our 5 requested slots. Students will apply to TIPS after joining a lab near the end of their first year or during their second year of graduate school, and if selected through a holistic application process, will receive two years of support. Reappointment to a second year will be contingent on a thorough oral and written review of trainee research progress and completion of program requirements. TIPS will complement the degree requirements of a trainee’s home institution, causing no delay in degree completion. The interdisciplinary skills emphasized by this program will produce pharmacology scientists well positioned to advance biomedical research and to address the complexity of drug development.

项目摘要 /摘要 培训跨学科药理学科学家（技巧）将培训术前学生以解决 药物开发中的关键问题，通过为他们提供工具和知识来导航不断的 构成当今基本，翻译和临床研究的变化，跨学科的景观。这 综合T32程序旨在在药理学广泛定义的领域创建领导者。 提示将提供药物开发的跨学科培训，包括筛查，计算，医学 化学和与目标发现和验证相关的结构生物学以及对 将候选疗法推进临床应用中涉及的监管问题。通过参与 3个主要和邻近的生物医学研究机构及其研究生院（德克萨斯大学 休斯顿的健康科学中心，贝勒医学院和赖斯大学），提示将提供 跨学科的培训，职业发展活动和行业阴影，这将使学生做好准备 通过学术界，政府和监管机构的成功职业发展生物医学研究， 和行业。计划领导包括计划主任兼联合主任，以及指导委员会的指导委员会 参与研究生课程的代表以及潜水员的外部咨询委员会 专家。提示计划的要求和收益将包括合作的两位教师的同学 研究项目；特定的教学课程和选修课程（所有参与学校的tip训练者都可以接受）； 每月的实习生会议建立统一的队列；各种各样的职业发展活动，需要 负责研究，严格和可重复性的培训。导师将包括31位教师 3个机构的成员，在14个研究生课程中工作，他们拥有培训和研究专业知识 药物/化合物筛查，药物，计算，医学化学，结构生物学，系统 生物学，生物化学，遗传学以及分子和细胞生物学。所有参与部门招募 在全国范围 科学，包括弱势背景的残疾人，以及代表不足的科学 种族和种族。这提供了来自各种各样的大型潜水员库。 我们要求的5个插槽的背景。学生将在第一次结束后加入实验室后申请提示 年学年或研究生第二年，如果通过整体申请过程进行选择，将 获得两年的支持。重新任命第二年将取决于彻底的口头和书面 审查学员研究的进度和计划要求的完成。提示将完成 学员家庭机构的学位要求，不会延迟完成学位。这 该计划强调的跨学科技能将产生适合的药物科学 提前生物医学研究并解决药物开发的复杂性。