Training Interdisciplinary Pharmacology Scientists

培养跨学科药理学科学家

• 批准号: 9150908
• 负责人: Carmen W. Dessauer
• 金额: $ 20.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150908
• 关键词: Pharmacology; Scientist; Training

PROJECT SUMMARY / ABSTRACT Training Interdisciplinary Pharmacology Scientists (TIPS) will train predoctoral students to address critical issues in drug development, by providing them the tools and knowledge to navigate the ever- changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This T32 program is designed to create leaders in the broadly defined field of Pharmacological Sciences. TIPS will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, while exploring how to maximize therapeutic benefit, minimize toxicity and implement precision medicine. Through the participation of 3 premier and neighboring biomedical research institutions and their graduate schools (University of Texas Health Science Center at Houston, Baylor College of Medicine, and Rice University), TIPS will provide interdisciplinary training, career development activities and industry shadowships that will prepare students to advance biomedical research through successful careers in academia, government and regulatory agencies, and industry. Program leadership includes the program director and co-director and a steering committee of representatives from the participating graduate schools, with assistance from an advisory committee of diverse experts. TIPS program requirements and benefits will include co-mentoring from two faculty in a collaborative research project; specific didactic and elective courses (available to TIPS trainees at all participating graduate schools); monthly trainee meetings to build a unified cohort; career development activities, and required training in the responsible conduct of research. Mentors will include 26 faculty members at 3 institutions, working in 9 different departments and two interdepartmental graduate programs, who have training and research expertise in drug/compound screening, pharmacology, computation, medicinal chemistry, structural biology, systems biology, biochemistry, genetics, and molecular and cellular biology. All participating departments recruit nationwide, especially for under-represented minority students and students with disabilities. This provides a large, diverse pool of predoctoral students from a variety of backgrounds for our 5 requested slots. Students will apply to TIPS after joining a lab near the end of their first year or during their second year of graduate school, and if selected through a competitive application process, will receive two years of support. Reappointment to a second year will be contingent on a thorough oral and written review of trainee research progress and completion of program requirements. TIPS will complement the degree requirements of a trainee’s home institution, causing no delay in degree completion. The interdisciplinary skills emphasized by this program will produce pharmacology scientists well positioned to advance biomedical research and to address the complexity of drug development.

项目摘要/摘要 培训跨学科药理学科学家(TIPS)将培训博士后学生解决 药物开发中的关键问题，通过为他们提供工具和知识来驾驭 不断变化的、跨学科的格局，构成了当今的基础、转化性和临床研究。这款T32 该计划旨在培养广泛定义的药理科学领域的领军人物。小费将 提供药物开发方面的跨学科培训，包括筛选、计算、药物化学、 以及与靶标发现和验证相关的结构生物学，同时探索如何最大限度地发挥治疗作用 受益，最大限度地减少毒性，实施精准医疗。通过3位总理和 邻近的生物医学研究机构及其研究生院(德克萨斯大学健康科学 休斯顿中心、贝勒医学院和莱斯大学)，TIPS将提供跨学科培训， 职业发展活动和行业影子，将为学生发展生物医学做好准备 通过在学术界、政府和监管机构以及行业的成功职业生涯进行研究。计划 领导层包括项目主任和联席主任，以及由来自 在一个由不同专家组成的咨询委员会的协助下，参加研究生院。TIPS计划 要求和福利将包括在一个合作研究项目中来自两个教员的共同指导； 具体的授课和选修课程(在所有参与的研究生院向TIP学员提供)；每月 实习生会议，以建立统一的队列；职业发展活动，以及所需的 负责任的研究行为。导师将包括3个机构的26名教职员工，在9个机构工作 不同的部门和两个跨部门的研究生课程，他们有培训和研究专长 药物/化合物筛选、药理学、计算、药物化学、结构生物学、系统 生物学、生物化学、遗传学、分子和细胞生物学。所有参与部门均会招募 在全国范围内，特别是针对代表性不足的少数民族学生和残疾学生。这提供了一种 在我们的5个申请名额中，有大量来自不同背景的博士前学生。学生 将在第一年接近尾声或在研究生第二年进入实验室后申请TIPS 学校，如果通过竞争申请程序被选中，将获得两年的支持。 第二年的重新任命将取决于对学员研究的全面口头和书面审查。 计划要求的进度和完成情况。TIPS将补充学位要求 学员的母校，不会导致学位完成的延迟。所强调的跨学科技能 该计划将培养出能够促进生物医学研究的药理学科学家，并 解决药物开发的复杂性。