Training Interdisciplinary Pharmacology Scientists

培养跨学科药理学科学家

• 批准号: 9150908
• 负责人: Carmen W. Dessauer
• 金额: $ 20.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150908
• 关键词: Pharmacology; Scientist; Training

PROJECT SUMMARY / ABSTRACT Training Interdisciplinary Pharmacology Scientists (TIPS) will train predoctoral students to address critical issues in drug development, by providing them the tools and knowledge to navigate the ever- changing, interdisciplinary landscape that makes up today’s basic, translational, and clinical research. This T32 program is designed to create leaders in the broadly defined field of Pharmacological Sciences. TIPS will provide interdisciplinary training in drug development including screening, computation, medicinal chemistry, and structural biology relevant to target discovery and validation, while exploring how to maximize therapeutic benefit, minimize toxicity and implement precision medicine. Through the participation of 3 premier and neighboring biomedical research institutions and their graduate schools (University of Texas Health Science Center at Houston, Baylor College of Medicine, and Rice University), TIPS will provide interdisciplinary training, career development activities and industry shadowships that will prepare students to advance biomedical research through successful careers in academia, government and regulatory agencies, and industry. Program leadership includes the program director and co-director and a steering committee of representatives from the participating graduate schools, with assistance from an advisory committee of diverse experts. TIPS program requirements and benefits will include co-mentoring from two faculty in a collaborative research project; specific didactic and elective courses (available to TIPS trainees at all participating graduate schools); monthly trainee meetings to build a unified cohort; career development activities, and required training in the responsible conduct of research. Mentors will include 26 faculty members at 3 institutions, working in 9 different departments and two interdepartmental graduate programs, who have training and research expertise in drug/compound screening, pharmacology, computation, medicinal chemistry, structural biology, systems biology, biochemistry, genetics, and molecular and cellular biology. All participating departments recruit nationwide, especially for under-represented minority students and students with disabilities. This provides a large, diverse pool of predoctoral students from a variety of backgrounds for our 5 requested slots. Students will apply to TIPS after joining a lab near the end of their first year or during their second year of graduate school, and if selected through a competitive application process, will receive two years of support. Reappointment to a second year will be contingent on a thorough oral and written review of trainee research progress and completion of program requirements. TIPS will complement the degree requirements of a trainee’s home institution, causing no delay in degree completion. The interdisciplinary skills emphasized by this program will produce pharmacology scientists well positioned to advance biomedical research and to address the complexity of drug development.

项目总结/摘要 培训跨学科药理学科学家（TIPS）将培训博士前学生，以解决 药物开发中的关键问题，为他们提供工具和知识来应对不断变化的问题 不断变化的跨学科景观，构成了今天的基础，转化和临床研究。T32 该计划旨在培养广泛定义的药理学领域的领导者。提示将 提供药物开发的跨学科培训，包括筛选，计算，药物化学， 与靶点发现和验证相关的结构生物学，同时探索如何最大限度地提高治疗效果， 受益，最大限度地减少毒性，并实施精准医疗。通过参加3总理和 邻近的生物医学研究机构及其研究生院（德克萨斯大学健康科学 中心在休斯顿，贝勒医学院和赖斯大学），TIPS将提供跨学科的培训， 职业发展活动和行业影子，这将使学生准备推进生物医学 通过在学术界，政府和监管机构以及工业界的成功职业生涯进行研究。程序 领导层包括项目主任和联合主任以及由来自 参与的研究生院，由不同的专家咨询委员会的援助。TIPS程序 要求和好处将包括从两个教师在合作研究项目的共同指导; 具体的教学和选修课程（向所有参与研究生院的TIPS学员提供）;每月 为建立一个统一的队伍而举行的受训人员会议;职业发展活动， 负责任地进行研究。导师将包括来自3个机构的26名教员， 不同的部门和两个跨部门的研究生课程，谁拥有培训和研究专业知识 在药物/化合物筛选，药理学，计算，药物化学，结构生物学，系统 生物学、生物化学、遗传学以及分子和细胞生物学。所有参与部门招募 在全国范围内，特别是对代表性不足的少数民族学生和残疾学生。这提供了 来自各种背景的博士前学生的大型，多样化的游泳池为我们的5个要求的插槽。学生 将在第一年年底或研究生第二年加入实验室后申请TIPS 学校，如果通过竞争性的申请过程中选择，将获得两年的支持。 第二年的重新任命将取决于对受训人员的研究进行彻底的口头和书面审查 进度和完成计划要求。TIPS将补充学位要求的一个 学员的家乡机构，不造成学位完成的延误。强调的跨学科技能 该计划将培养药理学科学家，以推进生物医学研究， 解决药物开发的复杂性。