Developing a computational electroencephalogram (EEG) paradigm to study prediction error in anorexia nervosa
开发计算脑电图 (EEG) 范式来研究神经性厌食症的预测误差
基本信息
- 批准号:10224812
- 负责人:
- 金额:$ 23.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAffectAgeAmerican Psychiatric AssociationAnorexia NervosaAnteriorBayesian ModelingBiological MarkersBody Weight decreasedBrainBrain imagingCharacteristicsChronic DiseaseComputer ModelsCorpus striatum structureDataDevelopmentDiseaseDopamineEatingEating DisordersElectroencephalogramElectroencephalographyEvent-Related PotentialsExploratory/Developmental GrantFeedbackFemaleFemale AdolescentsFoodFrightFunctional Magnetic Resonance ImagingFunctional disorderFutureIndividualInsula of ReilLearningMRI ScansMagnetic ResonanceMeasuresMetalsMethodsModelingNeurobiologyNeuronsNeurotransmittersParticipantPathway interactionsPatternPharmacologyPredictive ValueProtocols documentationPsychological reinforcementResearchRewardsRoleSignal TransductionStimulusStructureSucroseTaste PerceptionTechniquesTestingTimeTreatment outcomeVentral StriatumWeight Gainbasebrain volumeclassical conditioningcomparison groupcostdopamine systemfeasibility testingfood restrictionindependent component analysismortalityneuroimagingrecruitresponsereward circuitryreward processingsevere psychiatric disordersource localizationtaste stimuli
项目摘要
Abstract
Adolescent anorexia nervosa (AN) is an eating disorder associated with intense fear of weight gain, food
refusal, and severe weight loss. AN is the third most common chronic illness among adolescent females with a
mortality rate 12 times higher than expected for females 15-24 years old. Little is known about biomarkers in
adolescent AN. Neuroimaging studies using techniques such as functional magnetic resonance imaging (fMRI)
have repeatedly suggested altered reward processing in AN including studies using the dopamine associated
prediction error (PE) model. The brain PE response is elicited during unexpected receipt or omission of reward
stimuli and thought to reflect the functionality of brain dopamine circuits. This is an important research direction
as the dopamine system can be manipulated pharmacologically. Ill adolescent or adult individuals with AN
showed elevated PE response to repeated sucrose taste receipt in insula and striatum. PE was also inversely
related to weight gain in treatment. Thus, PE brain response promises to be an important biological marker for
adolescent AN with predictive value for treatment outcome. However, functional brain imaging is costly,
prohibitive for instance for individuals with braces or other metal in their body and only available at certain
centers. In order to study PE in AN in larger scale studies, a more practical approach and method need to be
developed. In this application, we will use the exploratory/developmental R21 mechanism to develop a study
protocol using electroencephalography (EEG) to study PE signals in adolescent AN. Recent studies in healthy
individuals support that this is a valid approach.
In Aim 1. we test the feasibility of adapting a computational taste PE reinforcement learning paradigm from
fMRI to EEG in adolescents with AN and healthy controls. We expect that we will find internal consistency of
taste PE brain response between fMRI insula and striatum response and EEG signal in cingulate and frontal
cortical regions in adolescents with AN as well as age-matched healthy controls. We further expect that we will
find preliminary evidence that the EEG paradigm will be able to discriminate the AN group from the control
adolescents based on feedback related negativity and higher event-related potential amplitudes.
In Aim 2. we test whether a monetary PE paradigm will show similar EEG brain response as the taste PE in
Aim 1. to establish the generalizability of taste and non-taste paradigms.
The development of an EEG based reward PE study paradigm will enable us in the future to conduct large-
scale studies that will be less costly and independent from brain imaging centers that are only available to a
small subset of adolescents with AN.
抽象的
青少年神经性厌食症(AN)是一种饮食失调症,与对体重增加、食物的强烈恐惧有关
拒绝,体重严重下降。 AN 是青春期女性中第三大常见的慢性疾病
15-24岁女性的死亡率比预期高12倍。人们对生物标志物知之甚少
青少年 AN。使用功能磁共振成像 (fMRI) 等技术进行神经影像研究
多次建议改变 AN 中的奖励处理,包括使用多巴胺相关的研究
预测误差(PE)模型。意外收到或遗漏奖励时会引发大脑 PE 反应
刺激和思想反映了大脑多巴胺回路的功能。这是一个重要的研究方向
因为多巴胺系统可以通过药理学来操纵。患有 AN 的青少年或成人患者
显示岛叶和纹状体对重复接受蔗糖味觉的 PE 反应升高。 PE也成反比
与治疗中体重增加有关。因此,PE 大脑反应有望成为一个重要的生物标志物。
青少年 AN 对治疗结果具有预测价值。然而,功能性脑成像成本高昂,
例如,对于体内有牙套或其他金属的人来说是禁止的,并且仅在某些情况下可用
中心。为了在更大规模的研究中研究AN中的PE,需要一种更实用的方法和方法
发达。在此应用中,我们将使用探索性/开发性 R21 机制来开展一项研究
使用脑电图 (EEG) 研究青少年 AN 中的 PE 信号的协议。最近的健康研究
个人认为这是一种有效的方法。
在目标 1 中,我们测试了采用计算品味 PE 强化学习范式的可行性
患有 AN 的青少年和健康对照者的功能磁共振成像 (fMRI) 到脑电图 (EEG)。我们期望我们能找到内部一致性
fMRI 岛叶和纹状体反应之间的味觉 PE 脑反应以及扣带皮层和额叶脑电图信号
患有 AN 的青少年以及年龄匹配的健康对照的皮质区域。我们进一步期望我们将
找到初步证据表明 EEG 范式将能够区分 AN 组和对照组
青少年基于反馈相关的消极性和较高的事件相关电位幅度。
在目标 2 中,我们测试了货币 PE 范式是否会表现出与味觉 PE 类似的脑电图反应。
目标 1. 建立味觉和非味觉范式的普遍性。
基于脑电图的奖励体育研究范式的发展将使我们能够在未来进行大规模的
规模研究的成本较低,并且独立于脑成像中心,而脑成像中心仅适用于
一小部分患有 AN 的青少年。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Guido KW Frank其他文献
Guido KW Frank的其他文献
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{{ truncateString('Guido KW Frank', 18)}}的其他基金
Developing a computational electroencephalogram (EEG) paradigm to study prediction error in anorexia nervosa
开发计算脑电图 (EEG) 范式来研究神经性厌食症的预测误差
- 批准号:
9975594 - 财政年份:2020
- 资助金额:
$ 23.68万 - 项目类别:
Toward understanding dopamine receptor contributions to prediction error and reversal learning in anorexia nervosa
了解多巴胺受体对神经性厌食症预测误差和逆转学习的贡献
- 批准号:
9805065 - 财政年份:2019
- 资助金额:
$ 23.68万 - 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
- 批准号:
10307096 - 财政年份:2017
- 资助金额:
$ 23.68万 - 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
- 批准号:
10028560 - 财政年份:2017
- 资助金额:
$ 23.68万 - 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
- 批准号:
10053731 - 财政年份:2017
- 资助金额:
$ 23.68万 - 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
- 批准号:
8678582 - 财政年份:2014
- 资助金额:
$ 23.68万 - 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
- 批准号:
8914714 - 财政年份:2014
- 资助金额:
$ 23.68万 - 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
- 批准号:
9242702 - 财政年份:2014
- 资助金额:
$ 23.68万 - 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
- 批准号:
8824577 - 财政年份:2014
- 资助金额:
$ 23.68万 - 项目类别:
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia Nervosa
青少年神经性厌食症的大脑奖励回路和计算模型
- 批准号:
8517204 - 财政年份:2012
- 资助金额:
$ 23.68万 - 项目类别:
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