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Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes

暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应

基本信息

批准号：
10053731
负责人：
Guido KW Frank
金额：
$ 69.63万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-26 至 2022-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10053731
关键词：
Affect Affective Age Base of the Brain Behavior Behavioral Binge Eating Binge eating disorder Biological Brain Brain imaging Brain scan Bulimia Calories Categories Characteristics Cognition Cognitive Computer Models Control Groups Corpus striatum structure Depressed mood Diagnostic Disease Distress Dopamine Eating Eating Disorders Ecological momentary assessment Emotions Environment Exanthema Feeling Food Future Health Individual Insula of Reil Intervention Knowledge Learning Link Magnetic Resonance Measures Morbidity - disease rate Motivation National Institute of Mental Health Neurobiology Neurosciences Neurotransmitters Obesity Persons Positive Valence Prefrontal Cortex Psychological reinforcement Quality of life Randomized Recurrence Regulation Reproducibility Research Research Domain Criteria Rewards Scanning Symptoms System Taste Perception Testing Ventral Striatum Vomiting Weight base behavioral study brain circuitry brain research cognitive control dopamine system healthy weight mind control mortality negative affect obese person psychopharmacologic relating to nervous system response reward processing sex therapy development

项目摘要

Project Summary Binge-eating is characterized by recurrent episodes of eating large amounts of foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as feeling disgusted with oneself, depressed, or guilty after those episodes. Two eating disorders are characterized by binge-eating as central diagnostic criteria, bulimia nervosa (BN) and binge eating disorder (BED). Behavior studies have shown that negative affect and negative urgency (the tendency to act rashly when distressed) often drive binge-eating. A knowledge gap exists for 1) what neurobiological underpinnings are associated with negative affect that leads to loss of control and drives binge-eating, 2) whether neurotransmitter related brain circuits can be specifically linked to binge-eating, and 3) whether brain imaging can identify a brain based vulnerability for negative affect and excessive food intake in the natural environment. This application will study binge-eating across diagnostic categories, in individuals at normal weight with BN and obese individuals with BED, in contrast with normal weight or obese controls. We will apply the constructs cognitive control and positive valence system from NIMH's Research Domain Criteria (RDoC) project together with functional magnetic resonance brain imaging. In Aim 1. we will test whether negative affect alters brain reinforcement learning during a dopamine anchored taste reward paradigm. In Aim 2. we will study during a food choice paradigm the effects of negative affect on brain circuitry for cognitive control and food valuation. Aim 3. is to test whether brain activation predicts food intake or negative affect in a person's naturalistic environment, using ecological momentary assessment and meal observation. Binge-eating associated disorders are major health concerns with reduced quality of life and increased mortality rate, and the available treatments are limited. The neurobiology underlying binge-eating is not well understood and has not specifically been studied in a transdiagnostic approach using the NIMH's research domain criteria. This project will bridge affective-cognitive research knowledge with neurobiological brain research across eating disorders characterized by binge-eating as primary symptom. It will fill an important research and knowledge gap to develop intervention-directed research in the future.

项目概要暴食症的特点是反复吃大量食物，吃得更多比平时快，直到感到不舒服的饱腹感，以及对自己感到厌恶、沮丧、或在这些事件发生后感到内疚。两种饮食失调以暴食为中心诊断标准，神经性贪食症（BN）和暴食症（BED）。行为研究表明，消极情感和消极的紧迫感（在痛苦时鲁莽行事的倾向）常常会导致暴饮暴食。一个存在知识差距：1）哪些神经生物学基础与导致的负面情绪相关导致失去控制并导致暴饮暴食，2）神经递质相关的大脑回路是否可以特异性地与暴饮暴食有关，3）大脑成像是否可以识别大脑对负面情绪的脆弱性以及在自然环境中摄入过多的食物。该应用程序将研究暴食行为与 BN 正常体重个体和 BED 肥胖个体相比，诊断类别正常体重或肥胖对照。我们将应用认知控制和正价系统的构建来自 NIMH 的研究领域标准 (RDoC) 项目以及功能性磁共振大脑成像。在目标 1 中，我们将测试负面情绪是否会改变多巴胺期间的大脑强化学习锚定味觉奖励范式。在目标 2 中，我们将在食物选择范式中研究负面因素的影响对认知控制和食物评价的大脑回路的影响。目的3.测试大脑是否激活使用生态瞬时预测一个人的自然环境中的食物摄入量或负面影响评估和膳食观察。暴食相关疾病是主要的健康问题，减少了生活质量和死亡率增加，并且可用的治疗方法有限。神经生物学暴食的潜在原因尚不清楚，也没有在跨诊断中进行专门研究使用 NIMH 的研究领域标准的方法。该项目将连接情感认知研究以暴食为特征的饮食失调的神经生物学大脑研究知识主要症状。它将填补重要的研究和知识空白，以开发干预导向的方法未来的研究。