Toward understanding dopamine receptor contributions to prediction error and reversal learning in anorexia nervosa

了解多巴胺受体对神经性厌食症预测误差和逆转学习的贡献

基本信息

  • 批准号:
    9805065
  • 负责人:
  • 金额:
    $ 23.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2021-04-30
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Anorexia nervosa (AN) is an eating disorder associated with intense fear of weight gain, food refusal, and severe weight loss. AN has the highest mortality rate among the psychiatric disorders; however, little is known about biomarkers, and no medication has been approved for AN. Many individuals only partially recover, and treatment options, especially for the psychological components of the illness, are not very effective, highlighting the need for more effective treatments. Brain reward pathways have a direct impact on the drive to eat, and a variety of neuroimaging studies have suggested altered reward processing in AN. The neurotransmitter dopamine has a central role in the reward circuitry to drive food approach, and the dynamic interplay between dopamine receptor response and food restriction could have implications for the pathophysiology of AN. Dopamine-related brain function has been studied indirectly using functional magnetic resonance brain imaging (fMRI) and tasks that deliver reward stimuli unexpectedly, eliciting the so-called prediction error (PE) response. Research in AN showed repeatedly altered PE processing suggesting altered dopamine circuit function in the disorder. Dopamine and PE response have also been associated with altered reversal learning, which has important treatment implication for AN as reversal learning is impaired in the disorder and modulation of the dopamine system could improve treatment. However, the dopamine receptor mechanisms that underlie altered PE response in AN have not been studied. This could be highly important to develop medication interventions. In this application, we will develop a study protocol and gather pilot data to identify whether specific dopamine D2 challenge drugs can modulate PE response and reversal learning in AN. In Aim 1., we will apply a selective dopamine D2 receptor agonist to test its effects on PE and reversal learning. In Aim 2., we will apply a selective dopamine D2/3 receptor antagonist. We expect that those challenge drugs will lead to opposite brain and behavior response within groups and directly support the involvement of those receptors in PE and reversal learning processing. In Aim 3., we will contrast brain and behavior response across challenge drugs in AN against response in healthy controls to gather pilot data for future investigation. This research will be important to develop neurotransmitter specific pharmacological treatments for AN.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Guido KW Frank其他文献

Guido KW Frank的其他文献

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{{ truncateString('Guido KW Frank', 18)}}的其他基金

Developing a computational electroencephalogram (EEG) paradigm to study prediction error in anorexia nervosa
开发计算脑电图 (EEG) 范式来研究神经性厌食症的预测误差
  • 批准号:
    9975594
  • 财政年份:
    2020
  • 资助金额:
    $ 23.63万
  • 项目类别:
Developing a computational electroencephalogram (EEG) paradigm to study prediction error in anorexia nervosa
开发计算脑电图 (EEG) 范式来研究神经性厌食症的预测误差
  • 批准号:
    10224812
  • 财政年份:
    2020
  • 资助金额:
    $ 23.63万
  • 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
  • 批准号:
    10307096
  • 财政年份:
    2017
  • 资助金额:
    $ 23.63万
  • 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
  • 批准号:
    10028560
  • 财政年份:
    2017
  • 资助金额:
    $ 23.63万
  • 项目类别:
Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes
暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应
  • 批准号:
    10053731
  • 财政年份:
    2017
  • 资助金额:
    $ 23.63万
  • 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
  • 批准号:
    8678582
  • 财政年份:
    2014
  • 资助金额:
    $ 23.63万
  • 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
  • 批准号:
    8914714
  • 财政年份:
    2014
  • 资助金额:
    $ 23.63万
  • 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
  • 批准号:
    8824577
  • 财政年份:
    2014
  • 资助金额:
    $ 23.63万
  • 项目类别:
Taste reward circuits and prediction error define eating disorder psychopathology
味觉奖励回路和预测误差定义了饮食失调精神病理学
  • 批准号:
    9242702
  • 财政年份:
    2014
  • 资助金额:
    $ 23.63万
  • 项目类别:
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia Nervosa
青少年神经性厌食症的大脑奖励回路和计算模型
  • 批准号:
    8517204
  • 财政年份:
    2012
  • 资助金额:
    $ 23.63万
  • 项目类别:

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