权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes

暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应

基本信息

批准号：
10028560
负责人：
Guido KW Frank
金额：
$ 4.25万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-26 至 2022-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10028560
关键词：
Affect Affective Age Base of the Brain Behavior Behavioral Binge Eating Binge eating disorder Biological Brain Brain imaging Brain scan Bulimia Calories Categories Characteristics Cognition Cognitive Computer Models Control Groups Corpus striatum structure Depressed mood Diagnostic Disease Distress Dopamine Eating Eating Disorders Ecological momentary assessment Emotions Environment Exanthema Feeling Food Future Health Individual Insula of Reil Intervention Knowledge Learning Link Magnetic Resonance Measures Morbidity - disease rate Motivation National Institute of Mental Health Neurobiology Neurosciences Neurotransmitters Obesity Persons Positive Valence Prefrontal Cortex Psychological reinforcement Quality of life Randomized Recurrence Regulation Reproducibility Research Research Domain Criteria Rewards Scanning Symptoms System Taste Perception Testing Ventral Striatum Vomiting Weight base behavioral study brain circuitry brain research cognitive control dopamine system healthy weight mind control mortality negative affect psychopharmacologic relating to nervous system response reward processing sex therapy development

项目摘要

Project Summary Binge-eating is characterized by recurrent episodes of eating large amounts of foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as feeling disgusted with oneself, depressed, or guilty after those episodes. Two eating disorders are characterized by binge-eating as central diagnostic criteria, bulimia nervosa (BN) and binge eating disorder (BED). Behavior studies have shown that negative affect and negative urgency (the tendency to act rashly when distressed) often drive binge-eating. A knowledge gap exists for 1) what neurobiological underpinnings are associated with negative affect that leads to loss of control and drives binge-eating, 2) whether neurotransmitter related brain circuits can be specifically linked to binge-eating, and 3) whether brain imaging can identify a brain based vulnerability for negative affect and excessive food intake in the natural environment. This application will study binge-eating across diagnostic categories, in individuals at normal weight with BN and obese individuals with BED, in contrast with normal weight or obese controls. We will apply the constructs cognitive control and positive valence system from NIMH's Research Domain Criteria (RDoC) project together with functional magnetic resonance brain imaging. In Aim 1. we will test whether negative affect alters brain reinforcement learning during a dopamine anchored taste reward paradigm. In Aim 2. we will study during a food choice paradigm the effects of negative affect on brain circuitry for cognitive control and food valuation. Aim 3. is to test whether brain activation predicts food intake or negative affect in a person's naturalistic environment, using ecological momentary assessment and meal observation. Binge-eating associated disorders are major health concerns with reduced quality of life and increased mortality rate, and the available treatments are limited. The neurobiology underlying binge-eating is not well understood and has not specifically been studied in a transdiagnostic approach using the NIMH's research domain criteria. This project will bridge affective-cognitive research knowledge with neurobiological brain research across eating disorders characterized by binge-eating as primary symptom. It will fill an important research and knowledge gap to develop intervention-directed research in the future.

项目总结