Alzheimer's Disease Risk and Ethnic Factors: The Case of Arab Americans

阿尔茨海默病风险和种族因素：阿拉伯裔美国人的案例

• 批准号: 10225492
• 负责人: KRISTINE J. AJROUCH
• 金额: $ 77.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225492
• 关键词: African; Alzheimer' s Disease; Alzheimer' s disease risk; American; Arabs; Area; Attention; Buffers; Categories; Censuses; Characteristics; Cognition; Cognitive; Communities; Cost of Illness; Data; Diabetes Mellitus; Elderly; Ethnic group; European; Future; Geographic Locations; Health; Home; Hypertension; Immigrant; Impaired cognition; Incidence; Intervention; Knowledge; Link; Materials Testing; Measures; Medical; Memory Loss; Muslim population group; Outcome; Population; Prevalence; Prospective Studies; Reporting; Resources; Role; Sampling; Social Behavior; Social Network; Socioeconomic Factors; South Asian; Stress; Structure; Surveys; Testing; United States; cardiovascular risk factor; cost effective; disease disparity; ethnic minority population; experience; functional disability; health difference; health disparity; human old age (65+); innovation; insight; mild cognitive impairment; multiple datasets; preference; protective factors; racial and ethnic; racial diversity; social; theories

Alzheimer’s Disease Risk and Ethnic Factors: The Case of Arab Americans Alzheimer’s disease (AD) afflicts 11% of the U.S. population aged 65 and over, and half of these cases go undiagnosed. The incidence of mild cognitive impairment (MCI) and AD is higher among many racial/ ethnic minorities, but rates among Arab Americans, who possess more cardiovascular risk factors than whites, are unknown. The first of its kind, this study will collect regionally representative data from Arab Americans (N=600) aged 65 and over living in the metro-Detroit area, home to the largest and most visible Arab American community in the U.S. Additionally, we will leverage an existing sample of black and white older adults from the Survey of Social Relations (SRS) to compare and contrast prevalence of AD and the role of structural factors among Arab Americans to other populations in the same geographic area. The planned project will form the basis of a future prospective study to advance understanding of racial/ethnic health disparities in AD incidence. The specific aims are to: 1) Characterize cognition and AD risk among Arab Americans in metro-Detroit; 2) Determine the contribution of immigrant factors to cognition and AD risk among older Arab Americans; 3) Identify aspects of social networks that have greatest effects on cognition and AD risk. This project will produce currently unavailable normative data that will assist practitioners in the assessment of AD in English and Arabic speaking Arab American elders. With a focus on AD disparities, and socio-behavioral factors, these data will provide opportunities to compare to regional and national data on other racial/ethnic minorities in the quest to quantify health disparities and identify mechanisms that cause and sustain them. In addition to delineating health disparities, studying Arab Americans can refine our understanding of immigrant health in the U.S. Further, the study of social networks among diverse racial/ethnic groups will reveal how and why social ties form and function as a protective factor (direct and buffering) on cognitive health. Understanding the role of structural and cultural factors will refine theory about AD disparities and provide key information to better develop intervention strategies for effective management of this growing and high-cost disease.

阿尔茨海默病的风险和种族因素：阿拉伯裔美国人的案例 阿尔茨海默病(AD)困扰着美国11%的65岁及以上人口，其中一半的病例 未确诊。在许多种族/民族中，轻度认知障碍(MCI)和阿尔茨海默病的发生率较高 少数族裔，但在阿拉伯裔美国人中，他们比白人拥有更多的心血管危险因素， 未知。这是此类研究中的第一项，它将从阿拉伯裔美国人那里收集具有地区代表性的数据。 (n=600)65岁及以上居住在底特律大都会地区，那里是最大、最引人注目的阿拉伯裔美国人的家园 此外，我们还将利用现有的黑人和白人老年人样本 社会关系调查(SRS)，比较和对比AD的患病率和结构性因素的作用 从阿拉伯裔美国人到同一地理区域的其他人口。计划中的项目将形成 为未来的前瞻性研究奠定基础，以促进对阿尔茨海默病发病率中种族/民族健康差异的了解。 具体目标是：1)描述底特律大都会阿拉伯裔美国人的认知和AD风险；2) 确定移民因素对老年阿拉伯裔美国人认知和AD风险的贡献；3) 找出社交网络对认知和AD风险影响最大的方面。这个项目将产生 目前没有帮助从业者用英文和阿拉伯文评估AD的规范数据 会说阿拉伯裔美国长老。随着AD差异和社会行为因素的关注，这些数据将 提供机会与其他种族/族裔少数群体的区域和国家数据进行比较，以寻求 量化健康差距，并确定造成和维持这些差距的机制。除了描绘出 健康差异，研究阿拉伯裔美国人可以加深我们对美国移民健康的理解。 此外，对不同种族/民族之间的社会网络的研究将揭示社会联系的方式和原因 形式和功能是认知健康的保护因素(直接和缓冲)。了解企业的角色 结构和文化因素将完善关于AD差异的理论，并提供关键信息，以更好地 制定干预策略，有效管理这一日益增长且成本高昂的疾病。