Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans

项目摘要 脑健康与ADRD风险的种族差异：阿拉伯裔美国人的案例 阿尔茨海默病和相关痴呆症(ADRD)的发病率在美国黑人和 西班牙裔美国人比非西班牙裔白人更多，但研究中几乎没有关于阿拉伯裔美国人的数据 关于大脑和认知老化。这一未被研究的群体的独特经历有可能澄清 了解与种族、移民和社会因素有关的ADRD差异。拟议中的项目 利用首个阿拉伯裔美国人ADRD患病率研究(AG057510)检查大脑 社会文化风险/保护因素与ADRD之间潜在联系的机制。这样做的目的是 研究旨在调查移民/文化因素、大脑健康和临床结果之间的联系。 与ADRD有关。以下具体目标将通过获得结构性核磁共振和基于血液的 底特律-老龄化和记忆项目(D-AMP)中的AD生物标志物数据，该项目获得高质量的ADRD 来自600名阿拉伯裔美国人的代表性样本中65岁以上人群的表型和基因数据也是如此 作为社会关系研究(SRS)的小组参与者(N=298)，与非阿拉伯人的样本进行比较 白人在同一地理区域。我们的具体目标是： 1)量化底特律大都会区阿拉伯裔美国人和白人在脑老化方面的差异，并确定 脑健康对ADRD群体差异的贡献； 2)确定移民/文化因素(例如，国籍、移民年龄)对大脑的贡献 阿拉伯裔美国人的老龄化； 3)描述社会关系对阿拉伯裔美国人大脑和认知老化的影响 白色的。 拟议的研究得益于特殊情况，利用了独特的样本和数据， 首次确定老年阿拉伯裔美国人的神经影像和基于血液的AD生物标记物的特征。 这些知识对于制定和评估预防和干预战略也是至关重要的。 作为这种文化裁剪的努力，以确保在不同的社会文化群体中的效力，以消除 差距。

Project Summary Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans The incidence of Alzheimer’s disease and related dementia (ADRD) is higher in Black Americans and Hispanics than in non-Hispanic Whites, but data on Arab Americans have been virtually absent from research on brain and cognitive aging. The unique experiences of this understudied group have the potential to clarify knowledge of ADRD disparities related to ethnicity, immigrant and social factors. The proposed project leverages the first prevalence study of ADRD among Arab Americans (AG057510) to examine brain mechanisms underlying links between sociocultural risk/protective factors and ADRD. The purpose of this research is to investigate the links between immigrant/cultural factors, brain health, and clinical outcomes related to ADRD. The following specific aims will be accomplished by obtaining structural MRI and blood-based AD biomarker data in the Detroit-Aging and Memory Project (D-AMP), which obtains high-quality ADRD phenotypes and genetic data on those aged 65+ from a representative sample of 600 Arab Americans, as well as panel participants (N=298) from the Social Relations Study (SRS), to compare to samples of non-Arab Whites in the same geographic area. Our specific aims are: 1) Quantify differences in brain aging among Arab Americans and Whites in metro-Detroit and determine the contribution of brain health to group differences in ADRD; 2) Determine the contribution of immigrant/cultural factors (e.g., national origin, age of migration) to brain aging among Arab Americans; 3) Characterize the influence of social relations on brain and cognitive aging among Arab Americans and Whites. The proposed study benefits from exceptional circumstances, leveraging a uniquely available sample and data, to characterize, for the first time, neuroimaging and blood-based AD biomarkers among older Arab Americans. This knowledge is critical for the development and evaluation of prevention and intervention strategies, as well as the cultural tailoring of such efforts to ensure efficacy in different sociocultural groups in order to eliminate disparities.