Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans

项目摘要 脑健康和ADRD风险的种族差异：阿拉伯裔美国人的情况 阿尔茨海默病和相关痴呆症（ADRD）的发病率在美国黑人中较高， 西班牙裔美国人比非西班牙裔白人，但阿拉伯裔美国人的数据几乎没有研究 关于大脑和认知老化的研究这个未被充分研究的群体的独特经历有可能澄清 了解与种族、移民和社会因素有关的ADRD差异。拟建项目 利用阿拉伯裔美国人中ADRD的第一项患病率研究（AG 057510）， 社会文化风险/保护因素与ADRD之间联系的潜在机制。这样做的目的 研究是调查移民/文化因素，大脑健康和临床结果之间的联系 与ADRD有关。以下具体目标将通过获得结构MRI和基于血液的 底特律老龄化和记忆项目（D-AMP）中的AD生物标志物数据，该项目获得了高质量的ADRD 来自600名阿拉伯裔美国人代表性样本的65岁以上人群的表型和遗传数据， 作为社会关系研究（SRS）的小组参与者（N=298），与非阿拉伯人样本进行比较 白人在同一个地理区域。我们的具体目标是： 1)量化底特律大都会区阿拉伯裔美国人和白人大脑老化的差异， 脑健康对ADRD组间差异的贡献; 2)确定移民/文化因素的贡献（例如，国籍、移民年龄） 阿拉伯裔美国人的老龄化; 3)描述社会关系对阿拉伯裔美国人大脑和认知老化的影响， 白人 拟议的研究受益于特殊情况，利用独特的可用样本和数据， 首次在阿拉伯裔美国老年人中描述神经影像学和血液AD生物标志物。 这种知识对于制定和评价预防和干预战略也是至关重要的 由于这种努力的文化适应性，以确保在不同的社会文化群体中的效力， 差距。

Project Summary Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans The incidence of Alzheimer’s disease and related dementia (ADRD) is higher in Black Americans and Hispanics than in non-Hispanic Whites, but data on Arab Americans have been virtually absent from research on brain and cognitive aging. The unique experiences of this understudied group have the potential to clarify knowledge of ADRD disparities related to ethnicity, immigrant and social factors. The proposed project leverages the first prevalence study of ADRD among Arab Americans (AG057510) to examine brain mechanisms underlying links between sociocultural risk/protective factors and ADRD. The purpose of this research is to investigate the links between immigrant/cultural factors, brain health, and clinical outcomes related to ADRD. The following specific aims will be accomplished by obtaining structural MRI and blood-based AD biomarker data in the Detroit-Aging and Memory Project (D-AMP), which obtains high-quality ADRD phenotypes and genetic data on those aged 65+ from a representative sample of 600 Arab Americans, as well as panel participants (N=298) from the Social Relations Study (SRS), to compare to samples of non-Arab Whites in the same geographic area. Our specific aims are: 1) Quantify differences in brain aging among Arab Americans and Whites in metro-Detroit and determine the contribution of brain health to group differences in ADRD; 2) Determine the contribution of immigrant/cultural factors (e.g., national origin, age of migration) to brain aging among Arab Americans; 3) Characterize the influence of social relations on brain and cognitive aging among Arab Americans and Whites. The proposed study benefits from exceptional circumstances, leveraging a uniquely available sample and data, to characterize, for the first time, neuroimaging and blood-based AD biomarkers among older Arab Americans. This knowledge is critical for the development and evaluation of prevention and intervention strategies, as well as the cultural tailoring of such efforts to ensure efficacy in different sociocultural groups in order to eliminate disparities.