Development of Psychopathology: From Brain and Behavioral Science to Intervention

精神病理学的发展：从大脑和行为科学到干预

• 批准号: 10402269
• 负责人: DAVID A. COLE
• 金额: $ 31.97万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10402269
• 关键词: Behavioral Sciences; Brain; Development; Intervention; Psychopathology

PROJECT SUMMARY This application is for a 5-year renewal of the T32 Training Program in the Development of Psychopathology: From Brain and Behavior to Intervention. Because mental and substance abuse disorders are more likely to arise early in life, early identification of risk processes and early intervention are crucial (Insel, 2014). As the field has been shifting from a behavioral to a neurodevelopmental focus, this training program also has evolved to reflect important advances in human brain development. The major thrust of this interdisciplinary program is to produce scientists who will (1) contribute to the state of knowledge about neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (2) translate findings from basic research to the construction of empirically-based interventions for the prevention and amelioration of psychopathology and for the promotion of mental health. This training program provides individual mentoring in multidisciplinary science complemented by didactic activities. A personalized training plan is developed for each fellow and re-evaluated each semester. In the last five years, we have continued to increase training on multidisciplinary research on neurobiological, psychophysiological, genetic, and psychosocial mechanisms underlying psychiatric illness. To this end, we have made some changes to our core, training faculty. All 24 faculty are currently funded, with 75% as PIs on at least one grant, and the others serving as co-PIs or investigators. Two-thirds of our current training faculty are actively involved in neuroscience research. Another 54% of our faculty conduct intervention studies aimed at reducing or preventing psychiatric problems including depression, anxiety, and substance use. In the last decade, all of our 26 pre- and 10 post-doctoral trainees have continued to contribute to the field through scholarly research, teaching, and administration. Three predocs remain in training on this T32; 2 former trainees are working on their dissertations; 4 are doing their required clinical internship. All 17 remaining former predoc trainees have completed their PhDs; 4 are engaged in research intensive faculty positions in academic departments of psychology or medicine; 3 are doing research intensive postdoctoral fellowships. The remaining 10 former predoc trainees are doing some research related work including teaching, supervision, or administration. Of the 10 postdoctoral fellows, 2 are still in training; 6 of the 8 (75%) former postdocs are actively involved in research intensive faculty positions and all have received some kind of external funding (e.g., K’s; R01, Foundations). In the past 10 years, 22% of all trainees were from under- represented ethnic minority or economically disadvantaged groups; 83% are female. This renewal application proposes to again support 4 predoctoral and 2 postdoctoral trainees annually. Goals for the next 5 years are to continue to train independent research scientists who can discover and translate basic knowledge from clinical neuroscience into interventions for reducing psychopathology.

项目概要 此申请适用于精神病理学发展 T32 培训计划的 5 年续展： 从大脑和行为到干预。因为精神和药物滥用障碍更有可能 由于风险发生在生命早期，因此早期识别风险过程和早期干预至关重要（Insel，2014）。作为场 已经从行为重点转向神经发育重点，该培训计划也已发展为 反映了人类大脑发育的重要进展。这个跨学科项目的主要目标是 培养能够 (1) 为神经生物学和心理社会知识水平做出贡献的科学家 精神病理学发展和维持的机制，以及（2）转化来自 基础研究，构建基于经验的干预措施，以预防和改善 精神病理学和促进心理健康。该培训计划提供个人指导 多学科科学辅以教学活动。为每个人制定个性化的培训计划 研究员并每学期重新评估。五年来，我们不断加大培训力度 神经生物学、心理生理学、遗传和心理社会机制的多学科研究 潜在的精神疾病。为此，我们对我们的核心培训师资队伍进行了一些改变。全部 24 项 目前，教职人员均获得资助，其中 75% 作为 PI 获得至少一项资助，其他人担任联合 PI 或 调查人员。我们目前三分之二的培训教师积极参与神经科学研究。其他 我们 54% 的教师进行干预研究，旨在减少或预防精神问题，包括 抑郁、焦虑和药物滥用。在过去的十年里，我们所有的26名博士前和10名博士后学员 通过学术研究、教学和管理继续为该领域做出贡献。三个博士预科生 继续接受这架 T32 的训练； 2名前学员正在撰写论文； 4 正在做他们所需要的 临床实习。剩下的 17 名前博士生均已完成博士学位； 4人从事研究工作 心理学或医学学术系的密集教职； 3 正在进行密集研究 博士后奖学金。剩下的 10 名前博士生正在做一些研究相关的工作 包括教学、监督或管理。 10名博士后中，2名仍在培训中； 8 个中的 6 个 (75%) 前博士后积极参与研究密集型教师职位，并且所有人都获得了一些 外部资金的类型（例如 K’s；R01、基金会）。过去10年，22%的学员来自底层 代表少数族裔或经济弱势群体； 83%是女性。本次续签申请 提议每年再次资助4名博士前培训生和2名博士后培训生。未来5年的目标是 继续培养能够发现和转化临床基础知识的独立研究科学家 神经科学融入减少精神病理学的干预措施。