Development of Psychopathology: From Brain and Behavioral Science to Intervention

项目摘要 此申请是为了在精神病理学的发展T32培训计划的5年更新： 从大脑和行为到干预。因为精神和物质滥用障碍更有可能 在生命早期出现，早期识别风险过程和早期干预至关重要（Insel，2014年）。随着该领域 已经从行为转向神经发育的重点，这种训练计划也已经发展到 反映了人类大脑发育的重要进展。这个跨学科计划的主要目的是 培养出（1）对神经生物学和社会心理学的知识做出贡献的科学家 精神病理学的发展和维持的潜在机制，以及（2）将研究结果从 基础研究，以建立基于医疗的干预措施，预防和改善 精神病理学和促进心理健康。该培训计划提供个人指导， 多学科科学，辅以教学活动。为每个人制定个性化的培训计划 每个学期都要重新评估。在过去五年中，我们继续增加培训， 神经生物学、心理生理学、遗传学和心理社会机制的多学科研究 潜在的精神疾病为此，我们对我们的核心培训教师进行了一些改革。所有24 教师目前的资助，75%作为PI的至少一个赠款，和其他人作为共同PI或 investigators.我们目前的培训教师的三分之二积极参与神经科学研究。另一 54%的教师进行干预研究，旨在减少或预防精神问题，包括 抑郁焦虑和药物滥用在过去的十年里，我们所有的26名博士前和10名博士后学员 继续通过学术研究，教学和管理为该领域做出贡献。三个predocs 继续在这个T32培训; 2名前学员正在他们的论文工作; 4人正在做他们的要求 临床实习其余17名前predoc学员均已完成博士学位; 4人从事研究工作 心理学或医学学术部门的密集型教师职位; 3人正在进行密集型研究 博士后奖学金剩下的10名前predoc学员正在做一些研究相关的工作 包括教学、监督或管理。在10名博士后研究员中，2名仍在接受培训; 8名博士后研究员中有6名正在接受培训。 (75%）前博士后积极参与研究密集型教师职位， 外部资金的种类（例如，K's; R 01，基础）。在过去10年中，22%的学员来自- 代表少数民族或经济弱势群体; 83%为女性。这份更新申请 建议每年再次支持4名博士前和2名博士后培训人员。未来五年的目标是 继续培养独立的研究科学家，他们可以从临床中发现和翻译基础知识， 将神经科学引入到减少精神病理学的干预措施中。

PROJECT SUMMARY This application is for a 5-year renewal of the T32 Training Program in the Development of Psychopathology: From Brain and Behavior to Intervention. Because mental and substance abuse disorders are more likely to arise early in life, early identification of risk processes and early intervention are crucial (Insel, 2014). As the field has been shifting from a behavioral to a neurodevelopmental focus, this training program also has evolved to reflect important advances in human brain development. The major thrust of this interdisciplinary program is to produce scientists who will (1) contribute to the state of knowledge about neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (2) translate findings from basic research to the construction of empirically-based interventions for the prevention and amelioration of psychopathology and for the promotion of mental health. This training program provides individual mentoring in multidisciplinary science complemented by didactic activities. A personalized training plan is developed for each fellow and re-evaluated each semester. In the last five years, we have continued to increase training on multidisciplinary research on neurobiological, psychophysiological, genetic, and psychosocial mechanisms underlying psychiatric illness. To this end, we have made some changes to our core, training faculty. All 24 faculty are currently funded, with 75% as PIs on at least one grant, and the others serving as co-PIs or investigators. Two-thirds of our current training faculty are actively involved in neuroscience research. Another 54% of our faculty conduct intervention studies aimed at reducing or preventing psychiatric problems including depression, anxiety, and substance use. In the last decade, all of our 26 pre- and 10 post-doctoral trainees have continued to contribute to the field through scholarly research, teaching, and administration. Three predocs remain in training on this T32; 2 former trainees are working on their dissertations; 4 are doing their required clinical internship. All 17 remaining former predoc trainees have completed their PhDs; 4 are engaged in research intensive faculty positions in academic departments of psychology or medicine; 3 are doing research intensive postdoctoral fellowships. The remaining 10 former predoc trainees are doing some research related work including teaching, supervision, or administration. Of the 10 postdoctoral fellows, 2 are still in training; 6 of the 8 (75%) former postdocs are actively involved in research intensive faculty positions and all have received some kind of external funding (e.g., K’s; R01, Foundations). In the past 10 years, 22% of all trainees were from under- represented ethnic minority or economically disadvantaged groups; 83% are female. This renewal application proposes to again support 4 predoctoral and 2 postdoctoral trainees annually. Goals for the next 5 years are to continue to train independent research scientists who can discover and translate basic knowledge from clinical neuroscience into interventions for reducing psychopathology.