VCU Massey Cancer Center Minority/Underserved NCI Community Oncology Research Program

项目摘要 弗吉尼亚联邦大学（VCU）梅西癌症中心（MCC）将作为主要组成部分 NCORP少数民族/服务不足社区网站（MU-NCORP）UG 1奖的网站，与6 在弗吉尼亚州的联邦合作社区附属网站。MCC中超过30%的患者 MU-NCORP来自少数民族，主要是非洲裔美国人。该提案强调了独特的 城市和农村人口提供给MCC MU-NCORP， 卫生保健提供者和专家，特别是外科医生，儿科/AYA肿瘤学家，妇科医生， 放射肿瘤学家、神经肿瘤学家和临床研究中的医学肿瘤学家，以及VCU在 在弗吉尼亚州的农村地区进行癌症外展。这个以社区为基础的NCORP，重点是 参与少数民族的临床研究，最初是作为一个以少数民族为基础的社区资助 临床肿瘤学计划于1990年成立，并一直得到资助，包括自2014年以来作为MU-NCORP。 MCC MU-NCORP与5个研究基地（肿瘤学临床试验联盟， 儿童肿瘤学小组、ECOG-ACRIN癌症研究小组、NRG肿瘤学和维克森林 NCORP研究基地）。我们的申请描述了与研究基地的工作关系， MCC MU-NCORP的重点是在癌症控制方面吸引大量的少数群体参与者， 预防、治疗/成像和癌症护理提供临床研究。工作关系 主要站点的调查员、研究人员和附属站点的支持人员也被描述。 因此，这项建议的具体目标是：（1）增加种族/族裔的总入学人数， 在我们的集水区的农村人口，以国家癌症研究所批准的研究，更注重癌症控制 研究，癌症预防研究和癌症护理提供研究（CCDR），除了癌症 治疗研究;（2）与NCORP研究基地合作，（i）提供相关性的见解 在概念发展过程中的社区实践，（ii）确定我们的集水区的护理差异， （iii）在概念和方案制定期间提供关于可行性的投入;（3） 超过CCDR方案所要求的年度最低参与人数;（4）参与生物标本 收集生物库，作为NCORP研究基地的科学资源;（5）参与 NCORP计划，如DCP-001，记录临床试验入组的筛选工作，并解决 癌症健康差距。 建议的研究与NCI的使命相关，因为MCC和社区附属机构将带来 癌症临床试验和研究，以低收入，少数民族和医疗服务不足的个人， 否则就无法获得此类研究。针对少数群体/得不到充分服务的人口， 社区是缓解这些人群中普遍存在的癌症护理差异的关键一步。

PROJECT SUMMARY Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) will serve as the primary component site for an NCORP Minority/Underserved Community Site (MU-NCORP) UG1 award in partnership with 6 collaborating community affiliate sites in the Commonwealth of Virginia. Over 30% of patients seen in the MCC MU-NCORP are from minority populations, primarily African Americans. This proposal emphasizes the unique urban and rural population available to the MCC MU-NCORP, the history of extensive participation by primary health care providers and specialists, in particular, surgeons, pediatric/AYA oncologists, gynecologic surgeons, radiation oncologists, neuro-oncologists, and medical oncologists in clinical research, and VCU initiatives in cancer outreach conducted at rural sites across Virginia. This community-based NCORP, focused on participation in clinical research of minority populations, was initially funded as a Minority-Based Community Clinical Oncology Program in 1990 and has been continuously funded, including since 2014 as a MU-NCORP. The MCC MU-NCORP has affiliations with 5 Research Bases (Alliance for Clinical Trials in Oncology, Children’s Oncology Group, ECOG-ACRIN Cancer Research Group, NRG Oncology, and the Wake Forest NCORP Research Base). Our application describes the working relationships with the Research Bases and the focus of the MCC MU-NCORP to accrue significant numbers of minority participants in cancer control and prevention, treatment/imaging, and cancer care delivery clinical research studies. Working relationships of the primary site’s investigators, research staff, and support personnel with the affiliate sites are also described. Accordingly, the specific aims of this proposal are (1) to increase the overall enrollment of racial/ethnic and rural populations in our catchment areas to NCI-approved studies, with a greater focus on cancer control research, cancer prevention research, and cancer care delivery research (CCDR), in addition to cancer treatment research; (2) to collaborate with the NCORP Research Bases by (i) providing insight into relevance for community practices during concept development, (ii) identifying care disparities our catchment areas that should be studied, and (iii) providing input on feasibility during concept and protocol development; (3) to exceed the required annual minimum participation in CCDR protocols; (4) to participate in biospecimen collection for biobanks that serve as scientific resources for NCORP Research Bases; and (5) to participate in NCORP initiatives, such as DCP-001, to document screening efforts for clinical trial enrollment and to address cancer health disparities. The proposed research is relevant to the mission of the NCI as MCC and the community affiliates will bring cancer clinical trials and research to low-income, minority, and medically underserved individuals who otherwise would not have access to such studies. Targeting the minority/underserved populations in their communities is a critical step toward alleviating the cancer care disparities prevalent in these populations.