VCU Massey Cancer Center Minority/Underserved NCI Community Oncology Research Program

项目总结 弗吉尼亚联邦大学梅西癌症中心(MCC)将作为主要组成部分 NCORP少数族裔/服务不足社区站点(MU-NCORP)UG1奖的站点与6 弗吉尼亚州联邦的合作社区附属网站。超过30%的患者在MCC就诊 MU-NCORP来自少数族裔，主要是非裔美国人。这项建议强调了独特的 城市和农村人口可用MCC MU-NCORP，历史上广泛参与的小学 保健提供者和专家，特别是外科医生、儿科/AYA肿瘤学家、妇科外科医生、 临床研究中的放射肿瘤学家、神经肿瘤学家和医学肿瘤学家，以及VCU倡议 在弗吉尼亚州的农村地区进行了癌症外展。这个以社区为基础的NCORP，专注于 参与少数群体的临床研究，最初是作为一个以少数群体为基础的社区提供资金的 临床肿瘤学计划于1990年启动，并一直得到持续资助，包括自2014年以来作为MU-NCORP获得资助。 MCC MU-NCORP与5个研究基地(肿瘤学临床试验联盟， 儿童肿瘤学小组、ECOG-ACRIN癌症研究小组、NRG肿瘤学和维克森林 NCORP研究基地)。我们的应用程序描述了与研究基地和 MCC MU-NCORP的重点是吸引大量少数族裔参与者参与癌症控制和 预防、治疗/成像和癌症护理提供临床研究。两国政府的工作关系 主要站点的调查人员、研究人员和附属站点的支持人员也进行了描述。 因此，这项提案的具体目标是：(1)增加种族/族裔和 将我们集水区的农村人口转移到NCI批准的研究，更多地关注癌症控制 除癌症外，研究、癌症预防研究和癌症护理提供研究(CCDR) 治疗研究；(2)通过以下方式与NCORP研究基地合作：(I)提供对相关性的见解 对于概念发展过程中的社区做法，(2)确定我们的集水区存在的护理差距 应进行研究，以及(3)在概念和议定书制定过程中就可行性提供意见；(3) 超过CCDR议定书规定的年度最低参与量；(4)参加生物质检 收集作为NCORP研究基地科学资源的生物库；和(5)参与 NCORP倡议，如DCP-001，以记录临床试验登记的筛查工作并解决 癌症健康差距。 拟议的研究与NCI的使命相关，因为MCC和社区附属机构将带来 癌症临床试验和研究面向低收入、少数族裔和医疗服务不足的个人 否则就无法接触到这样的研究。以少数族裔/未得到充分服务的人口为目标 社区是缓解这些人群中普遍存在的癌症护理差距的关键一步。

PROJECT SUMMARY Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) will serve as the primary component site for an NCORP Minority/Underserved Community Site (MU-NCORP) UG1 award in partnership with 6 collaborating community affiliate sites in the Commonwealth of Virginia. Over 30% of patients seen in the MCC MU-NCORP are from minority populations, primarily African Americans. This proposal emphasizes the unique urban and rural population available to the MCC MU-NCORP, the history of extensive participation by primary health care providers and specialists, in particular, surgeons, pediatric/AYA oncologists, gynecologic surgeons, radiation oncologists, neuro-oncologists, and medical oncologists in clinical research, and VCU initiatives in cancer outreach conducted at rural sites across Virginia. This community-based NCORP, focused on participation in clinical research of minority populations, was initially funded as a Minority-Based Community Clinical Oncology Program in 1990 and has been continuously funded, including since 2014 as a MU-NCORP. The MCC MU-NCORP has affiliations with 5 Research Bases (Alliance for Clinical Trials in Oncology, Children’s Oncology Group, ECOG-ACRIN Cancer Research Group, NRG Oncology, and the Wake Forest NCORP Research Base). Our application describes the working relationships with the Research Bases and the focus of the MCC MU-NCORP to accrue significant numbers of minority participants in cancer control and prevention, treatment/imaging, and cancer care delivery clinical research studies. Working relationships of the primary site’s investigators, research staff, and support personnel with the affiliate sites are also described. Accordingly, the specific aims of this proposal are (1) to increase the overall enrollment of racial/ethnic and rural populations in our catchment areas to NCI-approved studies, with a greater focus on cancer control research, cancer prevention research, and cancer care delivery research (CCDR), in addition to cancer treatment research; (2) to collaborate with the NCORP Research Bases by (i) providing insight into relevance for community practices during concept development, (ii) identifying care disparities our catchment areas that should be studied, and (iii) providing input on feasibility during concept and protocol development; (3) to exceed the required annual minimum participation in CCDR protocols; (4) to participate in biospecimen collection for biobanks that serve as scientific resources for NCORP Research Bases; and (5) to participate in NCORP initiatives, such as DCP-001, to document screening efforts for clinical trial enrollment and to address cancer health disparities. The proposed research is relevant to the mission of the NCI as MCC and the community affiliates will bring cancer clinical trials and research to low-income, minority, and medically underserved individuals who otherwise would not have access to such studies. Targeting the minority/underserved populations in their communities is a critical step toward alleviating the cancer care disparities prevalent in these populations.