Developmental Neuroscience and Child Psychopathology

发展神经科学和精神病理学是一个迅速发展的领域，取得了既定的成功和 在了解精神疾病的致病途径和机制方面具有巨大潜力。这 专注于这一领域的T32由Luby博士和Bch博士共同领导(在 发展精神病理学和神经科学)，并在第一个供资周期中非常成功， 享受竞争激烈的国家申请者池，并成功推出所有年轻的科学家 到目前为止已经完成了这个项目。我们寻求更新和扩大这项培训赠款，增加新的专业知识 在更广泛的神经成像测量中，以及在神经效应方面具有专业知识的新教师导师 肠道微生物群的。从公共卫生的角度来看，在以下领域注入新的研究科学家 发展神经科学和精神病理学是一个高度优先的领域。拟议的多学科培训 方法由一个概念模型指导，该模型检查情绪、认知、行为、神经生物学和 从发展的角度看精神病理学的遗传和环境问题。此外，这一培训 该计划的指导思想是认识到精神障碍的风险、发病和病程 通过大脑发育过程的复杂相互作用而产生，这些过程受到心理社会、遗传和 生物(包括肠道微生物)因素，从子宫开始相互作用并贯穿整个过程 发展。圣路易斯华盛顿大学(WUSTL)的许多调查人员都有丰富的记录 在儿童神经成像和相关方法的许多方面的经验，包括侧重于结构和 儿童早期的功能性磁共振检查、诱发反应电位(ERP)和 高密度漫反射光学断层扫描(HD-DOT)。此外，WUSTL在中国拥有国际声誉 精神病学遗传学和肠道微生物组的工作，许多研究人员可以带来行为和 分子遗传学方法与理解发育精神病理学的神经生物学有关。 该计划的导师拥有丰富的可用数据库，这些数据库来自于纵向研究，其中包括 它开始于儿童早期和子宫内。该计划的导师提供独特的多学科培训 考虑到已建立的合作关系，为追求这一关注童年的令人兴奋的领域提供了一个环境 在WUSTL医学院临床和基础部门的儿童研究人员之间，以及国家 WUSTL的神经科学和神经成像项目一直处于发展的前沿 认知和情感神经科学。此外，基础和临床研究人员之间的互动 发展神经科学为培养下一代年轻科学家提供了一个持续不断的机会 谁可以从CORE的角度追问精神病理学的发展病因学 人类行为的心理和神经机制，可以告知和跨越传统的界限 精神病理学，NIMH研究领域标准倡议(RDoC)的核心方法。

Developmental neuroscience and psychopathology is a rapidly growing domain with established success and great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This T32, which is focused on this domain, is co-led by Drs. Luby and Barch (with complimentary expertise in developmental psychopathology and neuroscience), and has been very successful in the first cycle of funding, enjoying a highly competitive national applicant pool and successfully launching all of the young scientists who have completed the program thus far. We seek to renew and expand this training grant, adding new expertise in a wider range of neuroimaging measures, as well as new faculty mentors with expertise in the neural effects of the gut microbiome. From a public health perspective, an infusion of new research scientists in the area of developmental neuroscience and psychopathology is a high priority. The proposed multi-disciplinary training approach is guided by a conceptual model that examines emotional, cognitive, behavioral, neurobiological and genetic and environmental aspects of psychopathology from a developmental perspective. Further, this training program is guided by a perspective that recognizes that the risk, onset, and course of psychiatric disorders arises through a complex interplay of brain developmental processes influenced by psychosocial, genetic, and biological (including gut microbial) factors that interact beginning in utero and continue throughout development. Numerous investigators at Washington University in St. Louis (WUSTL) have a rich track record of experience in many aspects of child neuroimaging and related methods, including a focus on structural and functional magnetic resonance approaches in very early childhood, evoked response potentials (ERP) and high density diffuse optical tomography (HD-DOT). Further, WUSTL has an international reputation in psychiatric genetics and gut microbiome work, with many investigators who can bring both behavioral and molecular genetic approaches to bear on understanding the neurobiology of developmental psychopathology. The program mentors have a rich body of available databases derived from longitudinal studies, several of which began in early childhood and in utero. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting domain focused on childhood, given the established collaborations between child researchers in the WUSTL School of Medicine clinical and basic departments, and the state of the program in neuroscience and neuroimaging at WUSTL that has been at the forefront of developmental cognitive and affective neuroscience. Further, interactions between researchers in basic and clinical developmental neuroscience offer an ongoing opportunity to help train the next generation of young scientists who can pursue questions about the developmental etiology of psychopathology from the perspective of core psychological and neural mechanisms of human behavior that can inform and span traditional boundaries of psychopathology, an approach central to the NIMH Research Domain Criteria Initiative (RDOC).