Fragile Families: The Third Generation

脆弱家庭：第三代

• 批准号: 10298556
• 负责人: DANIEL A. NOTTERMAN
• 金额: $ 85.04万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-19 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10298556
• 关键词: Adolescence; Adolescent; Adopted; Adoption; Adult; Affect; Behavior; Biological; Biological Factors; Birth; Characteristics; Child; Child Rearing; Child Welfare; Cohort Studies; Competence; DNA; DNA Methylation; Data; Data Collection; Data Set; Development; Economics; Enrollment; Environmental Risk Factor; Epigenetic Process; Family; Fathers; Female; Foundations; Future; Generations; Genes; Genetic; Genotype; Health; Household; Household and Family; Immune; Immune system; Inequality; Investigation; Lead; Length; Life Cycle Stages; Living Arrangement; Measures; Mothers; Neonatal; Parents; Pattern; Perinatal; Physical environment; Postpartum Period; Poverty; Pregnancy; Probability Samples; Process; Readiness; Reporting; Ribosomal RNA; Running; Sampling; Schools; Shapes; Siblings; Social Environment; Surveys; Time; base; cohort; experience; fecal microbiome; gene environment interaction; health disparity; infancy; intergenerational; kindergarten; male; metagenomic sequencing; microbiome; middle childhood; novel; perinatal health; prenatal; prepregnancy; psychologic; recruit; resilience; saliva sample; same-sex partnership; social factors; sociodemographics; stool sample; success; telomere; transmission process

ABSTRACT The intergenerational persistence of poor health and poverty and the quest to understand underlying processes underscore the importance of rich multigenerational data. Very few existing datasets contain comprehensive information on social, environmental, and biological factors over the life course and across generations; lack of such data has limited attempts to identify the processes shaping health disparities, economic inequalities, and causal linkages between the two. The Fragile Families and Child Wellbeing Study (FF) is the longest running birth cohort study in the U.S. that is based on a national probability sample. It follows parents (G1, for Generation 1)—both mothers and fathers—and their children (G2) who were born in 1998–2000. The G2 children are now having children of their own. We propose to expand the FF study by conducting a perinatal survey on the health of the third generation (G3) children, early parenthood experiences of G2, and the characteristics of households and families into which G3 are born, as well as collecting saliva samples from the G3 children and their non-FF parents and stool samples from the G3 children; we refer to this project as the FFG3 study. The augmented data will have many unique and valuable features, including: (1) three generations of sociodemographic, environmental, and biological data; (2) extensive data on parenting in two generations (G1 and G2); (3) data on siblings and half-siblings (in G3); (4) genetic data on trios (G3 children and both of their parents); and (5) comprehensive data on perinatal health (pre-pregnancy, prenatal, delivery, neonatal, and postpartum factors) and circumstances in two generations (G2 & G3). The FFG3 study will facilitate novel and important analyses of intergenerational transmission of health, intergenerational relationships within families, and gene*environment effects on health. It will also provide an essential foundation for future G3 data collection at subsequent developmental transitions including school readiness at the transition to school, and health and development in middle childhood, adolescence, and the transition to adulthood.

摘要 健康状况不佳和贫困的代际持续存在以及对了解其根本原因的探索 进程强调了丰富的多代数据的重要性。现有的数据集很少包含 关于生命过程中社会、环境和生物因素的全面信息， 由于缺乏这类数据，无法确定形成健康差距的过程， 经济不平等，以及两者之间的因果关系。脆弱家庭与儿童福祉研究 (FF)是美国基于国家概率样本的最长的出生队列研究。它 跟随父母（G1，第一代）-母亲和父亲-和他们的孩子（G2）出生在 1998-2000. G2的孩子们现在有了自己的孩子。我们建议扩大FF研究， 对第三代（G3）儿童的健康状况进行围产期调查， G3出生的家庭和家庭的特征，以及收集唾液 G3儿童及其非FF父母的样本和G3儿童的粪便样本;我们参考 这个项目被称为FFG 3研究。增强的数据将具有许多独特和有价值的功能，包括： (1)三代人的社会人口、环境和生物数据;（2）关于养育子女的广泛数据 两代（G1和G2）;（3）同胞和半同胞数据（G3）;（4）三人组（G3）的遗传数据 儿童及其父母）;以及（5）关于围产期健康的全面数据（怀孕前，产前， 分娩、新生儿和产后因素）和两代人（G2和G3）的情况。FFG 3研究 将有助于对健康的代际传递、代际传播和 家庭内的关系，以及基因和环境对健康的影响。它还将提供一个重要的 为今后在随后的发展过渡阶段收集G3数据奠定基础，包括 向学校过渡，以及儿童中期、青少年的健康和发展， 成年