Fragile Families: The Third Generation

脆弱家庭：第三代

• 批准号: 10471323
• 负责人: DANIEL A. NOTTERMAN
• 金额: $ 83.59万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-19 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471323
• 关键词: Adolescence; Adolescent; Adopted; Adoption; Adult; Affect; Behavior; Biological; Biological Factors; Birth; Characteristics; Child; Child Rearing; Child Welfare; Cohort Studies; Competence; DNA; DNA Methylation; Data; Data Collection; Data Set; Development; Economics; Enrollment; Environmental Risk Factor; Epigenetic Process; Family; Fathers; Female; Foundations; Future; Generations; Genes; Genetic; Genotype; Health; Household; Household and Family; Immune; Immune system; Inequality; Investigation; Lead; Length; Life Cycle Stages; Living Arrangement; Measures; Mothers; Neonatal; Parents; Pattern; Perinatal; Physical environment; Postpartum Period; Poverty; Pregnancy; Probability Samples; Process; Readiness; Reporting; Ribosomal RNA; Running; Sampling; Schools; Shapes; Siblings; Social Environment; Surveys; Time; base; cohort; experience; fecal microbiome; gene environment interaction; health disparity; infancy; intergenerational; kindergarten; male; metagenomic sequencing; microbiome; middle childhood; novel; perinatal health; prenatal; prepregnancy; psychologic; recruit; resilience; saliva sample; same-sex partnership; social factors; sociodemographics; stool sample; success; telomere; transmission process

ABSTRACT The intergenerational persistence of poor health and poverty and the quest to understand underlying processes underscore the importance of rich multigenerational data. Very few existing datasets contain comprehensive information on social, environmental, and biological factors over the life course and across generations; lack of such data has limited attempts to identify the processes shaping health disparities, economic inequalities, and causal linkages between the two. The Fragile Families and Child Wellbeing Study (FF) is the longest running birth cohort study in the U.S. that is based on a national probability sample. It follows parents (G1, for Generation 1)—both mothers and fathers—and their children (G2) who were born in 1998–2000. The G2 children are now having children of their own. We propose to expand the FF study by conducting a perinatal survey on the health of the third generation (G3) children, early parenthood experiences of G2, and the characteristics of households and families into which G3 are born, as well as collecting saliva samples from the G3 children and their non-FF parents and stool samples from the G3 children; we refer to this project as the FFG3 study. The augmented data will have many unique and valuable features, including: (1) three generations of sociodemographic, environmental, and biological data; (2) extensive data on parenting in two generations (G1 and G2); (3) data on siblings and half-siblings (in G3); (4) genetic data on trios (G3 children and both of their parents); and (5) comprehensive data on perinatal health (pre-pregnancy, prenatal, delivery, neonatal, and postpartum factors) and circumstances in two generations (G2 & G3). The FFG3 study will facilitate novel and important analyses of intergenerational transmission of health, intergenerational relationships within families, and gene*environment effects on health. It will also provide an essential foundation for future G3 data collection at subsequent developmental transitions including school readiness at the transition to school, and health and development in middle childhood, adolescence, and the transition to adulthood.

摘要 健康状况不佳和贫困的代际持续以及对潜在原因的探索 这些过程强调了丰富的多代数据的重要性。很少有现有数据集包含 关于生命过程中的社会、环境和生物因素的全面信息 这种数据的缺乏限制了确定形成健康差距的过程的努力， 经济不平等，以及两者之间的因果联系。脆弱家庭与儿童福祉研究 (FF)是美国持续时间最长的基于全国概率样本的出生队列研究。它 跟踪父母(G1，第一代)-母亲和父亲-以及他们的孩子(G2)，他们出生于 1998-2000年。G2的孩子们现在也有了自己的孩子。我们建议通过以下方式扩展森林论坛研究 对第三代(G3)儿童进行围产期健康调查，早期为人父母的经历 以及G3出生的家庭和家庭的特征，以及收集唾液 来自三国儿童及其非儿童家长的样本和来自三国儿童的粪便样本；我们参考 该项目作为FFG3研究。增强后的数据将具有许多独特而有价值的功能，包括： (1)三代人的社会人口、环境和生物数据；(2)关于育儿的广泛数据 两代(G1和G2)；(3)兄弟姐妹和同父异母兄弟姐妹的数据(G3)；(4)关于三人组的遗传数据(G3 儿童及其父母)；和(5)关于围产期健康的综合数据(孕前、产前、 分娩、新生儿和产后因素)和两代人(G2和G3)的情况。FFG3研究 将促进健康代际传递的新的和重要的分析，代际 家庭关系和基因*环境对健康的影响。它还将提供必要的 为未来G3在后续发展过渡阶段收集数据奠定基础，包括在 学龄儿童中期、青春期和过渡到 成人期。