COBRE Phase III: Delaware Center for Neuroscience Research

COBRE III 期：特拉华神经科学研究中心

• 批准号: 10424999
• 负责人: MELISSA A HARRINGTON
• 金额: $ 114.61万
• 依托单位: DELAWARE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10424999
• 关键词: Animals; Applications Grants; Award; Basic Science; Behavior; Biomedical Research; Brain; Brain imaging; Caliber; Cells; Centers of Research Excellence; Cognition; Collaborations; Communities; Core Facility; Data; Delaware; Development; Disease; Education; Electrodes; Electrophysiology (science); Ensure; Environment; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Faculty; Faculty Recruitment; Feeling; Fostering; Foundations; Funding; Genetic; Goals; Grant; Historically Black Colleges and Universities; Human; Human Resources; Image; Infrastructure; Injury; Institution; Invertebrates; Investments; Lead; Longevity; Magnetic Resonance Imaging; Memory; Mentored Research Scientist Development Award; Mentors; Minority; Modeling; Molecular; Nervous System Physiology; Neurosciences; Neurosciences Research; Phase; Physiology; Pilot Projects; Program Development; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Rodent Model; Services; Slice; Structure; Structure-Activity Relationship; Study Section; Thinking; Time; Tissues; Training; Training Activity; Translational Research; United States National Institutes of Health; Universities; Vocational Guidance; base; biomedical imaging; career; diversity and equity; experience; faculty research; human subject; improved; innovation; insight; inter-institutional; meetings; member; neuroimaging; non-invasive imaging; operation; patch clamp; programs; public health relevance; relating to nervous system; research data dissemination; skills; success; symposium; undergraduate student

Overall Proposal Summary The Delaware Center for Neuroscience Research, established in 2012 with a COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD). Our unique Center brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and the state’s flagship research university (UD). Phase II of our Neuroscience Center COBRE was focused strengthening our infrastructure for neuroscience research, and to continue to support the research and professional development of early stage investigators that included Project Leads, Pilot Grant PIs, and new faculty who were hired at DSU with COBRE support. Our Center has been very successful with over 175 publications by COBRE-supported researchers, six Project Leads “graduated” into R01 support, three pilot investigator graduated to NSF grants including a CAREER award, and new faculty recruited to DSU with COBRE support winning K01 and R21 awards. During Phase II our institutions made significant investments in the research infrastructure for neuroscience. The University of Delaware established the Center for Biomedical and Brain Imaging with a 3T scanner for human magnetic resonance imaging, and a 9.4T scanner with small bore magnet for MRI with rodent models. Delaware State University established a Cell Electrophysiology Core facility to provide patch clamp, multi-electrode and automated patch clamp services with cells and tissue slices to help neuroscience investigators answer their research questions. Our phase III project will strengthen both our Center and neuroscience research in Delaware by transitioning the core resources and biomedical research activities our Neuroscience Center into independence and sustainability. The overarching scientific goal of our Neuroscience Center is to bring together and support neuroscientists working at multiple scales, from human subjects to rodent and invertebrate models to improve our understanding of the dynamic function of the brain. During Phase III we will pursue three specific aims for our Center: 1) involving a new group of investigators in the Center’s integrated mentoring and professional development program with a pilot grant program that will help junior faculty become independent, externally-funded researchers; 2) strengthening the research infrastructure and capacity in Delaware by supporting our research core facilities to transition to sustainability; and 3) to develop the Delaware Center for Neuroscience Research as a supportive, sustainable scientific community focused on investigating dynamic structure-function relationships in the brain. Continuing this COBRE program will have two significant long-term benefits. First, we will build on our success to support more Delaware neuroscientists to achieve NIH funding for their research on understanding the brain. Second, as the only COBRE based at an Historically-Black institution, our project has a uniquely significant impact in supporting diversity, equity and inclusion in the IDeA program and biomedical research in general.

总体建议书 摘要 特拉华州神经科学研究中心成立于2012年，拥有 科布尔奖是特拉华州立大学(DSU)和 特拉华大学(UD)。我们独特的中心汇聚了教职员工和研究人员 资源来自两个非常不同的机构：一个为少数群体服务的本科生 在神经科学研究(DSU)方面具有新兴实力的大学，以及州立大学 旗舰研究大学(UD)。我们的神经科学中心Cobre的第二阶段专注于加强我们的 为神经科学研究提供基础设施，并继续支持早期研究和专业发展 阶段调查人员，包括项目负责人、飞行员资助人和与Cobre一起在DSU招聘的新教员 支持。我们的中心非常成功，发表了超过175篇由科布雷支持的研究人员，Six Project 带领毕业生进入R01支持，三名试点调查员毕业于NSF补助金，包括一项职业奖项，以及 在科布雷的支持下，新入职的教员获得了K01和R21奖项。 在第二阶段，我们的机构在神经科学的研究基础设施上进行了重大投资。 特拉华大学建立了生物医学和脑成像中心，为人类安装了3T扫描仪 磁共振成像和9.4T小口径磁体扫描仪，用于啮齿动物模型的磁共振成像。特拉华州 大学建立了细胞电生理学核心设施，提供膜片钳、多电极和自动化 膜片钳为细胞和组织切片提供服务，帮助神经科学研究人员回答他们的研究问题。 我们的第三阶段项目将通过过渡核心来加强我们在特拉华州的中心和神经科学研究 资源和生物医学研究活动使我们的神经科学中心走向独立和可持续发展。 我们神经科学中心的首要科学目标是汇聚和支持神经科学家 在多个尺度上工作，从人类受试者到啮齿动物和无脊椎动物模型，以提高我们对 大脑的动态功能。在第三阶段，我们将为我们的中心实现三个具体目标：1)涉及 中心综合指导和职业发展计划中的新调查组，并有一名试点 助学金计划，帮助初级教员成为独立的、外部资助的研究人员；2)加强 通过支持我们的研究核心设施向可持续发展过渡，在特拉华州的研究基础设施和能力； 以及3)将特拉华州神经科学研究中心发展为一个支持性、可持续的科学社区 专注于研究大脑中动态的结构-功能关系。 继续这项Cobre计划将有两个重要的长期好处。首先，我们将在我们的 成功地支持更多的特拉华州神经科学家获得NIH的资金，用于他们了解大脑的研究。 其次，作为唯一位于历史悠久的黑人机构的Cobre，我们的项目在 支持多样性、公平性和包容性，广泛参与IDEA计划和生物医学研究。