COBRE Phase III: Delaware Center for Neuroscience Research

COBRE III 期：特拉华神经科学研究中心

• 批准号: 10424999
• 负责人: MELISSA A HARRINGTON
• 金额: $ 114.61万
• 依托单位: DELAWARE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10424999
• 关键词: Animals; Applications Grants; Award; Basic Science; Behavior; Biomedical Research; Brain; Brain imaging; Caliber; Cells; Centers of Research Excellence; Cognition; Collaborations; Communities; Core Facility; Data; Delaware; Development; Disease; Education; Electrodes; Electrophysiology (science); Ensure; Environment; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Faculty; Faculty Recruitment; Feeling; Fostering; Foundations; Funding; Genetic; Goals; Grant; Historically Black Colleges and Universities; Human; Human Resources; Image; Infrastructure; Injury; Institution; Invertebrates; Investments; Lead; Longevity; Magnetic Resonance Imaging; Memory; Mentored Research Scientist Development Award; Mentors; Minority; Modeling; Molecular; Nervous System Physiology; Neurosciences; Neurosciences Research; Phase; Physiology; Pilot Projects; Program Development; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Rodent Model; Services; Slice; Structure; Structure-Activity Relationship; Study Section; Thinking; Time; Tissues; Training; Training Activity; Translational Research; United States National Institutes of Health; Universities; Vocational Guidance; base; biomedical imaging; career; diversity and equity; experience; faculty research; human subject; improved; innovation; insight; inter-institutional; meetings; member; neuroimaging; non-invasive imaging; operation; patch clamp; programs; public health relevance; relating to nervous system; research data dissemination; skills; success; symposium; undergraduate student

Overall Proposal Summary The Delaware Center for Neuroscience Research, established in 2012 with a COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD). Our unique Center brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and the state’s flagship research university (UD). Phase II of our Neuroscience Center COBRE was focused strengthening our infrastructure for neuroscience research, and to continue to support the research and professional development of early stage investigators that included Project Leads, Pilot Grant PIs, and new faculty who were hired at DSU with COBRE support. Our Center has been very successful with over 175 publications by COBRE-supported researchers, six Project Leads “graduated” into R01 support, three pilot investigator graduated to NSF grants including a CAREER award, and new faculty recruited to DSU with COBRE support winning K01 and R21 awards. During Phase II our institutions made significant investments in the research infrastructure for neuroscience. The University of Delaware established the Center for Biomedical and Brain Imaging with a 3T scanner for human magnetic resonance imaging, and a 9.4T scanner with small bore magnet for MRI with rodent models. Delaware State University established a Cell Electrophysiology Core facility to provide patch clamp, multi-electrode and automated patch clamp services with cells and tissue slices to help neuroscience investigators answer their research questions. Our phase III project will strengthen both our Center and neuroscience research in Delaware by transitioning the core resources and biomedical research activities our Neuroscience Center into independence and sustainability. The overarching scientific goal of our Neuroscience Center is to bring together and support neuroscientists working at multiple scales, from human subjects to rodent and invertebrate models to improve our understanding of the dynamic function of the brain. During Phase III we will pursue three specific aims for our Center: 1) involving a new group of investigators in the Center’s integrated mentoring and professional development program with a pilot grant program that will help junior faculty become independent, externally-funded researchers; 2) strengthening the research infrastructure and capacity in Delaware by supporting our research core facilities to transition to sustainability; and 3) to develop the Delaware Center for Neuroscience Research as a supportive, sustainable scientific community focused on investigating dynamic structure-function relationships in the brain. Continuing this COBRE program will have two significant long-term benefits. First, we will build on our success to support more Delaware neuroscientists to achieve NIH funding for their research on understanding the brain. Second, as the only COBRE based at an Historically-Black institution, our project has a uniquely significant impact in supporting diversity, equity and inclusion in the IDeA program and biomedical research in general.

报价总额 总结 特拉华州神经科学研究中心成立于2012年， COBRE奖，是特拉华州州立大学（DSU）和 特拉华州大学（UD）。我们独特的中心汇集了教师和研究 资源来自两个非常不同的机构：少数服务，本科 一所在神经科学研究（DSU）方面具有新兴实力的大学，以及该州的 旗舰研究型大学（UD）。我们神经科学中心的第二阶段COBRE专注于加强我们的 神经科学研究的基础设施，并继续支持早期的研究和专业发展 阶段调查人员，包括项目负责人，试点赠款PI，和新的教师谁是在DSU与COBRE雇用 支持.我们的中心非常成功，由COBRE-supported研究人员发表了175多篇论文， 领导“毕业”到R 01支持，三名试点研究员毕业到NSF赠款，包括职业奖， 在COBRE的支持下，DSU招募了新的教师，赢得了K 01和R21奖项。 在第二阶段，我们的机构对神经科学的研究基础设施进行了重大投资。 特拉华州大学建立了生物医学和脑成像中心，该中心配备了3 T扫描仪， 磁共振成像，和9.4T扫描仪与小口径磁铁MRI与啮齿动物模型。特拉华州 大学建立了细胞电生理核心设施，提供膜片钳，多电极和自动化 膜片钳服务与细胞和组织切片，以帮助神经科学研究人员回答他们的研究问题。 我们的第三阶段项目将加强我们的中心和特拉华州的神经科学研究， 资源和生物医学研究活动，我们的神经科学中心的独立性和可持续性。 我们神经科学中心的首要科学目标是汇集和支持神经科学家 在多个尺度上工作，从人类受试者到啮齿动物和无脊椎动物模型，以提高我们对 大脑的动态功能。在第三阶段，我们将追求我们中心的三个具体目标：1）涉及 该中心的综合辅导和专业发展计划中的一个新的调查小组， 资助计划，这将有助于初级教师成为独立的，外部资助的研究人员; 2）加强 研究基础设施和能力在特拉华州通过支持我们的研究核心设施过渡到可持续发展; 以及3）将特拉华州神经科学研究中心发展成为一个支持性的、可持续的科学团体 专注于研究大脑中的动态结构-功能关系。 继续执行COBRE计划将有两个重大的长期好处。首先，我们将建立在我们的 成功地支持更多的特拉华州神经科学家，以实现国家卫生研究院资助他们的研究了解大脑。 第二，作为唯一一个总部设在历史上的黑人机构的COBRE，我们的项目在以下方面具有独特的重大影响： 支持IDEA计划和生物医学研究的多样性，公平性和包容性。