Amygdala Encoding of Reward Memory
奖励记忆的杏仁核编码
基本信息
- 批准号:10312687
- 负责人:
- 金额:$ 6.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Amygdaloid structureBasic ScienceBehaviorBehavioralBehavioral AssayBehavioral MechanismsCalciumCannabisCellsChoice BehaviorCoupledCuesDataDecision MakingDesire for foodDiseaseDrug TargetingEmotionalEnvironmentEventFoundationsFutureGenetic RecombinationGoalsImageImmunohistochemistryIndividualInterventionLearningLifeLiteratureMemoryMentorsMicroscopeMusNeurobiologyNeuronsNeurosciencesOpioidOutcomePatternPopulationProcessPsyche structureResearchResolutionRewardsRoleRunningSensorySiteStimulusSubstance Use DisorderSupport SystemSystemTestingTrainingTransgenic MiceWorkaddictionapproach behavioravoidance behaviorbasecareerclassical conditioningdesigndrug of abuseexperienceexperimental studyin vivoin vivo calcium imaginginsightminiaturizeneural circuitneuromechanismneuropsychiatrynoveloptogeneticsrelating to nervous systemresponsesimulationtheoriestooltreatment strategy
项目摘要
To made adaptive goal-directed choices, we have to consider the consequences of our actions so we can select
the most advantageous choice. These considerations are informed by our memory of similar circumstances in
the past. This capacity becomes disrupted in many neuropsychiatric conditions including substance use
disorder. One behavioral mechanism by which adaptive decisions are made is via stimulus-reward
associations. Despite the importance of understanding both adaptive and maladaptive decision making, we
know very little about the neural circuits that encode these stimulus-reward memories. As such, the general
goal of this project is to evaluate the neural mechanisms that underlie stimulus-reward memories and how they
influence decision making. This work will provide insight into a vital aspect of motivated decision making, setting
a foundation for understanding how these processes may go awry in disease states, and ultimately inform
treatment strategies.
A burgeoning literature indicates that memories can be encoded in discrete neural ensembles. These
populations of cells have also been identified in the basolateral amygdala, a neural region that is also essential
to the encoding and retrieving of reward memories. However, our understanding of whether and how ensembles
of cells in the basolateral amygdala represent unique rewards, cues, and subsequently guide decisions is
incomplete. My proposed study will determine whether there are unique reward and cue representing cells in
the basolateral amygdala and how they may promote choice behavior. To accomplish these goals I will use a
combination of cutting edge neuroscience tools and sophisticated behavioral assays in mice. In Aim 1, I will
utilize a novel tag and capture approach to manipulate reward and cue activated neurons in the basolateral
amygdala to determine the causal contribution of these neural ensembles to decision making. In Aim 2, I will
use in vivo cellular resolution calcium imaging via miniaturized microscopes to reveal the neural dynamics of
the basolateral amygdala in response to rewards and their affiliative cues, and during decisions. The outcomes
of these proposed experiments will provide crucial information for our understanding of how the basolateral
amygdala contributes to reward motivated choice. These findings will also provide insight for how the
basolateral amygdala might be a target for drugs of abuse, but also may also serve as a site for intervention
and treatment. I will carry out these studies in the Wassum Lab at UCLA, with the support and direction of a
diverse and well-rounded mentoring team. The environment at UCLA will also provide excellent intellectual,
technical and professional training. This will leave me well equipped to achieve my career goals of running an
independent research lab studying addiction neurobiology.
为了做出适应性目标导向的选择,我们必须考虑我们行动的后果,以便我们可以选择
最有利的选择。这些考虑是基于我们对类似情况的记忆
过去。这种能力在许多神经精神疾病(包括物质使用)中受到破坏
紊乱。做出适应性决策的一种行为机制是通过刺激奖励
协会。尽管理解适应性和适应不良决策很重要,但我们
我们对编码这些刺激奖励记忆的神经回路知之甚少。因此,一般
该项目的目标是评估刺激奖励记忆背后的神经机制以及它们如何
影响决策。这项工作将深入了解动机性决策的一个重要方面,设置
为了解这些过程在疾病状态下如何出错并最终提供信息奠定了基础
治疗策略。
新兴的文献表明记忆可以被编码在离散的神经元集合中。这些
在基底外侧杏仁核中也发现了细胞群,基底外侧杏仁核也是一个重要的神经区域
奖励记忆的编码和检索。然而,我们对是否以及如何集成的理解
基底外侧杏仁核中的细胞代表独特的奖励、线索,并随后指导决策
不完整。我提出的研究将确定是否存在代表细胞的独特奖励和提示
基底外侧杏仁核及其如何促进选择行为。为了实现这些目标,我将使用
尖端神经科学工具和复杂的小鼠行为分析的结合。在目标 1 中,我将
利用新颖的标签和捕获方法来操纵基底外侧的奖励和提示激活神经元
杏仁核来确定这些神经元对决策的因果贡献。在目标 2 中,我将
通过微型显微镜使用体内细胞分辨率钙成像来揭示神经动力学
基底外侧杏仁核对奖励及其附属线索以及决策过程做出反应。结果
这些拟议的实验将为我们理解基底外侧如何
杏仁核有助于奖励动机选择。这些发现也将为我们如何
基底外侧杏仁核可能是滥用药物的目标,但也可能作为干预部位
和治疗。我将在加州大学洛杉矶分校的 Wassum 实验室进行这些研究,并得到以下人士的支持和指导:
多元化且全面的指导团队。加州大学洛杉矶分校的环境也将提供优秀的智力、
技术和专业培训。这将使我有能力实现经营一家公司的职业目标
研究成瘾神经生物学的独立研究实验室。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Baila Sara Hall其他文献
Baila Sara Hall的其他文献
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