RAATE COVID Supplement

RAATE 新冠肺炎补充

• 批准号: 10308882
• 负责人: OWEN T. CARMICHAEL
• 金额: $ 32.07万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10308882
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adult; African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Awareness; Behavior Therapy; Belief; Biomedical Research; COVID-19; COVID-19 mortality; COVID-19 pandemic; Catchment Area; Cessation of life; Characteristics; Cities; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Contracts; Country; Data; Deep South; Diet Habits; Dietary Practices; Disease; Elderly; Enrollment; Epidemiology; Ethnic group; Exercise; Exposure to; Familiarity; Fright; Funding; General Population; Geography; Goals; Health; High Prevalence; Hospitalization; Individual; Infection; Institution; Intervention; Intubation; Knowledge; Life Style; Life Style Modification; Louisiana; Medical; Modeling; Moods; North Carolina; Outcome; Output; Participant; Pattern; Personal Satisfaction; Persons; Physical activity; Population; Predisposition; Prevalence; Prevention strategy; Procedures; Public Health; Questionnaires; Reporting; Research; Research Methodology; Research Personnel; Rest; Risk; Risk Factors; Sampling; Scientist; Severities; Social Distance; Social isolation; Source; Surveys; Techniques; Teleconferences; Terminology; Transportation; Trust; Universities; Vaccines; aging population; caucasian American; cohort; coronavirus disease; design; distrust; ethnic minority population; health belief; health care availability; health disparity; high risk; improved; infection risk; interest; lifestyle factors; member; mortality; multidisciplinary; novel; novel strategies; pandemic disease; parent grant; patient-clinician communication; psychologic; racial difference; racial disparity; recruit; research study; sedentary; social; viral transmission; volunteer; willingness

Project summary The Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) study is funded to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will recruit 200 older African American adults. The study is important because African American adults are broadly underrepresented in Alzheimer's Disease and Related Disorders (ADRD) research, leading to limited knowledge of disparities in ADRD causes, preventive strategies, and clinical course of ADRD. One specific area of ADRD research with especially critical under-representation is lifestyle modification as a preventive strategy. The COVID-19 pandemic has the potential to significantly hamper efforts to recruit African American into clinical trials, such as the RAATE study. African Americans are at increased risk of infection, hospitalization, and death from COVID compared to members of other ethnic groups, and this may reduce willingness to participate in clinical trials given the need for in-person assessments and intervention sessions. Our study, Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) COVID 19 administrative supplement is designed to determine the impact of COVID-19 on older African Americans' willingness to participate in research. We will form an integrated multidisciplinary team of scientists in aging research, health disparities, and epidemiology to address this issue in an area representative of the Deep South, Baton Rouge, Louisiana. This region of the country has been particularly impacted by COVID-19. In collaboration with investigators from University of North Carolina and using the Health Belief Model as a theoretical framework, we will develop a questionnaire to assess the impact of COVID-19 on participant's lifestyle, perceived susceptibility and severity to COVID, benefits and barriers to research participation, access to healthcare, and trust in information sources. Aim 1 will assess Covid-19- related changes to the health and well-being of older African Americans. Aim 2 will assess Covid-19-related knowledge and willingness to participate in research among older African Americans. The final output of the RAATE-COVID supplement study will be to enhance enrollment in the RAATE study and to develop a set of generalizable strategies for recruiting sedentary older African Americans into clinical studies of lifestyle factors in aging.

项目总结 通过锻炼降低非裔美国人阿尔茨海默氏症风险研究(RAATE)得到资助，以 确定体力活动对老年非裔美国人阿尔茨海默病危险因素的影响 成年人。这项研究将招募200名年长的非洲裔美国人。这项研究很重要，因为非洲 美国成年人在阿尔茨海默病和相关疾病(ADRD)中的比例普遍偏低 研究导致对ADRD病因、预防策略和临床病程的差异认识有限 是ADRD的。ADRD研究的一个特别重要的领域是生活方式 将修改作为一种预防策略。新冠肺炎大流行有可能严重阻碍这一努力 招募非裔美国人进行临床试验，例如RAATE研究。非洲裔美国人的人数增加了 与其他种族的成员相比，感染、住院和死亡的风险，这 可能会降低参与临床试验的意愿，因为需要面对面的评估和 干预会议。我们的研究，通过以下途径降低非裔美国人患阿尔茨海默病的风险 演习(RAATE)COVID 19行政补充旨在确定新冠肺炎的影响 关于年长的非裔美国人参与研究的意愿。我们将形成一个综合的多学科 研究老龄化、健康差异和流行病学的科学家团队，在一个领域解决这一问题 路易斯安那州巴吞鲁日的南方腹地代表。该国的这一地区一直特别 受新冠肺炎影响。与北卡罗来纳大学的研究人员合作，并使用 以健康信念模型为理论框架，我们将编制一份调查问卷来评估影响 新冠肺炎关于参与者的生活方式、感知的COVID易感性和严重性、优势和障碍 参与研究、获得医疗保健以及对信息来源的信任。AIM 1将评估新冠肺炎- 与老年非裔美国人的健康和福祉相关的变化。AIM 2将评估与新冠肺炎相关的 老年非裔美国人参与研究的知识和意愿。的最终输出 RAATE-COVID补充研究将提高RAATE研究的招生人数，并制定一套 将久坐不动的老年非裔美国人招募到生活方式因素的临床研究中的普遍策略 在衰老过程中。