RAATE COVID Supplement

RAATE 新冠肺炎补充

• 批准号: 10308882
• 负责人: OWEN T. CARMICHAEL
• 金额: $ 32.07万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10308882
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adult; African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Awareness; Behavior Therapy; Belief; Biomedical Research; COVID-19; COVID-19 mortality; COVID-19 pandemic; Catchment Area; Cessation of life; Characteristics; Cities; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Contracts; Country; Data; Deep South; Diet Habits; Dietary Practices; Disease; Elderly; Enrollment; Epidemiology; Ethnic group; Exercise; Exposure to; Familiarity; Fright; Funding; General Population; Geography; Goals; Health; High Prevalence; Hospitalization; Individual; Infection; Institution; Intervention; Intubation; Knowledge; Life Style; Life Style Modification; Louisiana; Medical; Modeling; Moods; North Carolina; Outcome; Output; Participant; Pattern; Personal Satisfaction; Persons; Physical activity; Population; Predisposition; Prevalence; Prevention strategy; Procedures; Public Health; Questionnaires; Reporting; Research; Research Methodology; Research Personnel; Rest; Risk; Risk Factors; Sampling; Scientist; Severities; Social Distance; Social isolation; Source; Surveys; Techniques; Teleconferences; Terminology; Transportation; Trust; Universities; Vaccines; aging population; caucasian American; cohort; coronavirus disease; design; distrust; ethnic minority population; health belief; health care availability; health disparity; high risk; improved; infection risk; interest; lifestyle factors; member; mortality; multidisciplinary; novel; novel strategies; pandemic disease; parent grant; patient-clinician communication; psychologic; racial difference; racial disparity; recruit; research study; sedentary; social; viral transmission; volunteer; willingness

Project summary The Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) study is funded to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will recruit 200 older African American adults. The study is important because African American adults are broadly underrepresented in Alzheimer's Disease and Related Disorders (ADRD) research, leading to limited knowledge of disparities in ADRD causes, preventive strategies, and clinical course of ADRD. One specific area of ADRD research with especially critical under-representation is lifestyle modification as a preventive strategy. The COVID-19 pandemic has the potential to significantly hamper efforts to recruit African American into clinical trials, such as the RAATE study. African Americans are at increased risk of infection, hospitalization, and death from COVID compared to members of other ethnic groups, and this may reduce willingness to participate in clinical trials given the need for in-person assessments and intervention sessions. Our study, Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE) COVID 19 administrative supplement is designed to determine the impact of COVID-19 on older African Americans' willingness to participate in research. We will form an integrated multidisciplinary team of scientists in aging research, health disparities, and epidemiology to address this issue in an area representative of the Deep South, Baton Rouge, Louisiana. This region of the country has been particularly impacted by COVID-19. In collaboration with investigators from University of North Carolina and using the Health Belief Model as a theoretical framework, we will develop a questionnaire to assess the impact of COVID-19 on participant's lifestyle, perceived susceptibility and severity to COVID, benefits and barriers to research participation, access to healthcare, and trust in information sources. Aim 1 will assess Covid-19- related changes to the health and well-being of older African Americans. Aim 2 will assess Covid-19-related knowledge and willingness to participate in research among older African Americans. The final output of the RAATE-COVID supplement study will be to enhance enrollment in the RAATE study and to develop a set of generalizable strategies for recruiting sedentary older African Americans into clinical studies of lifestyle factors in aging.

项目摘要 通过运动降低非裔美国人阿尔茨海默病风险（RAATE）研究的资助， 确定身体活动对老年非裔美国人阿尔茨海默病风险因素的影响 成年人了这项研究将招募200名老年非裔美国人。这项研究很重要，因为非洲 美国成年人在阿尔茨海默病和相关疾病（ADRD）中的代表性普遍不足 研究，导致对ADRD原因，预防策略和临床过程的差异了解有限 的ADRD。ADRD研究的一个特别重要的代表性不足的具体领域是生活方式 作为一种预防性战略。2019冠状病毒病大流行有可能严重阻碍 招募非裔美国人参加临床试验，如RAATE研究。非裔美国人在增加 与其他种族群体相比，感染、住院和死于COVID的风险更高， 考虑到需要亲自评估，可能会降低参与临床试验的意愿， 干预会议。我们的研究，通过降低非裔美国人的阿尔茨海默病风险 2019冠状病毒病行政补充演习（RAATE）旨在确定2019冠状病毒病的影响 老年非裔美国人参与研究的意愿我们将形成一个综合的多学科 一组科学家在老龄化研究，健康差距，流行病学，以解决这一问题的一个地区 路易斯安那州巴吞鲁日的南方腹地的代表。该国的这一地区特别 受到COVID-19的影响。与来自北卡罗来纳州的研究人员合作， 以健康信念模式为理论框架，我们将编制一份问卷，以评估 COVID-19对参与者的生活方式、对COVID的易感性和严重程度、 参与研究、获得医疗保健和信任信息来源。目标1将评估新冠肺炎- 与老年非裔美国人的健康和福祉相关的变化。目标2将评估与新冠肺炎相关的 知识和意愿参与研究中老年非裔美国人。的最终输出 RAATE-COVID补充研究将提高RAATE研究的入组率，并制定一套 招募久坐的老年非裔美国人参与生活方式因素临床研究的可推广策略 在衰老。