Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy

通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应

基本信息

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Project Summary Reduced skeletal muscle mitochondrial oxidative capacity of skeletal muscle has been implicated in aging- related declines in cardiorespiratory fitness, physical functioning, and cardiometabolic health. Although exercise training in older adults increases mitochondrial capacity, virtually all of the data is reported in terms of average responses within groups. Yet within groups, there is enormous inter-individual variation in these responses. Two specific questions remain regarding the significance and implications of exercise-induced changes in mitochondrial capacity. 1) Does exercise improve mitochondrial capacity similarly in older and younger adults? 2) What are the molecular signatures within skeletal muscle that associate with improvements in mitochondrial capacity in older and younger adults? We will address these major gaps in knowledge by objectively assessing the spectrum of mitochondrial capacity responses to exercise in vivo, investigating the underlying molecular regulation of exercise responses, and relating the mitochondrial responses and molecular factors to clinically-relevant outcomes such as exercise-induced improvements in cardiorespiratory fitness (VO2max). The NIH-funded Molecular Transducers of Physical Activity Consortium (MoTrPAC) funds collection of comprehensive molecular signatures from biospecimens before and after 12 weeks of aerobic and resistance exercise training in healthy adults spanning the adult age span. This ancillary study will synergize with MoTrPAC and will add measurements of mitochondrial capacity of the skeletal muscle via non-invasive 31P magnetic resonance spectroscopy (31P-MRS) before and after training in 420 individuals across a wide age range (18 to 60+). Aim 1 is to assess differences in the mitochondrial capacity response to exercise training across the agespan and between aerobic and resistance training. Aim 2 is to identify molecular transducers of mitochondrial capacity induced by exercise. Primary hypotheses are that a proportion of individuals will not improve mitochondrial capacity following exercise training regardless of modality; age per se will not correlate with mitochondrial capacity responses; that greater improvements in mitochondrial capacity will associate similarly with greater improvements in cardiorespiratory fitness in younger and older adults; and that mitochondrial capacity responses will be greater with aerobic training compared to resistance training but aerobic-resistance differences will be similar across age groups. The impact of the project is that it will leverage the high-throughput `omics' technologies and exercise studies provided by MoTrPAC to shed light on mechanisms underlying the variation in mitochondrial capacity responses linked to health benefits of physical activity in older adults. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page
项目主管/首席研究员(后、一、中):

项目成果

期刊论文数量(0)
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OWEN T. CARMICHAEL其他文献

OWEN T. CARMICHAEL的其他文献

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{{ truncateString('OWEN T. CARMICHAEL', 18)}}的其他基金

Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy
通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应
  • 批准号:
    10676163
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy - sIRB supplment
通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应 - sIRB 补充
  • 批准号:
    10469919
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy - sIRB supplement
通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应 - sIRB 补充
  • 批准号:
    10664675
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)
通过运动降低非裔美国人阿尔茨海默病风险 - MCI 队列 (RAATE-MCI)
  • 批准号:
    10393635
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy
通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应
  • 批准号:
    10241533
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)
通过运动降低非裔美国人阿尔茨海默病风险 - MCI 队列 (RAATE-MCI)
  • 批准号:
    10196930
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
Aging and the mitochondrial response to exercise training, measured by noninvasive 31P magnetic resonance spectroscopy
通过无创 31P 磁共振波谱测量衰老和线粒体对运动训练的反应
  • 批准号:
    10417265
  • 财政年份:
    2020
  • 资助金额:
    $ 3.25万
  • 项目类别:
RAATE COVID Supplement
RAATE 新冠肺炎补充
  • 批准号:
    10308882
  • 财政年份:
    2019
  • 资助金额:
    $ 3.25万
  • 项目类别:
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"
“大规模衰老研究中的MR形态计量学和认知下降率”
  • 批准号:
    7469728
  • 财政年份:
    2008
  • 资助金额:
    $ 3.25万
  • 项目类别:
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"
“大规模衰老研究中的 MR 形态计量学和认知下降率”
  • 批准号:
    8292019
  • 财政年份:
    2008
  • 资助金额:
    $ 3.25万
  • 项目类别:

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