权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)

通过运动降低非裔美国人阿尔茨海默病风险 - MCI 队列 (RAATE-MCI)

基本信息

批准号：
10393635
负责人：
OWEN T. CARMICHAEL
金额：
$ 93.46万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10393635
关键词：
Address Adult African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid Anti-Inflammatory Agents Biological Biological Assay Biological Markers Blood Blood Vessels Brain Brain-Derived Neurotrophic Factor Cardiovascular system Cerebrovascular Circulation Cerebrum Characteristics Chromosomes Chronic Clinical Cognitive Communities Control Groups Data Dementia Development Diagnosis Diet Education Effectiveness Elderly Episodic memory Ethnic Population Evaluation Exclusion Exercise Exposure to Functional Magnetic Resonance Imaging Genotype Hormones Impaired cognition Impairment Individual Insulin-Like Growth Factor I Intervention Ischemia Knowledge Length Leukocytes Longevity Magnetic Resonance Imaging Measurement Measures Mediating Memory Memory Loss Mental Depression National Institute on Alcohol Abuse and Alcoholism Nerve Degeneration Neurobiology Not Hispanic or Latino Other Genetics Outcome Participant Pathway interactions Patients Perfusion Phenotype Physical activity Physiological Population Positron-Emission Tomography Prevalence Public Health Randomized Randomized, Controlled Trials Recommendation Research Risk Risk Factors Risk Reduction Sample Size Sleep Structure Time Underserved Population White Matter Hyperintensity active control group brain tissue cardiorespiratory fitness cardiovascular risk factor caucasian American cerebrovascular clinical phenotype cognitive benefits cognitive enhancement cognitive function cohort comparison control depressive symptoms evidence base executive function exercise intervention experience fitness functional disability genetic risk factor gray matter health disparity improved insight mild cognitive impairment neuroimaging neuromechanism neuroprotection neuropsychiatry neurotrophic factor preservation prevent programs progression risk randomized, clinical trials recruit response sex symptomatology telomere trial design β-amyloid burden

项目摘要

Project Summary Alzheimer’s disease is steadily increasing in prevalence, with a devastating public health impact. The prevalence of Alzheimer’s Disease is higher in African Americans compared to white Americans, thereby constituting a health disparity. Individuals with mild cognitive impairment (MCI) are at increased risk for progressing to dementia, including AD dementia. Interventions that prevent Alzheimer’s disease or change the course of cognitive decline associated with Alzheimer’s disease are needed. Most older adults do not achieve recommended levels of physical activity, and this includes African Americans. Regular physical activity has proven to be a safe and effective means to enhance cognitive function in older adults with MCI. Therefore, our study is focused on physical activity promotion, a potent approach to modifying multiple neurobiological pathways implicated in Alzheimer’s Disease. We evaluate exercise benefits among elderly African Americans, who are understudied and in whom the natural course of neurodegeneration, exercise effects on neuroprotection and neurodegeneration, and resulting clinical phenotypes may differ. A large body of existing data suggests that exercise improves cardiovascular and cerebrovascular functioning, and thus has the potential to enhance perivascular clearance of amyloid and reduce chronic brain tissue ischemia, among other beneficial effects. At the same time, chronic exercise has been shown to increase central levels of neurotrophic factors, which in turn promote protection against Alzheimer’s Disease neurodegeneration pathways via a variety of mechanisms. While physical activity interventions have been shown to have positive effects on these factors and on resultant cognitive functioning in older adults, nearly all interventions have had a negligible representation of African Americans. Prior data suggests that African Americans enter their elderly years against a backdrop of different lifespan exposures to a variety of factors relevant to neuroprotection and neurodegeneration, including cardiovascular risk, exercise, diet, and education. In addition, prior data suggests that the key genetic risk factor for Alzheimer’s Disease (APOE) may have differing consequences for Alzheimer’s Disease risk among African Americans, and other genetic differences (i.e. leucocyte telomere length) have the potential to influence the brain benefits of physical activity in this community. We will utilize a randomized clinical trial to addresses these questions. Participants will be randomized into a physical activity promotion intervention or an active control group for 52 weeks. We will recruit a population with MCI. We will assess cognitive function, brain structure and function, circulating hormones, neurotrophic factors, objectively measured physical activity, cardiorespiratory fitness, sleep parameters, and telomere length. Our study will take the first step toward understanding whether the hypothesized benefits of exercise for the brain carry over to elderly African Americans with MCI.

项目总结