Implicit Structural Priming as a Treatment Component in Aphasia

内隐结构启动作为失语症的治疗组成部分

• 批准号: 10445227
• 负责人: Jiyeon Lee
• 金额: $ 65.84万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445227
• 关键词: Affect; Aphasia; Assessment tool; Clinical; Communication; Comprehension; Data; Development; Eye; Goals; Heart; Impairment; Intervention; Language; Language Development; Learning; Linguistics; Maintenance; Measures; Modality; Modeling; Outcome; Outcome Measure; Participant; Persons; Phase; Process; Production; Psycholinguistics; Recovery; Reporting; Research; Retrieval; Speech; Stimulus; Structure; System; Testing; Training; Treatment Protocols; Work; aphasia recovery; aphasia rehabilitation; base; design; efficacy study; efficacy testing; experience; experimental study; follow-up; improved; novel; sample fixation; syntax; theories; tool

Project Summary Implicit Structural Priming as a Treatment Component in Aphasia Impaired message-to-structure mapping is at the heart of communication deficits in persons with aphasia (PWA), resulting in impaired sentence production and comprehension. As of yet, the few treatment options available for the mapping deficits involve explicit metacognitive training of sentence production, yielding variable generalization and maintenance effects. Therefore, there remains a critical need to identify interventions that successfully improve mapping abilities in PWA. This project introduces implicit structural priming as a novel facilitator for language recovery in aphasia. Structural priming, a tendency to repeat or better process a current sentence because of its structural similarity to a previously experienced (“prime”) sentence, has been ubiquitously observed across decades of psycholinguistic research and viewed as a powerful tool to study the processes of implicit language learning. Preliminary studies reported in this application suggest that structural priming can be applied to PWA and might produce positive, enduring language recovery in PWA. The planned studies seek to test the hypothesis that implicit structural priming alters the central syntactic system in PWA, creating lasting and generalized improvements in both language production and comprehension. Aim 1 will determine the extent to which different manipulations of structural priming conditions modulate immediate and long-term improvement in sentence production. We integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced syntactic learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, we investigate whether the effects of structural priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross- modality generalization. In Aim 3, we develop and establish Phase I efficacy data of an implicit structural priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The outcomes of this work will lead to identification of a model of language (re-)learning in aphasia and the development of a novel treatment that capitalizes on the benefits of the implicit learning mechanisms underlying structural priming.

项目摘要 内隐结构启动作为失语症的治疗成分 信息到结构映射受损是慢性阻塞性肺疾病患者沟通障碍的核心 失语症(PWA)，导致句子发音和理解能力受损。到目前为止，为数不多的 针对映射缺陷的治疗方案包括对句子的显性元认知训练 生产，产出变量推广和维护效果。因此，仍然存在一个关键的 需要确定能够成功提高PWA地图绘制能力的干预措施。这个项目 介绍了内隐结构启动作为一种新的失语症语言恢复促进剂。结构性 启动，一种重复或更好地处理当前句子的倾向，因为它在结构上与 在过去的几十年里，人们普遍观察到了一个以前有过经验的(质数)句子 心理语言学研究，被视为研究内隐语言过程的有力工具 学习。在这项应用中报告的初步研究表明，可以应用结构性底漆 并可能在PWA中产生积极的、持久的语言恢复。计划中的研究试图 检验内隐结构启动改变PWA中枢句法系统的假设，创建 在语言产出和理解力方面的持久和普遍的进步。目标1将 确定结构启动条件的不同操作的调制程度 即刻和长期改善句子的制作。我们整合了多种理论 语言学习并应用它们来预测启动诱导的句法轨迹 在PWA学习。在目标2中，我们使用了一组眼动的句子理解任务，调查了 结构启动在生产中的作用是否概括为离线(精度)和在线(眼睛 注视)句子理解，并确定什么学习条件会导致更大的交叉- 情态泛化。在目标3中，我们开发和建立了隐含的一期疗效数据 结构性启动治疗，结合支持最大限度保持的关键学习条件 目标1和目标2。这项工作的结果将导致确定一种语言模式 (重新)失语症的学习和开发一种新的治疗方法，利用 结构启动背后的内隐学习机制。