Implicit Structural Priming as a Treatment Component in Aphasia

内隐结构启动作为失语症的治疗组成部分

• 批准号: 10623323
• 负责人: Jiyeon Lee
• 金额: $ 60.75万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623323
• 关键词: Affect; Aphasia; Assessment tool; Clinical; Communication; Comprehension; Data; Development; Eye; Goals; Heart; Impairment; Intervention; Language; Language Development; Learning; Linguistics; Maintenance; Maps; Measures; Modality; Modeling; Outcome; Outcome Measure; Participant; Persons; Phase; Process; Production; Psycholinguistics; Recovery; Reporting; Research; Retrieval; Speech; Stimulus; Structure; System; Testing; Training; Treatment Protocols; Work; aphasia recovery; aphasia rehabilitation; design; efficacy study; efficacy testing; experience; experimental study; follow-up; improved; novel; sample fixation; syntax; theories; tool; visual tracking

Project Summary Implicit Structural Priming as a Treatment Component in Aphasia Impaired message-to-structure mapping is at the heart of communication deficits in persons with aphasia (PWA), resulting in impaired sentence production and comprehension. As of yet, the few treatment options available for the mapping deficits involve explicit metacognitive training of sentence production, yielding variable generalization and maintenance effects. Therefore, there remains a critical need to identify interventions that successfully improve mapping abilities in PWA. This project introduces implicit structural priming as a novel facilitator for language recovery in aphasia. Structural priming, a tendency to repeat or better process a current sentence because of its structural similarity to a previously experienced (“prime”) sentence, has been ubiquitously observed across decades of psycholinguistic research and viewed as a powerful tool to study the processes of implicit language learning. Preliminary studies reported in this application suggest that structural priming can be applied to PWA and might produce positive, enduring language recovery in PWA. The planned studies seek to test the hypothesis that implicit structural priming alters the central syntactic system in PWA, creating lasting and generalized improvements in both language production and comprehension. Aim 1 will determine the extent to which different manipulations of structural priming conditions modulate immediate and long-term improvement in sentence production. We integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced syntactic learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, we investigate whether the effects of structural priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross- modality generalization. In Aim 3, we develop and establish Phase I efficacy data of an implicit structural priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The outcomes of this work will lead to identification of a model of language (re-)learning in aphasia and the development of a novel treatment that capitalizes on the benefits of the implicit learning mechanisms underlying structural priming.

项目摘要 内隐结构启动对失语症的治疗作用 受损的信息-结构映射是患有以下疾病的人的沟通缺陷的核心 失语症（PWA），导致句子产生和理解受损。到目前为止， 映射缺陷的治疗方案涉及句子的显式元认知训练 生产，产生变量泛化和维护效果。因此，仍然存在一个关键的 需要确定成功提高PWA绘图能力的干预措施。这个项目 介绍了内隐结构启动作为一种新的促进失语症的语言恢复。结构 启动，一种倾向，重复或更好地处理当前的句子，因为它的结构相似， 一个先前经历过的（“主要”）句子，在几十年的时间里被普遍观察到， 心理语言学研究被认为是研究隐性语言过程的有力工具 学习在本申请中报告的初步研究表明，结构启动可以应用于 可能会产生积极的，持久的语言恢复在PWA。计划中的研究旨在 检验隐性结构启动改变PWA中的中央句法系统的假设，创建 语言产生和理解方面的持久和普遍改善。目标1将 确定结构启动条件的不同操作调节的程度 立即和长期改进判决。我们整合了多种理论， 语言学习，并应用它们来预测启动诱导句法的轨迹 在PWA学习在目标2中，使用一组眼动句子理解任务，我们研究了 结构启动效应是否适用于离线（准确性）和在线（眼睛 固定）句子理解，并确定什么样的学习条件导致更大的交叉- 情态泛化在目标3中，我们开发并建立了一种隐式治疗的I期疗效数据， 结构启动处理，结合支持最大保留的关键学习条件 目标1和2。这项工作的结果将导致识别的语言模式 失语症的（重新）学习和开发一种新的治疗方法， 结构启动背后的内隐学习机制。