Neurocircuits that regulate circadian rhythms
调节昼夜节律的神经回路
基本信息
- 批准号:10445207
- 负责人:
- 金额:$ 48.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-04-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:ART proteinAreaBehaviorBehavioralCaloriesCircadian RhythmsConsumptionCoupledCuesDarknessDevelopmentDiseaseDorsalEatingElectrolytesExhibitsFeeding behaviorsFiberFoodGenesGlutamatesGoalsHomeostasisHumanHypothalamic structureIntakeKnowledgeLeptinLesionLightLinkLocomotionMapsMediatingMedical Care CostsMetabolicMetabolic DiseasesMetabolismModernizationMotor ActivityMusNeuronsNeurosciencesNutritionalObesityPathway interactionsPatternPeriodicityPhasePhotometryPhysiologicalPlayPredispositionPreventionPublishingReceptor SignalingRegulationReportingRodentRoleRunningSensorySignal TransductionSocietiesStructure of dorsomedial hypothalamic nucleusStructure of nucleus infundibularis hypothalamiSynapsesSystemTechniquesTestingViralVirusVisceralVisualWeightWorkcircadiancircadian regulationenergy balancefeedinggamma-Aminobutyric Acidgenetic approachin vivoleptin receptormetabolic phenotypemolecular clockneural circuitnovelobesity preventionobesity treatmentrelating to nervous systemresponsesensory inputsuprachiasmatic nucleustreatment strategy
项目摘要
Project Summary
While the systems that regulate circadian rhythms and energy homeostasis are tightly coupled together, the
pathways which connect them together are not well understood. Our recent findings have identified a novel,
physiological role for a subset of neurons in the dorsomedial hypothalamus (DMH) that express the leptin
receptor in the circadian control of feeding, locomotor activity and associated metabolic rhythms. The
overarching goal of this proposal is to identify the neurocircuitry linking circadian rhythms to control of DMH
leptin receptor (LepR) neurons and associated feeding and metabolic responses. Proposed aims seek to 1)
characterize the rhythmicity of DMH LepR neuronal activity; 2) identify the contribution made by specific
subsets of these neurons in the circadian control of feeding behavior, metabolism and locomotion, and 3) to
identify upstream regulators of DMH LepR neurons that regulate circadian control of feeding and metabolism.
To accomplish this, we will integrate advanced neuroscience techniques including in vivo fiber photometry,
viral track tracing and chemogenetic techniques, along with an intersectional genetics approach and
comprehensive rodent metabolic phenotyping. Together, this work will fundamentally advance our knowledge
of the neural circuits underlying endogenous rhythms of behavior, feeding, and metabolism and can be
expected to facilitate the development of new strategies for the treatment and prevention of obesity and related
disorders in humans.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GREGORY J MORTON其他文献
GREGORY J MORTON的其他文献
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{{ truncateString('GREGORY J MORTON', 18)}}的其他基金
CNS Mechanisms Governing Diabetic Hyperglycemia
中枢神经系统控制糖尿病高血糖的机制
- 批准号:
9221324 - 财政年份:2011
- 资助金额:
$ 48.96万 - 项目类别:
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