Thermoregulatory circuits that regulate feeding
调节喂养的温度调节电路
基本信息
- 批准号:10400898
- 负责人:
- 金额:$ 52.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-15 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteBiological ModelsBody TemperatureBody Weight decreasedBody fatBrainClosure by clampCoupledCuesCutaneousDataDoseEatingEnergy IntakeEnergy MetabolismEnsureEnvironmentExposure toFiberFutureGoalsHomeostasisHyperphagiaHypothalamic structureLeptinLinkMedial Dorsal NucleusMediatingMedical Care CostsMetabolicModelingModernizationMusNatureNeuronsNeurosciencesObesityPeptidesPerceptionPhotometryPhysiologic ThermoregulationPlasmaPlayPopulationPreoptic AreasRegulationReportingRoleSecondary toSkinSocietiesStressStructure of nucleus infundibularis hypothalamiSystemTechniquesTemperatureTemperature SenseThermogenesisTyrosine 3-MonooxygenaseWorkbasedesigner receptors exclusively activated by designer drugsenergy balanceexcessive weight gainfallsfeedingin vivometabolic phenotypeneural circuitnovelnovel strategiesobesity treatmentoptogeneticsparaventricular nucleuspituitary adenylate cyclase activating polypeptidepreventrecruitreduced food intakeresponsetemporal measurement
项目摘要
Project Summary
The thermoregulatory and energy homeostasis systems are tightly coupled to ensure the stability of both core
temperature and body fat stores across a wide range of environmental temperatures. This interaction is
highlighted by the adaptive metabolic response to cold exposure, as the increase of heat production needed to
maintain core temperature is accompanied by a proportionate increase in energy intake to maintain body fat
stress. These adaptive responses are rapid and robust and our recent findings implicate a role for agouti-
related peptide (Agrp) neurons in the adaptive feeding response since Agrp neurons are activated during cold-
exposure, and this activation is required for cold-induced hyperphagia, but not cold-induced thermogenic
responses. The overarching goal of the proposal is to identify the neurocircuitry linking thermoregulation to
control of Agrp neuronal activity and associated feeding responses. Proposed studies seek 1) to examine the
temporal relationship between changes in ambient temperature, Agrp neuron activity and associated feeding
responses and 2) to identify and characterize neurocircuits that link thermoregulation to cold-induced
hyperphagia. To accomplish this, state-of-the-art neuroscience techniques including chemogenetics,
optogenetics and fiber photometry systems approaches are utilized, in combination with immunohistochemical
and advanced metabolic phenotyping. Together, this work will advance the understanding of the neurocircuitry
linking thermoregulation to Agrp neurons and feeding and may identify novel strategies for the treatment of
obesity by blunting the associated hyperphagic response.
项目摘要
体温调节和能量稳态系统紧密耦合,以确保两个核心的稳定性。
温度和身体脂肪储存在广泛的环境温度范围内。这种相互作用
强调了适应性代谢反应冷暴露,因为需要增加热量生产,
维持核心温度伴随着能量摄入的成比例增加,以维持身体脂肪
应力这些适应性反应是快速和强大的,我们最近的发现暗示了agglutinin的作用,
相关肽(Agrp)神经元在适应性摄食反应中的作用,因为Agrp神经元在冷-
暴露,这种激活是冷诱导的摄食过多所必需的,但不是冷诱导的产热
应答该提案的首要目标是确定神经回路连接温度调节,
控制Agrp神经元活性和相关的进食反应。拟议的研究寻求1)审查
环境温度变化、Agrp神经元活动和相关摄食之间的时间关系
反应和2)识别和表征将体温调节与冷诱导联系起来的神经回路
食欲过盛为了实现这一点,最先进的神经科学技术,包括化学遗传学,
光遗传学和纤维光度测定系统方法与免疫组织化学结合使用。
和高级代谢表型。总之,这项工作将促进对神经回路的理解,
将体温调节与Agrp神经元和进食联系起来,并可能确定治疗
通过减弱相关的摄食过多反应来治疗肥胖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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- 资助金额:
$ 52.56万 - 项目类别:
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