Energy Balance Core
能量平衡核心
基本信息
- 批准号:10426297
- 负责人:
- 金额:$ 21.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-12-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAnalysis of CovarianceAnimal ModelAnimalsAreaBehavioralBiological AssayBiological ProcessBiopsy SpecimenBody TemperatureBrown FatCardiovascular DiseasesCommunitiesComputer softwareConsultDataData AnalysesDevelopmentDiabetes MellitusEducational process of instructingEducational workshopEnergy IntakeEnergy MetabolismEnsureEquipmentFundingGoldHigh PrevalenceHomeostasisHuman ResourcesHumidityHypertensionIndirect CalorimetryInterventionKnowledgeLeadershipLinear RegressionsMeasurementMeasuresMetabolicMethodsModelingMonitorMusNational Institute of Diabetes and Digestive and Kidney DiseasesNutritional ScienceObesityPathogenesisPatternPerformancePharmacologyPhenotypePhysiologic ThermoregulationPhysiologicalPhysiologyPlayProceduresProcessProductivityProviderPublic HealthQuality ControlRegulationResearchResearch DesignResearch PersonnelResourcesRodentRodent ModelRoleRunningScientific Advances and AccomplishmentsServicesTailTechniquesTemperatureTestingThermogenesisTimeTissuesTrainingTraining ActivityUniversitiesWashingtonbasecomorbiditycost effectivedesignenergy balanceevidence based guidelinesexperiencegenetic manipulationimprovedinnovationinstrumentationinterestmetabolic abnormality assessmentmetabolic phenotypenext generationnovel therapeutic interventionnutritionorganizational structureprogramsrespiratoryservice providerstherapeutically effectivetooltraining opportunity
项目摘要
The Energy Balance Core is directed by Greg Morton, with Joshua Thaler serving as Associate Core Director.
The primary function of this Core is to provide Affiliate Investigators (AIs) with state-of-the-art resources for
comprehensive metabolic phenotyping of rodents. The Specific Aims for the Energy Balance Core are:
Specific Aim 1: To provide AIs with a state-of-the-art resource for comprehensive energy balance
and metabolic phenotyping of rodent models relevant to nutrition and obesity.
The EB Core provides comprehensive quantitative assessment of energy balance parameters including indirect
calorimetry with energy expenditure normalization by multiple linear regression, body and tissue composition on
living and biopsied specimens, ambulatory activity, wheel running activity and energy intake with meal pattern
analysis. We also offer video monitoring services and extensive thermoregulatory services including continuous
core body temperature monitoring, calculation of thermal conductance, thermal gradient tests, and measures of
brown adipose tissue and tail-temperature that can be performed at any ambient temperature using temperature-
controlled chambers. As the EB Core is the sole provider of these services in the Seattle area, the UW NORC
plays a critical role in the productivity and scientific advances of the nutrition and obesity research community.
Specific Aim 2: To create an organizational structure that ensures that services are provided to AIs
in a timely, efficient and cost-effective manner and that quality control for all services is routinely
assessed.
We optimize the scope of services offered and ensure that they fit seamlessly and without overlap with services
offered via other UW programs and centers. To ensure services are provided to AIs in a timely and efficiency
manner, the EB Core has implemented a streamlined process for animal transfers and handling; have highly
skilled and trained personnel with extensive experience managing technically demanding equipment to ensure
consistency and quality control; and strong leadership with expertise in the design, performance, analysis and
interpretation of rodent metabolic phenotypes related to nutrition and obesity.
Specific Aim 3: To develop new services that keep pace with relevant technological advances and
address the evolving needs of our user base.
Over the past 5 years, we have incorporated a number of innovative techniques into our expanded menu of
offered services. We obtained a thermocline and temperature-controlled metabolic chambers for adaptive
thermogenesis studies and introduced quantitative approaches to measure thermal conductance. In addition,
we devote time and resources to teaching and training activities both to our NORC AIs and the broader scientific
community, including normalization of energy expenditure data and the development of a seminar and workshop
related to the regulation of energy homeostasis and use of indirect calorimetry equipment.
能量平衡核心由格雷格·莫顿(Greg Morton)执导,约书亚·塞勒(Joshua Thaler)担任副核心主任。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GREGORY J MORTON其他文献
GREGORY J MORTON的其他文献
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{{ truncateString('GREGORY J MORTON', 18)}}的其他基金
CNS Mechanisms Governing Diabetic Hyperglycemia
中枢神经系统控制糖尿病高血糖的机制
- 批准号:
9221324 - 财政年份:2011
- 资助金额:
$ 21.37万 - 项目类别:
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