Energy Balance Core

能量平衡核心

• 批准号: 10426297
• 负责人: GREGORY J MORTON
• 金额: $ 21.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426297
• 关键词: Address; Analysis of Covariance; Animal Model; Animals; Area; Behavioral; Biological Assay; Biological Process; Biopsy Specimen; Body Temperature; Brown Fat; Cardiovascular Diseases; Communities; Computer software; Consult; Data; Data Analyses; Development; Diabetes Mellitus; Educational process of instructing; Educational workshop; Energy Intake; Energy Metabolism; Ensure; Equipment; Funding; Gold; High Prevalence; Homeostasis; Human Resources; Humidity; Hypertension; Indirect Calorimetry; Intervention; Knowledge; Leadership; Linear Regressions; Measurement; Measures; Metabolic; Methods; Modeling; Monitor; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Nutritional Science; Obesity; Pathogenesis; Pattern; Performance; Pharmacology; Phenotype; Physiologic Thermoregulation; Physiological; Physiology; Play; Procedures; Process; Productivity; Provider; Public Health; Quality Control; Regulation; Research; Research Design; Research Personnel; Resources; Rodent; Rodent Model; Role; Running; Scientific Advances and Accomplishments; Services; Tail; Techniques; Temperature; Testing; Thermogenesis; Time; Tissues; Training; Training Activity; Universities; Washington; base; comorbidity; cost effective; design; energy balance; evidence based guidelines; experience; genetic manipulation; improved; innovation; instrumentation; interest; metabolic abnormality assessment; metabolic phenotype; next generation; novel therapeutic intervention; nutrition; organizational structure; programs; respiratory; service providers; therapeutically effective; tool; training opportunity

The Energy Balance Core is directed by Greg Morton, with Joshua Thaler serving as Associate Core Director. The primary function of this Core is to provide Affiliate Investigators (AIs) with state-of-the-art resources for comprehensive metabolic phenotyping of rodents. The Specific Aims for the Energy Balance Core are: Specific Aim 1: To provide AIs with a state-of-the-art resource for comprehensive energy balance and metabolic phenotyping of rodent models relevant to nutrition and obesity. The EB Core provides comprehensive quantitative assessment of energy balance parameters including indirect calorimetry with energy expenditure normalization by multiple linear regression, body and tissue composition on living and biopsied specimens, ambulatory activity, wheel running activity and energy intake with meal pattern analysis. We also offer video monitoring services and extensive thermoregulatory services including continuous core body temperature monitoring, calculation of thermal conductance, thermal gradient tests, and measures of brown adipose tissue and tail-temperature that can be performed at any ambient temperature using temperature- controlled chambers. As the EB Core is the sole provider of these services in the Seattle area, the UW NORC plays a critical role in the productivity and scientific advances of the nutrition and obesity research community. Specific Aim 2: To create an organizational structure that ensures that services are provided to AIs in a timely, efficient and cost-effective manner and that quality control for all services is routinely assessed. We optimize the scope of services offered and ensure that they fit seamlessly and without overlap with services offered via other UW programs and centers. To ensure services are provided to AIs in a timely and efficiency manner, the EB Core has implemented a streamlined process for animal transfers and handling; have highly skilled and trained personnel with extensive experience managing technically demanding equipment to ensure consistency and quality control; and strong leadership with expertise in the design, performance, analysis and interpretation of rodent metabolic phenotypes related to nutrition and obesity. Specific Aim 3: To develop new services that keep pace with relevant technological advances and address the evolving needs of our user base. Over the past 5 years, we have incorporated a number of innovative techniques into our expanded menu of offered services. We obtained a thermocline and temperature-controlled metabolic chambers for adaptive thermogenesis studies and introduced quantitative approaches to measure thermal conductance. In addition, we devote time and resources to teaching and training activities both to our NORC AIs and the broader scientific community, including normalization of energy expenditure data and the development of a seminar and workshop related to the regulation of energy homeostasis and use of indirect calorimetry equipment.

能量平衡核心是由格雷格莫顿，与约书亚泰勒担任副核心主任。 本核心的主要功能是为关联研究者（AI）提供最先进的资源， 啮齿类动物的综合代谢表型。能量平衡核心的具体目标是： 具体目标1：为认可机构提供先进的资源，以实现全面的能源平衡 以及与营养和肥胖相关的啮齿动物模型的代谢表型。 EB Core提供了能量平衡参数的全面定量评估，包括间接 通过多元线性回归进行能量消耗标准化的量热法， 活体和活检标本、步行活动、轮跑活动和膳食模式下的能量摄入 分析.我们还提供视频监控服务和广泛的体温调节服务， 核心体温监测、热导率计算、热梯度测试和 棕色脂肪组织和尾部温度，可以在任何环境温度下使用温度- 控制室。由于EB Core是西雅图地区这些服务的唯一提供商，UW NORC 在营养和肥胖研究界的生产力和科学进步中起着关键作用。 具体目标2：建立一个确保向认可机构提供服务的组织架构 确保以及时、有效和具有成本效益的方式提供服务，并定期对所有服务进行质量控制， 评估。 我们优化所提供的服务范围，并确保它们无缝匹配，不会与服务重叠 通过其他UW计划和中心提供。确保向认可机构提供的服务能及时及有效率地提供 以这种方式，EB核心实施了简化的动物转移和处理流程;具有高度的 技术熟练、训练有素的人员，拥有管理技术要求高的设备的丰富经验， 一致性和质量控制;以及在设计，性能，分析和 啮齿动物代谢表型与营养和肥胖相关的解释。 具体目标3：开发新的服务，跟上相关技术进步的步伐， 满足我们用户群不断变化的需求。 在过去的5年里，我们已经将一些创新技术纳入我们的扩展菜单， 提供的服务。我们获得了一个温跃层和温度控制的代谢室， 研究生热，并介绍了定量方法来测量热导率。此外，本发明还提供了一种方法， 我们将时间和资源投入到我们的NORC AI和更广泛的科学教学和培训活动中， 包括能源支出数据的正常化和举办研讨会和讲习班 与调节能量稳态和使用间接量热设备有关。