Function Core - Core C

功能核心-核心C

• 批准号: 10459376
• 负责人: Daniel E Michele
• 金额: $ 14.57万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459376
• 关键词: Address; Affect; Age; Animal Disease Models; Animal Model; Animal Organ; Animals; Attention; Basic Science; Biology; Biomechanics; Biophysics; Cartilage; Collaborations; Communities; Complement; Data Analyses; Data Analytics; Disease; Disease Outcome; Engineering; Environment; Equipment; Experimental Designs; Financial Support; Fostering; Funding; Genetic; Genomics; Goals; Growth; Health; Histology; Human; Human Development; Inbred Strain; Individual; Injury; Knowledge; Laboratories; Lead; Leadership; Ligaments; Measurement; Measures; Mechanics; Methodology; Michigan; Molecular; Muscle; Muscle function; Musculoskeletal; Musculoskeletal Development; Musculoskeletal Diseases; Musculoskeletal System; Organ; Organism; Pathogenesis; Pathology; Pathway interactions; Phenotype; Physiology; Proteomics; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resolution; Resources; Rodent; Scientist; Services; Specificity; Standardization; Structure; Surgical Models; Techniques; Technology; Tendon structure; Testing; Time; Tissue Banks; Tissue imaging; Training; Universities; animal tissue; base; bone; cost; experience; experimental study; improved; in vivo; innovation; multimodal data; multimodality; neuromuscular function; new technology; novel; pre-clinical assessment; pre-clinical research; preclinical study; response to injury; sex; soft tissue; targeted treatment; therapeutic evaluation; therapy outcome; tissue regeneration; tool

Michigan Integrative Musculoskeletal Health Core Center – Core C Project Summary Discovery of new targets and treatments for musculoskeletal diseases requires a deep understanding of the basic biology of musculoskeletal development and function, rigorous research into the fundamental mechanisms of disease pathogenesis, and robust testing of therapeutic targets and therapies aimed at improving disease outcome. Research using animal models is a cornerstone of these efforts enabling the study of organ and integrative organism function, the impact of environment, age, sex, and genetics on disease, and testing therapies and outcomes with disease-relevant measures. The ability to study musculoskeletal phenotypes across a wide-ranging scale of animal models requires considerable expertise and highly specialized training in physiology, biophysics, and engineering, as well as access to costly, high-resolution, state-of-the-art equipment. While occasionally the expertise and equipment for single approaches can be developed in a single laboratory, developing these approaches can be cost prohibitive, redundant, and can lead to proliferation of non-uniform techniques across the field. Rigorous and reproducible basic and preclinical research also requires robust experimental planning that can span multi-modal testing platforms from cellular and organ level function to in vivo physiology testing, in order to provide a fully comprehensive measure of phenotype or disease pathology. In cross-disciplinary research, innovation often arises from collaborations that extend beyond the limits of expertise in individual investigator laboratories alone. The overall long-term goal of the Function Core (Core C) of the Michigan Integrative Musculoskeletal Health Center (MiMHC) is to provide state-of-the-art animal and organ level phenotyping resources at the University of Michigan that can be used by the entire musculoskeletal research community, regardless of individual expertise. The Core brings together the leadership and technical experts in the physiology and biomechanics of the musculoskeletal system to provide fully staffed, specialized laboratory approaches to musculoskeletal biology including whole animal in vivo phenotyping and surgical models of musculoskeletal disease, and state-of-the-art measurements in bone mechanics, muscle function and mechanics, tendon mechanics, and neuromuscular function. Further emphasis on training and sharing of new technologies, standardization, and collaboration will expand the impact of Core C for our users and the broader musculoskeletal research community.

密歇根综合肌肉骨骼健康核心中心-核心C 项目摘要 发现肌肉骨骼疾病的新靶点和治疗方法需要深入了解 肌肉骨骼发育和功能的基础生物学，对基本机制的严格研究 疾病发病机制，以及旨在改善疾病的治疗靶点和疗法的稳健测试 结果。使用动物模型的研究是这些努力的基石，使器官和组织的研究成为可能。 综合有机体功能，环境，年龄，性别和遗传对疾病的影响，以及测试 治疗和结果与疾病相关的措施。研究肌肉骨骼表型的能力 在动物模型的广泛规模需要相当多的专业知识和高度专业化的培训， 生理学，生物物理学和工程学，以及获得昂贵的，高分辨率的，最先进的设备。 虽然偶尔可以在一个实验室中开发出用于单一方法的专门知识和设备， 开发这些方法可能是成本高昂的，多余的，并可能导致不均匀的扩散。 技术跨越领域。严格和可重复的基础和临床前研究还需要强大的 实验规划，可以跨越多模态测试平台，从细胞和器官水平的功能，以 体内生理学测试，以便提供表型或疾病病理学的完全全面的测量。 在跨学科研究中，创新往往源于超越学科界限的合作。 仅在个别研究者实验室的专业知识。功能核心（Core C）的总体长期目标 密歇根州综合肌肉骨骼健康中心（MiMHC）将提供最先进的动物和 密歇根大学的器官水平表型资源，可用于整个肌肉骨骼 研究社区，无论个人的专业知识。核心将领导力和技术 在肌肉骨骼系统的生理学和生物力学的专家，提供充分的人员配备，专业 肌肉骨骼生物学的实验室方法，包括整个动物体内表型分析和外科手术 肌肉骨骼疾病模型以及骨力学、肌肉功能和 力学、肌腱力学和神经肌肉功能。进一步强调培训和分享新的 技术、标准化和协作将扩大Core C对我们用户的影响， 肌肉骨骼研究社区。