权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Function Core - Core C

功能核心-核心C

基本信息

批准号：
10676787
负责人：
Daniel E Michele
金额：
$ 14.57万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676787
关键词：
Address Affect Age Animal Model Animals Attention Basic Science Biology Biomechanics Biophysics Cartilage Collaborations Communities Complement Data Analyses Data Analytics Disease Disease Outcome Disease model Engineering Environment Equipment Experimental Designs Financial Support Fostering Funding Genetic Genomics Goals Growth Health Histology Human Human Development Inbred Strain Individual Injury Knowledge Laboratories Leadership Ligaments Measurement Measures Mechanics Methodology Michigan Molecular Muscle Muscle function Musculoskeletal Musculoskeletal Development Musculoskeletal Diseases Musculoskeletal System Organ Organism Outcome Pathogenesis Pathology Pathway interactions Phenotype Physiology Proliferating Proteomics Reproducibility Research Research Design Research Personnel Research Project Grants Resolution Resources Rodent Scientist Services Specificity Standardization Structure Surgical Models Techniques Technology Tendon structure Testing Tissue Banks Tissue imaging Tissues Training Universities base bone community engagement cost experience experimental study improved in vivo innovation multimodal data multimodality neuromuscular function new technology novel pre-clinical assessment pre-clinical research preclinical study response to injury sex soft tissue targeted treatment therapeutic evaluation therapeutic target tissue regeneration tool

项目摘要

Michigan Integrative Musculoskeletal Health Core Center – Core C Project Summary Discovery of new targets and treatments for musculoskeletal diseases requires a deep understanding of the basic biology of musculoskeletal development and function, rigorous research into the fundamental mechanisms of disease pathogenesis, and robust testing of therapeutic targets and therapies aimed at improving disease outcome. Research using animal models is a cornerstone of these efforts enabling the study of organ and integrative organism function, the impact of environment, age, sex, and genetics on disease, and testing therapies and outcomes with disease-relevant measures. The ability to study musculoskeletal phenotypes across a wide-ranging scale of animal models requires considerable expertise and highly specialized training in physiology, biophysics, and engineering, as well as access to costly, high-resolution, state-of-the-art equipment. While occasionally the expertise and equipment for single approaches can be developed in a single laboratory, developing these approaches can be cost prohibitive, redundant, and can lead to proliferation of non-uniform techniques across the field. Rigorous and reproducible basic and preclinical research also requires robust experimental planning that can span multi-modal testing platforms from cellular and organ level function to in vivo physiology testing, in order to provide a fully comprehensive measure of phenotype or disease pathology. In cross-disciplinary research, innovation often arises from collaborations that extend beyond the limits of expertise in individual investigator laboratories alone. The overall long-term goal of the Function Core (Core C) of the Michigan Integrative Musculoskeletal Health Center (MiMHC) is to provide state-of-the-art animal and organ level phenotyping resources at the University of Michigan that can be used by the entire musculoskeletal research community, regardless of individual expertise. The Core brings together the leadership and technical experts in the physiology and biomechanics of the musculoskeletal system to provide fully staffed, specialized laboratory approaches to musculoskeletal biology including whole animal in vivo phenotyping and surgical models of musculoskeletal disease, and state-of-the-art measurements in bone mechanics, muscle function and mechanics, tendon mechanics, and neuromuscular function. Further emphasis on training and sharing of new technologies, standardization, and collaboration will expand the impact of Core C for our users and the broader musculoskeletal research community.

密歇根综合肌肉骨骼健康核心中心-核心C