Training Program in Translational Cardiovascular Research and Entrepreneurship

摘要 这项更新提案寻求继续为转化性心血管培训计划提供资金 密歇根大学研究与创业(CVRE)。心血管疾病是最主要的 全球范围内的死因。该项目的使命是培养下一代寻求 心血管研究的伦理发展和研究成果的应用 从实验室到床边，最终目标是改善患者的治疗。拟议中的培训 该计划旨在解决年轻基础科学家和博士前培训方面的差距 转化型心血管研究关键领域的学生，如临床前研究设计、药物 发现、设备/治疗开发、优化和测试、研究创业和监管 合规性。该项目的跨学科和国际公认的教师提供了 卓越的培训环境，包括最先进的设施和技术，跨越遗传， 心血管疾病的分子、细胞、系统、工程和临床研究。通过 充分利用我们在基础、临床前和转化性心血管方面的现有教员优势 研究，和密歇根大学独特的学术资源，我们将培养学生不仅在州 最先进的生物医学研究，也在应用系统生物学进行临床前测试，导航监管 合规，以及研究创业的过程和挑战。因此，该计划提供 学生在翻译研究培训中获得独特的全面和身临其境的教育体验。 额外的好处是，该计划还将使学生为多样化的科学职业做好准备 青年科学家，包括学术研究、初创公司、生物技术和 大型制药和设备公司。翻译CVRE计划将吸引博士生 来自弗兰克尔心血管中心教职员工成员的实验室候选人级别，来自 在医学院范围内的生物医学科学项目中非常强大的研究生课程，以及 工程学院和药学院。为每年5个实习生职位申请资金，以及 学生可以通过竞争续签获得第二年的连任。计划的主要功能如下1) 关于翻译相关研究课题的强有力的基础研究培训 NHLBI任务2)临床前研究设计和表型测试方面的培训3)授课和 研究型创业的体验式学习与职业道路相关技能 发展。通过让学生接触基础心血管研究、生物医学 工程学和心血管医学，我们希望更好地为下一代博士科学家做好准备 成为基础研究发现的领导者，并有能力为他们的临床指明方向。

Abstract This renewal proposal seeks continued funding for the Training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. The mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the laboratory to the bedside, with the ultimate goal of improving therapy for patients. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, research entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic, preclinical, and translational cardiovascular research, and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and the process and challenges of research entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive educational experience in translational research training. The added benefit is that the program will also prepare students for the diversity of scientific careers available to and often pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The Translational CVRE program will attract trainees at the PhD Candidate level from laboratories across the Frankel Cardiovascular Center faculty membership, from exceptionally strong graduate programs in the medical school wide Program in Biomedical Sciences, and the College of Engineering and School of Pharmacy. Funds are requested for 5 trainee slots per year, and students may be reappointed for a second year by competitive renewal. The key program features are 1) strong, fundamental basic research training on translationally relevant research topics under the NHLBI mission 2) training in preclinical research design and phenotypic testing 3) didactic and experiential learning on research entrepreneurship along with career path relevant skills development. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be leaders at taking basic research discoveries and being capable of directing their path to the clinic.