Training Program in Translational Cardiovascular Research and Entrepreneurship

转化心血管研究和创业培训计划

• 批准号: 10642864
• 负责人: Daniel E Michele
• 金额: $ 23.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642864
• 关键词: Cardiovascular system; Entrepreneurship; Research; Training Programs

Abstract This renewal proposal seeks continued funding for the Training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. The mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the laboratory to the bedside, with the ultimate goal of improving therapy for patients. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, research entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic, preclinical, and translational cardiovascular research, and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and the process and challenges of research entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive educational experience in translational research training. The added benefit is that the program will also prepare students for the diversity of scientific careers available to and often pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The Translational CVRE program will attract trainees at the PhD Candidate level from laboratories across the Frankel Cardiovascular Center faculty membership, from exceptionally strong graduate programs in the medical school wide Program in Biomedical Sciences, and the College of Engineering and School of Pharmacy. Funds are requested for 5 trainee slots per year, and students may be reappointed for a second year by competitive renewal. The key program features are 1) strong, fundamental basic research training on translationally relevant research topics under the NHLBI mission 2) training in preclinical research design and phenotypic testing 3) didactic and experiential learning on research entrepreneurship along with career path relevant skills development. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be leaders at taking basic research discoveries and being capable of directing their path to the clinic.

抽象的 该更新提案寻求继续为转化心血管培训计划提供资金 密歇根大学的研究与企业家精神（CVRE）。心血管疾病是领先的 全球死亡原因。该计划的任务是培训下一代的博士学位科学家寻求 心血管研究的职业在道德发展和研究中的职业。 床边的实验室，其最终目的是改善患者的治疗。拟议的培训 计划的旨在解决培训年轻基础科学家和博士前的培训的差距 转化心血管研究的关键领域的学生，例如临床前研究设计，药物 发现，设备/治疗开发，优化和测试，研究企业家精神和监管 遵守。该计划的跨学科和国际认可的学院提供了 出色的培训环境，包括跨越遗传的最先进的设施和技术， 分子，细胞，系统，工程和血管疾病的临床研究。经过 利用基本，临床前和转化心血管的现有优势 在密歇根大学的研究和独特的学术资源，我们不仅将在州培训学生 艺术生物医学研究，但也将系统生物学应用于临床前测试 合规性以及研究企业家精神的过程和挑战。因此，该程序提供 学生在翻译研究培训中具有独特的全面和身临其境的教育经验。 额外的好处是该计划还将为学生做好科学职业多样性的准备 年轻科学家，包括学术研究，初创公司，生物技术和 大型制药公司和设备公司。翻译CVRE计划将吸引博士学位的受训者 来自弗兰克尔心血管中心教职员工的实验室的候选级别，来自 在医学院广泛的生物医学科学课程中，非常强大的研究生课程， 工程学院和药学院。每年要求提供5个学员的资金，并且 竞争性更新可能会重新任命学生第二年。关键程序功能是1） 关于翻译相关研究主题的强大，基本的基础研究培训 NHLBI任务2）临床前研究设计和表型测试的培训3）教学和 研究企业家精神的体验式学习以及职业道路相关技能 发展。通过将学生置于基本心血管研究之间的界面，生物医学 工程和心血管医学，我们希望更好地准备下一代博士学位科学家 成为研究基础研究发现并能够将其通往诊所的道路的领导者。

项目成果

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues.

基质结构和力学调节肌原纤维组织、肋骨组装和工程心肌微组织的收缩性。

• DOI: 10.1101/2023.10.20.563346
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: DePalma,SamuelJ;Jillberto,Javiera;Stis,AustinE;Huang,DarcyD;Lo,Jason;Davidson,ChristopherD;Chowdhury,Aamilah;Jewett,MaggieE;Kobeissi,Hiba;Chen,ChristopherS;Lejeune,Emma;Helms,AdamS;Nordsletten,DavidA;Baker,BrendonM
• 通讯作者: Baker,BrendonM

A systems mechanobiology model to predict cardiac reprogramming outcomes on different biomaterials.

• DOI: 10.1016/j.biomaterials.2018.07.036
• 发表时间: 2018-10
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Kong YP;Rioja AY;Xue X;Sun Y;Fu J;Putnam AJ
• 通讯作者: Putnam AJ

Distributed vasculogenesis from modular agarose-hydroxyapatite-fibrinogen microbeads.

• DOI: 10.1016/j.actbio.2017.03.050
• 发表时间: 2017-06
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Rioja AY;Daley ELH;Habif JC;Putnam AJ;Stegemann JP
• 通讯作者: Stegemann JP

Apolipoprotein-mimetic nanodiscs reduce lipid accumulation and improve liver function in acid sphingomyelinase deficiency.

• DOI: 10.1016/j.nano.2023.102705
• 发表时间: 2023-09
• 期刊: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
• 影响因子: 5.4
• 作者: Halseth, Troy A.;Correia, Adele B.;Schultz, Mark L.;V. Fawaz, Maria;Kuiper, Esmee Q.;Kumaran, Preethi;Dorsey, Kristen Hong;Schuchman, Edward H.;Lieberman, Andrew P.;Schwendeman, Anna
• 通讯作者: Schwendeman, Anna

Dendrimer-doxorubicin conjugates exhibit improved anticancer activity and reduce doxorubicin-induced cardiotoxicity in a murine hepatocellular carcinoma model.

• DOI: 10.1371/journal.pone.0181944
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kuruvilla SP;Tiruchinapally G;Crouch AC;ElSayed MEH;Greve JM
• 通讯作者: Greve JM