Visualsonics Vevo 3100 Ultrasound Imaging

Visualsonics Vevo 3100 超声成像

• 批准号: 10417498
• 负责人: Daniel E Michele
• 金额: $ 32.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10417498
• 关键词: 3-Dimensional; 4D Imaging; Aging; Anatomy; Aneurysm; Animal Model; Animals; Atherosclerosis; Blood Pressure; Blood Vessels; Cardiac; Cardiovascular Diseases; Color; Computer software; Disease; Disease model; Drug Delivery Systems; Electrocardiogram; Embryo; Equipment; Frequencies; Functional Imaging; Funding; Genetic Engineering; Heart; Image; Laboratory Animals; Longevity; Magnetic Resonance Imaging; Mechanics; Michigan; Modality; Mus; Neoplasms in Vascular Tissue; Oryctolagus cuniculus; Outcome; Pathogenesis; Phenotype; Physiological; Physiology; Preclinical Testing; Protocols documentation; Rattus; Request for Applications; Research Personnel; Resolution; Respiration; Rodent; Series; Services; Structure; Surgical Models; Telemetry; Three-Dimensional Imaging; Thrombosis; Time; Transducers; Tumor Volume; Ultrasonography; United States National Institutes of Health; Universities; Vascular Diseases; cost; end of life; experience; heart imaging; human disease; image reconstruction; imaging system; novel; novel therapeutics; operation; pre-clinical research; preclinical study; repaired; tool; ultrasound

Abstract Rodent animal models, including genetically engineered animals, surgical models, and naturally occurring disease models, remain the cornerstone of preclinical research, and are routinely used to study the mechanisms and pathogenesis of human disease and develop new therapies. High resolution ultrasound imaging is an essential phenotyping tool to be able to study internal animal anatomy and physiology non- invasively across the animal’s lifespan, during disease pathogenesis, and before or after preclinical testing of treatments. This SIG application requests funds to purchase a Visualsonics Vevo3100 Ultrasound Imaging System. This new imaging system will be essential to the operations of the Physiology Phenotyping Core, which has almost two decades of experience in providing ultrasound imaging to NIH funded investigators across the University of Michigan Campus. The new Vevo3100 will replace an aging Vevo 2100 that has reached its end of supported lifespan and routinely requires costly repairs. The Vevo3100 utilizes very high frequency linear array MX-series transducers that provide the highest resolution 2D and 3D imaging of small animal heart structure and function available, and also allow for quantitative, functional imaging of blood vessels and tumor volumes in animals as small as mouse embryos and up to large rats and rabbits. EKG and respiration gating and EKV Software provide unparalleled cine loop image reconstruction during the cardiac cycle at up to 10,000 frames per second, and enables a novel 4D Imaging Mode (3D + time) to capture 3D imaging of the heart during the cardiac cycle at near MRI levels of resolution but at a fraction of the time and cost. In addition, the VevoVasc imaging analysis and high-resolution color Doppler imaging provides a capability of analyzing consequences of vascular disease including aneurysms, atherosclerosis and the physiological effects of thrombosis. Importantly, the Vevo3100 will be incorporated into a robust, fully functional animal phenotyping core with expert ultrasound technical staff, an efficient recharge mechanism, standing animal protocols, procedural space, and laboratory animal support to ease access to novice or expert users across the university. The core also provides users access to surgical models of cardiovascular disease, telemetry recording, blood pressure, drug delivery and other phenotyping modalities which provide a pipeline for preclinical studies from disease models to experimental outcomes. For example, when combined with the blood pressure telemetry services available in the Physiology Phenotyping Core, VevoVasc allows for real-time non-invasive analysis of vascular wall mechanics. Overall, the Vevo3100 will allow the Physiology Phenotyping Core to provide new state of the art modes of functional ultrasound imaging to NIH funded users, and by replacing aging end-of-life equipment will allow the core to continue to provide ultrasound services to users into the next decade.

摘要 啮齿类动物模型，包括基因工程动物、手术模型和自然发生的 疾病模型，仍然是临床前研究的基石，并经常用于研究 研究人类疾病的机制和发病机理，并开发新的治疗方法。高分辨率超声 成像是能够研究内部动物解剖学和生理学的基本表型分析工具， 在动物的整个生命周期中，在疾病发病过程中，以及在临床前试验之前或之后， 治疗。此SIG申请要求资金购买Visualsonics Vevo3100超声成像 系统这种新的成像系统将是必不可少的生理表型核心的运作， 该公司在为NIH资助的研究人员提供超声成像方面拥有近20年的经验 在密歇根大学的校园里。新的Vevo3100将取代老化的Vevo 2100， 已达到其支持寿命的终点，并且经常需要昂贵的维修。Vevo3100利用非常高的 频率线性阵列MX系列探头，提供最高分辨率的2D和3D成像， 动物心脏结构和功能，并且还允许血液的定量功能成像 小至小鼠胚胎，大至大鼠和兔子的动物中的血管和肿瘤体积。心电图和 呼吸门控和EKV软件提供了无与伦比的电影回放图像重建， 循环速度高达每秒10，000帧，并支持新颖的4D成像模式（3D +时间）， 在心动周期期间以接近MRI分辨率水平但在一小部分时间内对心脏进行成像， 成本此外，VevoVasc成像分析和高分辨率彩色多普勒成像提供了 分析血管疾病后果的能力，包括动脉瘤、动脉粥样硬化和 血栓形成的生理效应。重要的是，Vevo3100将被纳入一个强大的，完全 功能性动物表型鉴定核心，配备专业的超声技术人员，高效的充电机制， 常设动物协议，程序空间和实验室动物支持，以方便新手或专家 整个大学的用户。该核心还为用户提供了心血管疾病的手术模型， 遥测记录、血压、药物输送和其他表型模式， 用于从疾病模型到实验结果的临床前研究。例如，当与 VevoVasc生理表型核心中提供的血压遥测服务允许实时 血管壁力学的非侵入性分析。总的来说，Vevo3100将允许生理学 表型核心为NIH资助的用户提供最先进的功能性超声成像新模式， 通过更换老化的报废设备，将使核心继续提供超声服务， 用户进入下一个十年。