Core-003: Functional Assessment Core

Core-003：功能评估核心

• 批准号: 9087507
• 负责人: Daniel E Michele
• 金额: $ 26.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9087507
• 关键词: Adopted; Affect; Animal Model; Animal Organ; Animals; Area; Biology; Biophysics; Collaborations; Communities; Data; Development; Disease; Disease Pathway; Education; Engineering; Equipment; Experimental Designs; Financial Support; Future; Goals; Health; Hereditary Disease; Human; Inbred Strain; Individual; Institution; Integrative Medicine; Knowledge; Laboratories; Lead; Ligaments; Measurement; Measures; Mechanics; Methodology; Michigan; Mission; Modeling; Molecular; Mus; Muscle function; Musculoskeletal; Musculoskeletal Diseases; Organ; Organism; Outcome; Output; Patients; Phenotype; Physiological; Physiology; Procedures; Rattus; Recommendation; Research; Research Personnel; Resolution; Resource Sharing; Resources; Rodent; Sampling; Services; Standardization; Structure; Techniques; Technology; Tendon structure; Testing; Tissues; Training; Universities; Validation; base; bone; cost; design; genetic manipulation; genetic technology; improved; in vivo; insight; investigator training; neuromuscular function; new technology; operation; pre-clinical therapy; research study; technology development; therapy development; wasting

Michigan Integrative Musculoskeletal Health Core Center – Core D Project Summary Functional assessment of musculoskeletal phenotypes in animal models is critical to identifying mechanisms of how diseases affect the integrative health and function of patients suffering from various musculoskeletal conditions. The ability to study musculoskeletal phenotypes across a wide-ranging scale requires considerable expertise and highly specialized training in physiology, biophysics, and engineering, as well as access to costly, high-resolution, state-of-the-art equipment. While occasionally the expertise and equipment for single approaches can be developed in a single laboratory, developing these approaches can be cost prohibitive, redundant, and can lead to proliferation of non-uniform techniques across the field. The Functional Assessment Core (Core D) will bring together the animal, organ, tissue, and in some cases cellular level phenotyping capabilities currently used within individual laboratories at the University of Michigan into a cohesive and easily accessible core service that can be used by the entire musculoskeletal research community. Core D will integrate individual laboratory approaches to musculoskeletal biology and engineering by including state-of-the-art measurements in bone mechanics, muscle function and mechanics, and tendon mechanics. This will be implemented through prioritization of experiments for hypothesis-based testing, coordination of cross-core experiments, execution of high precision phenotyping studies, and collaboration among investigators within and external to the institution. Core D will also focus on expanding its offerings to both enhance the capabilities of the current Research Community and to further expand the breadth and depth of the Core Center. Four Aims are proposed: the Core will provide expertise and guidance on the design of experiments in Aim 1, and access in Aim 2 to state-of-the-art technologies and experts to allow quantification of animal, organ, and tissue function and to provide training in these methodologies. Further, in Aim 3, the Core will provide guidance with interpretation of results and make recommendations for future studies. Lastly, the overall goal of Aim 4 is to enable the research community through ongoing technology development and education. By providing the framework for testing samples, training investigators, and sharing resources, the Core will accomplish its goals of high level support for musculoskeletal phenotyping and the sharing of standard operating procedures among the greater musculoskeletal research community.

密歇根综合肌肉骨骼健康核心中心-核心D 项目摘要 在动物模型中对肌肉骨骼表型进行功能评估对于识别 疾病如何影响患者的综合健康和功能的机制 各种肌肉骨骼疾病研究肌肉骨骼表型的能力， 大范围的规模需要相当多的专业知识和高度专业的生理学培训， 生物物理学和工程学，以及获得昂贵的，高分辨率的，最先进的 设备.虽然偶尔可以使用单一方法的专业知识和设备， 在单个实验室中开发，开发这些方法可能成本过高， 这是多余的，并可能导致整个领域的非统一技术的扩散。的 功能评估核心（核心D）将汇集动物、器官、组织， 在某些情况下，细胞水平的表型分析能力目前在各个实验室中使用， 将密歇根大学整合为一个有凝聚力且易于访问的核心服务， 被整个肌肉骨骼研究界所认可核心D将整合各个实验室 包括最先进的肌肉骨骼生物学和工程方法 骨力学、肌肉功能和力学以及肌腱力学的测量。 这将通过对基于假设的测试的实验进行优先排序来实现， 协调跨核心实验，执行高精度表型研究，以及 研究机构内外的研究人员之间的合作。核心D也将重点 扩大其产品，以提高目前的研究社区的能力， 进一步拓展核心中心的广度和深度。提出了四个目标： 核心将提供专业知识和指导的目标1的实验设计，并访问 目标2：利用最先进的技术和专家，对动物、器官和 组织功能，并提供这些方法的培训。在目标3中，核心将 为结果解释提供指导，并为未来的研究提出建议。 最后，目标4的总体目标是使研究界能够通过持续的 技术发展和教育。通过提供测试样本的框架， 培训研究人员，共享资源，核心将实现其高水平的目标， 支持肌肉骨骼表型分析和共享标准操作程序 在肌肉骨骼研究界的影响。