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Role of Distortion Energy in Fibroblast-Mediated Remodeling of Collagen Matrices

畸变能在成纤维细胞介导的胶原基质重塑中的作用

基本信息

批准号：
10452423
负责人：
Trevor Justin Lujan
金额：
$ 11.35万
依托单位：
BOISE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-23 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10452423
关键词：
3-Dimensional Adopted Adoption Algorithms Anisotropy Awareness Behavior Biological Biomechanics Cells Chemicals Collagen Communities Computer software Confocal Microscopy Congresses Cytoskeleton Dense Connective Tissue Dependence Devices Documentation Educational workshop Engineering Ensure Extracellular Matrix Fiber Fibroblasts Fluorescence Microscopy Future Growth Image Intuition Laboratories Laboratory Research Length Liver Manuals Mathematics Measurement Measures Mechanics Mediating Molecular Muscle Notification Operating System Optics Parents Periodicity Property Publications Pythons Research Research Project Grants Role Running Science Software Engineering Software Tools Structure Structure-Activity Relationship Students System Testing Textiles Tissues Universities Validation base biological systems cloud based design engineering design image processing imaging modality improved light microscopy materials science mechanical behavior microscopic imaging muscle engineering preference repaired scaffold soft tissue software development spatiotemporal symposium tool tumor two-dimensional

项目摘要

PROJECT SUMMARY Dense connective tissue is composed of an abundant collagen network that is maintained and repaired by fibroblasts. The parent R15 proposal is investigating whether fibroblast-mediated collagen remodeling is governed at the tissue-scale by distortion strain energy. The effect of targeted magnitudes of distortion energy on collagen remodeling will be measured by quantifying alterations in the composition, organization, and mechanical behavior of the scaffolds. In order to quantify changes in fiber organization from confocal microscopy images, a software application called FiberFit is being used to automate the objective measurement of two structural properties that describe material anisotropy: fiber orientation and fiber dispersion. The standalone software application, FiberFit, was developed in the Northwest Tissue Mechanics laboratory in 2016 and is freely available to the scientific community for Windows and Mac systems. FiberFit has now been used in many research projects outside the developing laboratory, including research on tumors, liver, muscle, and engineered composite materials. This project will re-engineer FiberFit and deploy it as a cloud-based application. Emphasis will be placed on creating a robust, intuitive, and sustainable software application that implements best practices in software engineering and design to facilitate broad adoption across the scientific community.

项目摘要致密结缔组织由丰富的胶原蛋白网络组成，胶原蛋白网络通过以下方式维持和修复：成纤维细胞父R15提案正在研究成纤维细胞介导的胶原重塑是否是在组织尺度上由变形应变能控制。目标扭曲能量大小的影响将通过量化胶原蛋白的组成、组织和支架的机械性能。为了量化从共聚焦显微镜观察到的纤维组织的变化，显微镜图像，一个名为FiberFit的软件应用程序被用来自动化客观测量描述材料各向异性的两种结构性质：纤维取向和纤维分散。的独立软件应用程序FiberFit于2016年在西北组织力学实验室开发并免费提供给科学界的Windows和Mac系统。FiberFit现已被用于在许多研究项目以外的发展实验室，包括研究肿瘤，肝脏，肌肉，工程复合材料该项目将重新设计FiberFit并将其部署为基于云的应用程序.重点将放在创建一个强大的，直观的，可持续的软件应用程序，实施软件工程和设计方面的最佳实践，以促进科学领域的广泛采用。社区