癌症中心支持补助金-猫眼课题宝

癌症中心支持补助金

批准号：

10455154

负责人：

H. Shelton Earp

金额：

$24.99万

依托单位：

UNIV OF NORTH CAROLINA CHAPEL HILL

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

未结题

起止时间：

1997-06-01 至 2025-11-30

来源：

https://reporter.nih.gov/project-details/10455154

关键词：

Appointment Arts Award Basic Cancer Research Basic Science Behavioral Bioinformatics Biology Budgets Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Caregivers Caring Catchment Area Chemicals Clinic Clinical Data Clinical Protocols Clinical Research Clinical Sciences Clinical Trials Communication Communities Community Outreach Comprehensive Cancer Center Consultations Data Development Direct Costs Discipline of Nursing Disease Early Diagnosis Education and Outreach Epidemiology Epigenetic Process Evaluation Research Facility Construction Faculty Fostering Funding Future Gap Junctions Genetic Research Genomic approach Government Grant Health Health Resources Health Services Healthcare Human Incidence Information Systems Infrastructure Insurance Carriers Intervention Intervention Trial Investments Leadership Malignant Neoplasms Measures Medicaid Medicare Minority Groups Mission Molecular Epidemiology Monitor Morbidity - disease rate Names North Carolina Oncology Outcome Patient Care Patients Performance Pharmacologic Substance Pharmacy facility Policies Population Population Heterogeneity Population Sciences Prevention Privatization Productivity Protocols documentation Public Health Publications Publishing Research Research Personnel Resource Sharing Resources Role Rural Population Schools Science Scientist Services Stretching System Talents Technology The Cancer Genome Atlas Therapeutic Time Training Training and Education Translating Translations United States Universities Urban Population anticancer research authority base cancer care cancer genetics cancer health disparity cancer research center director cancer therapy career college community based participatory research community college community engagement data management drug discovery epidemiology study imaging detection innovation malignant breast neoplasm medical schools member minority disparity mortality multidisciplinary neoplasm registry operation population based population health programs public policy on tobacco recruit safety net screening services senior faculty survivorship undergraduate student

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英文摘要

Kaposi’s sarcoma (KS) is a human malignancy associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). KS continue to be the most common HIV-associated cancer world-wide. KS lesions are characterized by proliferating endothelial-derived spindle cells, leaky blood vessels, and inflammatory infiltrating leukocytes. Within these lesions, inflammatory leukocytes secret cytokines and growth factors that KSHV-infected cells rely on for growth and survival. KSHVinfected endothelial cells promote the infiltration of inflammatory cells by modulating the expression of adhesion factors on its surface. We have found that KSHV infection induces the expression of novel endothelial adhesion factors and increases leukocyte adhesion and transendothelial migration. We propose to determine the mechanism by which KSHV induces leukocyte adhesion and transendothelial migration and validate the biology of this process using tissue specimens from the AIDS and Cancer Specimen Resource (ACSR). Our proposal will also identify new targets for therapies against KS in HIV-infection individuals.

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