Targeted closed-loop intracranial brain-stimulation to improve episodic memory
有针对性的闭环颅内脑刺激可改善情景记忆
基本信息
- 批准号:10641003
- 负责人:
- 金额:$ 59.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAlgorithmsAlzheimer&aposs DiseaseAnatomyAnimalsAreaBehaviorBehavioralBiological MarkersBrainBrain DiseasesBrain regionCuesDevelopmentDiseaseEffectivenessElectric StimulationElectrodesElectrophysiology (science)Episodic memoryExhibitsFollow-Up StudiesHippocampusHumanImpaired cognitionImpairmentJointsKnowledgeLateralLeftLocationMedialMemoryMemory DisordersMemory impairmentModelingModernizationMultivariate AnalysisNeurodegenerative DisordersOutputPathologicPatientsPerformancePersonsPhasePhysiologicalPhysiologyPopulationPrefrontal CortexProcessPropertyReal-Time SystemsRetrievalRiskRoleSiteSocietiesStatistical ModelsStrokeSystemTemporal LobeTestingTimeTissuesTrainingTraining ActivityTraumatic Brain InjuryWorkdesignefficacy evaluationexperiencefunctional restorationimprovedinfancymemory encodingmemory retrievalnervous system disorderneuralneural correlateneural modelneural networkneural patterningneurosurgeryprogramsrepairedtheories
项目摘要
Project Summary
This project aims to determine how invasive closed-loop electrical stimulation can potentially rescue patterns of neural activity in the brain that give rise to successful memory
functions. With an eye towards helping people affected by disorders of memory – including the ever-growing population suffering from neurodegenerative diseases, such as
Alzheimer's – we propose to assess how functional brain dynamics can be used to guide
the optimal timing, location, and properties of direct brain stimulation. Prior work has
identified specific patterns of neural activity across the brain, principally spectral modulations in the theta (3-8 Hz) and gamma (30+ Hz) bands, that predict successful memory
encoding and retrieval. We recently observed that the effect of stimulation on memory
encoding depends on these neural signatures at the time it is delivered. Furthermore,
we have shown that the functional and structural connectivity profile of a stimulation
site relates to the effectiveness of stimulation on memory. Here, we aim to elucidate (1)
whether state-dependent stimulation can separately be used to modulate encoding and
retrieval processes, or whether common stimulation algorithms applied to both phases
can more optimally restore function, (2) whether stimulation is more effective when targeted to regions with specific connectivity profiles to the medial temporal lobe, and (3)
how simultaneous stimulation at multiple target sites can be optimized with knowledge
of the connectivities of those sites. More broadly, this project seeks to determine whether
biomarker-guided, closed-loop brain stimulation can be used to correct pathologic brain
states and restore the function of an impaired memory system.
项目摘要
该项目旨在确定侵入性闭环电刺激如何潜在地拯救大脑中导致成功记忆的神经活动模式
功能协调发展的着眼于帮助受记忆障碍影响的人-包括不断增长的患有神经退行性疾病的人口,如
阿尔茨海默氏症-我们建议评估功能性大脑动力学如何用于指导
直接脑刺激的最佳时机、位置和特性。以前的工作有
确定了大脑中神经活动的特定模式,主要是θ(3-8 Hz)和γ(30+ Hz)波段的频谱调制,这些模式预测了成功的记忆
编码和检索。我们最近观察到刺激对记忆的影响
编码取决于这些神经信号在它被传递的时候。此外,委员会认为,
我们已经表明,刺激的功能和结构连接性概况
部位与刺激对记忆的有效性有关。在这里,我们的目的是阐明(1)
状态依赖性刺激是否可以单独用于调制编码,
检索过程,或者是否将共同刺激算法应用于两个阶段
可以更优化地恢复功能,(2)当靶向具有到内侧颞叶的特定连接轮廓的区域时,刺激是否更有效,以及(3)
如何利用知识优化多个目标部位的同时刺激
这些地点的连通性。更广泛地说,该项目旨在确定是否
生物标志物引导的闭环脑刺激可用于纠正病理性脑
状态和恢复受损的记忆系统的功能。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Multiple-brain systems dynamically interact during tonic and phasic states to support language integrity in temporal lobe epilepsy.
- DOI:10.1016/j.nicl.2021.102861
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Modi S;He X;Chaudhary K;Hinds W;Crow A;Beloor-Suresh A;Sperling MR;Tracy JI
- 通讯作者:Tracy JI
Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
- DOI:10.1093/cercor/bhad427
- 发表时间:2024-01-14
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Hippocampal ripples signal contextually mediated episodic recall.
- DOI:10.1073/pnas.2201657119
- 发表时间:2022-10-04
- 期刊:
- 影响因子:11.1
- 作者:Sakon, John J.;Kahana, Michael J.
- 通讯作者:Kahana, Michael J.
Direct brain recordings suggest a causal subsequent-memory effect.
直接大脑记录表明存在因果后续记忆效应。
- DOI:10.1093/cercor/bhad008
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Rubinstein,DanielY;Weidemann,ChristophT;Sperling,MichaelR;Kahana,MichaelJ
- 通讯作者:Kahana,MichaelJ
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Michael Jacob Kahana的其他文献
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{{ truncateString('Michael Jacob Kahana', 18)}}的其他基金
Targeted closed-loop intracranial brain-stimulation to improve episodic memory
有针对性的闭环颅内脑刺激可改善情景记忆
- 批准号:
10199066 - 财政年份:2019
- 资助金额:
$ 59.69万 - 项目类别:
Using Direct Brain Stimulation to Study Cognitive Electrophysiology
使用直接大脑刺激研究认知电生理学
- 批准号:
10016846 - 财政年份:2019
- 资助金额:
$ 59.69万 - 项目类别:
Using Direct Brain Stimulation to Study Cognitive Electrophysiology
使用直接大脑刺激研究认知电生理学
- 批准号:
10241427 - 财政年份:2019
- 资助金额:
$ 59.69万 - 项目类别:
Targeted closed-loop intracranial brain-stimulation to improve episodic memory
有针对性的闭环颅内脑刺激可改善情景记忆
- 批准号:
10440284 - 财政年份:2019
- 资助金额:
$ 59.69万 - 项目类别:
Using Direct Brain Stimulation to Study Cognitive Electrophysiology
使用直接大脑刺激研究认知电生理学
- 批准号:
10654753 - 财政年份:2019
- 资助金额:
$ 59.69万 - 项目类别:
A Model-Based Approach to Understanding Memory Impairments in Normal Aging
基于模型的方法来了解正常衰老过程中的记忆损伤
- 批准号:
9127066 - 财政年份:2015
- 资助金额:
$ 59.69万 - 项目类别:
Intracranial EEG for Neuronal Oscillatory Contingency during Cognitive Tasks
认知任务期间神经元振荡意外事件的颅内脑电图
- 批准号:
7943074 - 财政年份:2009
- 资助金额:
$ 59.69万 - 项目类别:
Integrated Interdisciplinary Training in Computational Neuroscience.
计算神经科学综合跨学科培训。
- 批准号:
7906059 - 财政年份:2006
- 资助金额:
$ 59.69万 - 项目类别:
Integrated Interdisciplinary Training in Computational Neuroscience
计算神经科学综合跨学科培训
- 批准号:
7496641 - 财政年份:2006
- 资助金额:
$ 59.69万 - 项目类别:
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