Using Direct Brain Stimulation to Study Cognitive Electrophysiology

项目摘要 我们的项目旨在形成一个多地点联合体，将进行基本的实验- 阐明人类潜在的介观和微观神经动力学的新方法 并将直接脑刺激作为一种操作工具来研究这些动力学。 此外，我们试图创建一个动态时间序列模型来预测演化 在认知任务中的大脑活动，并结合了刺激诱导的效果 对系统的扰动。我们将从250pa收集记录和刺激数据- 志愿者在执行精心匹配的语言和空间记忆任务时被选中。杜尔- 在非刺激阶段，我们将测量记忆的相关神经生物标记物 使用标准临床深度电极和微线记录进行编码和检索。 为了测试这些生物标志物的因果作用，我们将采用直接脑刺激来 扰乱或上调神经活动，并测量随后的行为表现变化- 曼斯。有了一套因果生物标记物和预测模型，我们将fiNally 问一问，模型驱动的刺激范例是否增强了我们可靠地调节 实时的神经活动和相应的行为。

Project Abstract Our project aims to form a multi-site consortium that will carry out fundamental exper- iments to elucidate the mesoscopic and microscopic neural dynamics underlying human memory and use direct brain stimulation as a manipulative tool to study those dynamics. Additionally, we seek to create a dynamical timeseries model that predicts the evolution of brain activity during cognitive tasks and incorporates the e ects of stimulation-induced perturbations on the system. We will collect recording and stimulation data from 250 pa- tient volunteers as they perform carefully-matched verbal and spatial memory tasks. Dur- ing non-stimulation sessions, we will measure correlative neural biomarkers of memory encoding and retrieval using standard clinical depth electrodes and microwire recordings. To test the causal role of these biomarkers, we will employ direct brain stimulation to disrupt or upregulate neural activity, and measure ensuing changes in behavioral perfor- mance. With a set of causal biomarkers and predictive models in hand, we will finally ask whether model-driven stimulation paradigms o er us the ability to reliably modulate neural activity, and consequent behavior, in real-time.