Using Direct Brain Stimulation to Study Cognitive Electrophysiology

使用直接大脑刺激研究认知电生理学

• 批准号: 10016846
• 负责人: Michael Jacob Kahana
• 金额: $ 134.16万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016846
• 关键词: Behavior; Behavioral; Biological Markers; Brain; Brain region; Cells; Clinical; Cognition; Cognitive; Cognitive Therapy; Collaborations; Complex; Coupled; Data; Data Set; Dependence; Disease; Electric Stimulation; Electrical Stimulation of the Brain; Electrodes; Electroencephalography; Electrophysiology (science); Ensure; Episodic memory; Estrogen receptor positive; Evolution; Family; Funding; Future; Hand; Human; Implant; Link; Location; Measures; Memory; Microelectrodes; Microscopic; Modeling; Neurons; Patients; Pattern; Performance; Physiology; Process; Role; Site; Source; Structure; Suggestion; System; Testing; Therapeutic Intervention; Time; Tonic-Clonic Epilepsy; Work; base; cognitive task; cognitive testing; experience; experimental study; human model; improved; indexing; insight; memory encoding; memory retrieval; neurophysiology; predictive modeling; programs; recruit; relating to nervous system; spatial memory; tool; volunteer

Project Abstract Our project aims to form a multi-site consortium that will carry out fundamental exper- iments to elucidate the mesoscopic and microscopic neural dynamics underlying human memory and use direct brain stimulation as a manipulative tool to study those dynamics. Additionally, we seek to create a dynamical timeseries model that predicts the evolution of brain activity during cognitive tasks and incorporates the e ects of stimulation-induced perturbations on the system. We will collect recording and stimulation data from 250 pa- tient volunteers as they perform carefully-matched verbal and spatial memory tasks. Dur- ing non-stimulation sessions, we will measure correlative neural biomarkers of memory encoding and retrieval using standard clinical depth electrodes and microwire recordings. To test the causal role of these biomarkers, we will employ direct brain stimulation to disrupt or upregulate neural activity, and measure ensuing changes in behavioral perfor- mance. With a set of causal biomarkers and predictive models in hand, we will finally ask whether model-driven stimulation paradigms o er us the ability to reliably modulate neural activity, and consequent behavior, in real-time.

项目摘要 我们的项目旨在形成一个多地点的联盟，将进行基本的实验， 目的是阐明人类潜在的中观和微观神经动力学 并使用直接脑刺激作为研究这些动力学的操纵工具。 此外，我们试图创建一个动态时间序列模型，预测的演变 在认知任务中的大脑活动，并结合了刺激诱导的效应， 系统的扰动。我们将收集250 Pa的记录和刺激数据- 当他们完成仔细匹配的语言和空间记忆任务时，Dur- 在非刺激阶段，我们将测量记忆的相关神经生物标志物， 使用标准临床深度电极和微丝记录进行编码和检索。 为了测试这些生物标志物的因果作用，我们将采用直接脑刺激， 扰乱或上调神经活动，并测量随后的行为表现变化， 曼斯有了一套因果生物标志物和预测模型，我们最终将 问模型驱动的刺激范式是否超过了我们可靠调节 神经活动和随之而来的行为。